CDw108 expression during T‐cell development

Mizutani, Takashi; Harada, Kenji; Matsumoto, Tomoko; Yamana, Hideaki; Shirouzu, K.; Itoh, Kyogo; Yamada, Akira

doi:10.1034/j.1399-0039.2000.550505.x

Cited by 43 publications

(29 citation statements)

References 23 publications

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“…Indeed, the addition of Sema7A influenced monocyte chemotaxis 1000 times more efficiently than did MCP-1, and it influenced neutrophil chemotaxis 100 times better than did IL-8 stimulation (25). Sema7A is abundantly expressed in monocytes, neutrophils, and other lymphoid cells (25,28,29). A recent study showed a biphasic response of PMNs to WNV infection; they serve as a reservoir for WNV replication and dissemination in the early stages of infection and later contribute to WNV clearance (42).…”

Section: Discussionmentioning

confidence: 99%

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Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling

Sultana

Neelakanta

Foellmer

et al. 2012

The Journal of Immunology

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Semaphorin 7A (Sema7A) is a membrane-associated/secreted protein that plays an essential role in connecting the vertebrate neuronal and immune systems. However, the role of Sema7A has not been elucidated in viral pathogenesis. In this study, we show that abrogation of Sema7A protects mice from lethal West Nile virus (WNV) infection. Mice lacking Sema7A showed increased survival, reduced viral burden, and less blood–brain barrier permeability upon WNV infection. Increased Sema7A levels were evident in murine tissues, as well as in murine cortical neurons and primary human macrophages upon WNV infection. Treatment with Sema7A Ab blocked WNV infection in both of these cell types. Furthermore, Sema7A positively regulates the production of TGF-β1 and Smad6 to facilitate WNV pathogenesis in mice. Collectively, these data elucidate the role of Sema7A in shared signaling pathways used by the immune and nervous systems during viral pathogenesis that may lead to the development of Sema7A-blocking therapies for WNV and possibly other flaviviral infections.

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Section: Discussionmentioning

confidence: 99%

“…Sema7A is expressed broadly by lymphoid cells, myeloid cells, bone cells, the nervous system, epidermal keratinocytes, fibroblasts, and endothelial cells of blood vessels (25,28,29). In addition, human T lymphocytes and NK cells express Sema7A at high levels (30).…”

mentioning

confidence: 99%

Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling

Sultana

Neelakanta

Foellmer

et al. 2012

The Journal of Immunology

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“…Sema7A is expressed in activated lymphocytes and thymocytes, and also in monocytes for which it could act as an autocrine activator [68,69]. T cells from Sema7A -/-mice are hyper responsive in vitro, suggesting that Sema7A is a negative regulator of T cell responses [70].…”

Section: Review Articlementioning

confidence: 99%

The many faces of semaphorins: from development to pathology

Roth

Koncina

Šatkauskas

et al. 2008

Cell. Mol. Life Sci.

163

144

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The semaphorin family is a large group of proteins controlling cell migration and axonal growth cone guidance. These proteins are bi-functional signals capable of growth promotion or growth inhibition. Initially described in the nervous system, the majority of studies related to semaphorins and semaphorin signalling are nowadays performed in model systems outside the nervous system. Here, we provide an exhaustive review of the many faces of semaphorins both during developmental, regulatory and pathological processes. Indeed, because of their crucial fundamental roles, the semaphorins and their receptors represent important targets for the development of drugs directed at a variety of diseases.

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“…The vector encoding mouse Sema7A (Sema7A-pCMV-SPORT) was kindly provided by A. Yamada (Mine et al, 2000). Sema7A cDNA was subcloned into the EcoRI/HindIII site of pBluescript SK (ϩ/Ϫ).…”

Section: Methodsmentioning

confidence: 99%

Caspase-9 Activation Revealed by Semaphorin 7A Cleavage Is Independent of Apoptosis in the Aged Olfactory Bulb

Ohsawa¹,

Hamada²,

Asou³

et al. 2009

J. Neurosci.

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Caspases are essential in multicellular organisms for inducing cell death during normal development and in the immune system. However, caspases can also trigger the degenerative process under certain conditions such as pathophysiological conditions and aging. Here, we identified Semaphorin 7A (Sema7A) as a novel substrate for caspase-9 that can be used to monitor caspase-9 activity in mice, and found nonapoptotic caspase-9 activation in the aged olfactory bulb (OB). Immunostaining of the OB for the caspase-9-cleaved form of Sema7A revealed abundant caspase-9-activated cells in 2-year-old (aged) but not in 2-month-old (young) mice. In fact, various regions of the aged brain, including the OB, exhibited an increased level of caspase-9 activity. However, the number of dying cells in the aged OB was, intriguingly, much lower (Ͻ20%) than in the OB of young mice. Furthermore, we found that the lower number dying cells in the aged OB was accompanied by a decreased expression of procaspase-3. These results suggest a survival strategy for aged OB neurons, which can no longer regenerate, in which the central apoptotic machinery downstream of caspase-9 is inactivated.

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CDw108 expression during T‐cell development

Cited by 43 publications

References 23 publications

Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling

Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling

The many faces of semaphorins: from development to pathology

Caspase-9 Activation Revealed by Semaphorin 7A Cleavage Is Independent of Apoptosis in the Aged Olfactory Bulb

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