Ce-MOF/COF/carbon nanotube hybrid composite: Construction of efficient electrochemical immune platform for amplifying detection performance of CA125

An, Yaqi; Dong, Shaojun; Chen, Hao; Guan, Li

doi:10.1016/j.bioelechem.2022.108201

Cited by 12 publications

(2 citation statements)

References 41 publications

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“…The prepared biosensors were in close agreement with the results of the chemiluminescence immunoassay commonly used in hospitals. Dong et al 68 designed and synthesized MOF, COF, and CNT hybrid materials for the construction of label-free CA125 immunosensors. TPN-COF/CNT was prepared using a mixture of terephthalonitrile (TPN), ZnCl 2 , and CNTs by a milling and calcination process.…”

Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in immunology. However, the active centers of protein biomarkers are surrounded by a peptide matrix, which hinders charge transfer and results in insufficient sensor sensitivity. Therefore, electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein sensors. In this review, we summarize recent reports of electrochemical biosensors for protein biomarker detection. We highlight the latest research on electrochemical protein biosensors for the detection of cancer, viral infectious diseases, inflammation, and other diseases. The corresponding sensitive materials, transducer structures, and detection principles associated with such biosensors are also addressed generally. Finally, we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

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Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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“…[ 8 ] Dong's group developed Ce‐MOF/TPN‐COF/CNT hybrid material to construct a label‐free immunosensor for specific detection of carcinomicantigen 125. [ 9 ] It is undeniable that the development of multi‐component MOF@COF composites stands as one of the most effective approaches to broadening the diversity and characteristics of reticular materials. Remarkably, such characteristics have been scarcely explored in OPECT biosensing research.…”

Section: Introductionmentioning

confidence: 99%

Reticular Heterojunction for Organic Photoelectrochemical Transistor Detection of Neuron‐Specific Enolase

Hou,

Gao,

Kong

et al. 2024

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Reticular heterojunctions on the basis of metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) have sparked considerable interest in recent research endeavors, which nevertheless have seldom been studied in optoelectronic biosensing. In this work, its utilization for organic photoelectrochemical transistor (OPECT) detection of the important cancer biomarker of neuron‐specific enolase (NSE) is reported. A MOF@COF@CdS quantum dots (QDs) heterojunction is rationally designed to serve as the photogating module against the polymeric channel. Linking with a sandwich complexing event, target‐dependent alternation of the photogate is achieved, leading to the changed photoelectric conversion efficiency as indicated by the amplified OPECT signals. The proposed assay demonstrates good analytical performance in detecting NSE, featuring a linear detection range from 0.1 pg mL−1 to 100 ng mL−1, with a detection limit of 0.033 pg mL−1.

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Sandwich-type electrochemical immunosensing of CA125 by using nanoribbon-like Ti3C2Tx MXenes and toluidine blue/UIO-66-NH2

Mei,

Zeng,

et al. 2024

ANAL. SCI.

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Ce-MOF/COF/carbon nanotube hybrid composite: Construction of efficient electrochemical immune platform for amplifying detection performance of CA125

Cited by 12 publications

References 41 publications

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Reticular Heterojunction for Organic Photoelectrochemical Transistor Detection of Neuron‐Specific Enolase

Sandwich-type electrochemical immunosensing of CA125 by using nanoribbon-like Ti3C2Tx MXenes and toluidine blue/UIO-66-NH2

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