CD8+ CD56+ Mycosis Fungoides with an Indolent Clinical Behaviour: Case Report and Literature Review

Sawada, Yu; Sugita, Kazunari; Kabashima, Rieko; Hino, Ryosuke; Nakamura, Motonobu; Koga, Chizuko; Tokura, Y.

doi:10.2340/00015555-0831

Cited by 19 publications

(29 citation statements)

References 6 publications

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“…Another CD8 + MF variant with the clinical presentation of poikilodermatous plaques has been reported. [33] All patients with poikilodermatous plaques in our study showed the common immunophenotype of CD4 + and CD8 − .…”

Section: Discussionmentioning

confidence: 70%

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

et al. 2016

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Background:Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India.Aim:To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patientsMaterials and Methods:This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. The patients underwent clinical examination, human T-cell lymphotropic virus-1 (HTLV-1) screening, skin biopsy with hematoxylin and eosin and immunohistochemistry staining.Results:Among 35 cases, 33 (94.3%) were T-cell, and 2 (5.7%) were B-cell lymphomas. The mean age was 52.66, and the male to female ratio was 2.5:1. The most common types of T-cell lymphomas included mycosis fungoides (MF) (57.1%) followed by adult T-cell lymphoma/leukemia (ATL) (17.1%). Primary cutaneous peripheral T-cell lymphoma not otherwise specified was diagnosed in 17.1% and anaplastic large cell lymphoma in 2.9%. The morphological types of MF included polymorphic, poikilodermatous, folliculotropic, hypopigmented, hyperpigmented, mixed, and purpuric. Skin manifestations of ATL included ulcerated plaques and erythroderma. Epidermotropism was very marked in ATL (83.3%) than in MF (70%). Larger Pautrier's microabscess was noted in ATL compared to smaller ones in MF. Markedly dense, diffuse infiltrate of atypical cells was noted in ATL in contrast to mild to moderate nodular or perivascular infiltrate in MF. ATL had an extremely poor prognosis.Limitations:Identification of DNA integration of HTLV-1 by Southern blot could not be analyzed, and the number of cases studied is limited.Conclusions:The study showed unique patterns of subtypes of cutaneous lymphomas in our country. Variations in the clinical pattern and histopathological analysis will help to differentiate T-cell lymphoma types which have prognostic implications.

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Section: Discussionmentioning

confidence: 70%

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

et al. 2016

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“…17 Expression of CD56 has been documented only in sporadic case reports. [18][19][20][21][22][23][24][25] Interestingly, also on the molecular level, variability in TCRg gene rearrangement has been described in concurrent biopsies of MF from the same patient. 26 Our findings suggest that in a single patient, there may be substantial phenotypic variation between lesions of MF present at the same time.…”

Section: Discussionmentioning

confidence: 93%

Phenotypic Variation in Different Lesions of Mycosis Fungoides Biopsied Within a Short Period of Time From the Same Patient

Kash

Massone

Fink‐Puches

et al. 2016

The American Journal of Dermatopathology

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Phenotypic variants of mycosis fungoides (MF) include mainly the expression of cytotoxic markers by neoplastic cells (either α/β or γ/δ cytotoxic). To manage the patient properly, distinction from other cutaneous cytotoxic natural killer/T-cell lymphomas is paramount. Particularly for cutaneous γ/δ T-cell lymphoma, distinction is often based on clinicopathologic correlation (presence of tumors at first diagnosis as opposed to patches only in MF). The authors report a case of cytotoxic MF characterized by expression of TCRγ in two of three biopsies performed within a time frame of 1 week. The patient presented with patches, plaques, and 1 tumor at the time of first diagnosis; thus, distinction from cutaneous γ/δ T-cell lymphoma was not possible on clinical grounds alone. The diagnosis of MF was established, thanks to the phenotypic variations revealed by the three biopsies, with 1 lacking expression of cytotoxic proteins (TIA-1 and granzyme B) and of TCRγ. This case shows the importance to perform several biopsies in cases of cutaneous lymphoma, as morphologic and phenotypic features are variable and information gathered from a single biopsy may result in a wrong diagnosis.

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“…Several reports of MF with CD8+ and/or CD56+ expression have suggested that this variant would have no prognostic difference compared with classic MF[2,3,5,7-10]. Massone et al .…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Variant of Mycosis Fungoides with CD8+ CD56+ Phenotype: A Case Report and Review of Literature

et al. 2014

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CD8+ CD56+ Mycosis Fungoides with an Indolent Clinical Behaviour: Case Report and Literature Review

Cited by 19 publications

References 6 publications

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

Phenotypic Variation in Different Lesions of Mycosis Fungoides Biopsied Within a Short Period of Time From the Same Patient

Cytotoxic Variant of Mycosis Fungoides with CD8+ CD56+ Phenotype: A Case Report and Review of Literature

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