Cefepime-induced encephalopathy in patient without renal failure

Coelho, Fernando Morgadinho Santos; Bernstein, Mauricio; Yokota, Paula Kiyomi Onaga; Coelho, Rosilene Motta Elias; Wachemberg, Marcelo; Sampaio, Letícia Pereira de Brito; Caboclo, Luís Otávio Sales Ferreira

doi:10.1590/s1679-45082010rc1121

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…Esta realidade da Mesorregião Centro-Ocidental do Rio Grande do Sul pode ser comprovada pelo fato de pouco mais de 5% dos animais remetidos para necropsia sejam da espécie suína e as principais doenças diagnosticadas reflitam o modo de criação. Para se determinar a causa da morte ou razão para eutanásia de um animal, independente da espécie, é imprescindível que o cadáver esteja em bom estado de conservação (Coelho 2002, Guillamón & Jalón 2010. A falta de conservação do material foi motivo de inconclusão em quase 11% dos casos revisados.…”

Section: Resultsunclassified

Características e frequência das doenças de suínos na Região Central do Rio Grande do Sul

et al. 2013

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RESUMO.-Visando-se determinar as características e frequência das doenças na população suína na região de abrangência do Laboratório de Patologia Veterinária (LPV) da Universidade Federal de Santa Maria (UFSM), foi realizado um estudo retrospectivo de todos os diagnósticos de necropsias realizadas nesta espécie no período de 1964 a 2011. Foram separados 564 casos com diagnósticos conclusivos. A criação suína na região de abrangência do estudo é predominantemente familiar e as doenças diagnosticadas, refletem esta realidade. As doenças infecciosas e parasitá-rias foram as mais prevalentes [380(68,1%) was carried out in order to determine the characteristics and frequency of diseases in the swine population raised in the region the region covered by the activities of LPV. Five hundred and four cases with conclusive diagnosis were found. The type of pig-raising in the area is mainly a familiar enterprise and the diseases found in this survey reflect this reality Infectious and parasitic diseases were the most prevalent [380(68.1%)], followed, in descending order of frequency, by nutritional and metabolic diseases [64(11.5%)], poisonings and toxi-infections and development disorders [15(2.7%)]. Other disorders due to varying etiologies, especially trauma, were cause of death in just over 11% of the cases. Bacterial diseases were responsible for more than half of the causes of death in pigs of the studied population, pointing to the influence of management, environmental and nutritional regional husbandry. The moist frequent disease diagnosed in pigs in the region in the region covered by the study was edema disease which along with other forms of infection by Escherichia coli was responsible for 23% of deaths. Viral diseases and neoplasm were not major causes of death in pigs in the region studied. Nutritional hepatosis and aflatoxicosis are important diseases in pigs in this region and and there causation are mainly linked to nutritional management.INDEX TERMS: Swine diseases, veterinary pathology, epidemiology, causes of death, retrospective study.

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Section: Resultsunclassified

Características e frequência das doenças de suínos na Região Central do Rio Grande do Sul

et al. 2013

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“…Previous reports showed that CPM neurotoxicity could appear in patients with renal impairment, and most cases have occurred in patients whose standard dosages were not adjusted for their renal function ( Garces et al, 2008 ; Fugate et al, 2013 ). However, some articles also reported that CPM induced neurotoxicity in patients with normal renal function ( Coelho et al, 2010 ; Meillier and Rahimian, 2016 ). The main mechanism of cephalosporin neurotoxicity involves a decrease of λ-aminobutyric acid (GABA) released from nerve terminals and a subsequent increase of excitatory neurotransmission.…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioral Effects of Cephalosporins: Assessment of Locomotors Activity, Motor and Sensory Development in Zebrafish

