Cefonicid Concentrations in Human Aqueous Humor

Axelrod, Judith L.; Kochman, Richard S.

doi:10.1001/archopht.1984.01040030347035

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…(13,14) In the rabbit, using similar techniques for injection and evaluation of toxicity, ceftriaxone injected into the vitreous in doses up to 5 mg did not alter the b-wave amplitude of the electroretinogram. Higher doses decreased the amplitude of the b-wave, but there was recovery after two weeks.…”

Section: Discussionmentioning

confidence: 41%

Retinal Toxicity of Intravitreal Cefoperazone

O’Hara¹,

Bode²,

Kincaid³

et al. 1986

Journal of Ocular Pharmacology and Therapeutics

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Cefoperazone is a broad spectrum, third-generation cephalosporin with potential usefulness in treating endophthalmitis because of its in vitro activity against Gram-negative organisms.Retinal toxicity was evaluated via serial indirect ophthalmoscopy, electrophysiologic testing and histopathologic examination of 43 Dutch-belted rabbit eyes injected intravitreally with 2, 4, 8, 16 or 32 mg of cefoperazone in a volume of 0.1 cc each. They were compared with seven eyes injected with sterile saline. Results show electroretinographic and histological evidence of retinal toxicity at concentrations of 16 mg or greater, while a single intravitreal dose of 8 mg or less of cefoperazone produced no evidence of retinal toxicity.

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Section: Discussionmentioning

confidence: 41%

Retinal Toxicity of Intravitreal Cefoperazone

O’Hara¹,

Bode²,

Kincaid³

et al. 1986

Journal of Ocular Pharmacology and Therapeutics

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Intravitreal penetration of oral pefloxacin in humans

Öncel

Peyman

1993

Int Ophthalmol

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We measured vitreous and serum levels of pefloxacin after oral administration. Twenty patients with retinal detachments undergoing vitrectomy were recruited into this study. Each patient received 400 mg pefloxacin orally 1 to 12 hours before vitrectomy. Vitreous fluid (0.1 mL) was aspirated at surgery. Vitreous levels of pefloxacin were determined by high-performance liquid chromatography. Six hours after oral administration, an average level of 1.37 microgram/mL of pefloxacin was measured in the vitreous samples. These levels were well above the minimum inhibitory concentration (MIC) for most organisms termed sensitive to pefloxacin. Oral administration of pefloxacin may play an important role in the prevention or management of endophthalmitis.

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