et al. 2018

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Most third- and fourth-generation cephalosporins, such as cefotaxime, cefmenoxime, cefepime, and cefpirome, contain an aminothiazoyl ring at the C-7 position. Drug impurity, which may be produced either during synthesis or upon degradation, can induce adverse effects. Various reports have indicated that neurotoxicity is a side effect of cephalosporin. In this study, we developed methods for assessing the free-swimming activities and behaviors in zebrafish larvae in response to continuous darkness and stimulation of light-to-dark photoperiod transition by chemical treatments. We also performed transcriptome analysis to identify differentially expressed genes (DEGs). Gene ontology analysis revealed that various processes related to nervous system development were significantly enriched by DEGs. We integrated 16 DEGs with protein–protein interaction networks and identified that neuroactive ligand–receptor interaction [e.g., λ-aminobutyric acid and glutamate receptor, metabotropic 1a (GRM1A)] pathway was regulated by the compounds. Our findings suggested that neurobehavioral effects mainly depend on the mother nucleus structure 7-aminocephalosporanic acid and the substitution at the C-3 position. In addition, gad2, or111-4, or126-3, grm1a, opn8c, or111-5, or113-2, and or118-3 may potentially be utilized as novel biomarkers for this class of cephalosporins, which causes neurotoxicity. This study provides neurological behavior, transcriptome, and docking information that could be used in further investigations of the structures and developmental neurotoxicity relationship of chemicals.

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“…In the present study, 11.11% of the cases presented a process of autolysis that made diagnosis impossible, a fact attributed to the time of arrival of the cadaver to the laboratory, which in free-living wild animals is longer, since most of these animals are found randomly in the environment hours after death, and the inadequate conditions of preservation of the body leads to rapid tissue destruction by the action of proteolytic enzymes produced during cadaveric decomposition. These alterations may mask the real lesions and induce mistaken interpretations, which makes diagnosis difficult or impossible (Coelho 2002). Thus, it is recommended to perform the necropsy soon after the death of the animal, so that all changes are preserved and the diagnosis of the cause of death is reached.…”

Section: Discussionmentioning

confidence: 99%

Anatomopathological findings of Testudines necropsied in the Distrito Federal, Brazil

et al. 2022

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In order to determine the main anatomopathological findings of Testudines necropsied in the Distrito Federal, all necropsy records performed at the “Laboratório de Patologia Veterinária” of the “Universidade de Brasília” (LPV-UnB) on Testudines during the period from January 2008 to July 2020 were reviewed. The 72 cases reviewed were grouped and classified according to species, sex, origin, season of occurrence, and diagnosis. In 69.44% of the cases the species was informed in the necropsy protocols, which included Phrynops geoffroanus (38%), Trachemys dorbigni (36%), Chelonoidis carbonaria (14%), Chelonoidis denticulata (10%) and Podocnemis expansa (2%). In 30.55% of the cases this parameter was not informed and were classified only as Testudines. In 41.66% of the cases the sex was informed, being female 22.22%, male 19.44%, and 58.33% were not informed. Of these animals 79.16% were from environmental agencies and 20.84% from zoos and/or guardians. In 70.83% of the animals analyzed they were directly related to the autumn and winter seasons, with June being the most frequent month (29.17%). The conclusive diagnosis was possible in 68.05% of the cases. The category of disorders caused by injurious agents (48.97%) was the most prevalent, followed by inflammatory disorders (32.65%) and nutritional and metabolic disorders (28.57%). The main diagnoses were carapace and/or plastron fracture with 30.61%, hepatic steatosis (20.40%) and pneumonia (10.22%). Most cases of carapace or plastron fracture and hepatic steatosis occurred in animals from environmental agencies.

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Cefepime-induced encephalopathy in patient without renal failure

Abstract: This case report describes neurotoxicity in an older patient on cefepime 2 g twice a day. The 81-year-old male patient developed non-convulsive status epilepticus during cefepime treatment with 1 g twice a day. There was recovery 30 days after discontinuation of cefepime.

Cited by 7 publications

References 14 publications

Características e frequência das doenças de suínos na Região Central do Rio Grande do Sul

Características e frequência das doenças de suínos na Região Central do Rio Grande do Sul

Neurobehavioral Effects of Cephalosporins: Assessment of Locomotors Activity, Motor and Sensory Development in Zebrafish

Anatomopathological findings of Testudines necropsied in the Distrito Federal, Brazil

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