Cefsulodin: antibacterial activity and tentative interpretive zone standards for the disk susceptibility test

Barry, Arthur L.; Jones, Rn; Thornsberry, Clyde

doi:10.1128/aac.20.4.525

Cited by 16 publications

(4 citation statements)

References 8 publications

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“…Regression data for cefsulodin are simi lar to findings obtained by other workers [2]. Regression data for ceftriaxone and azthreonam have not previously been re ported but our data approximate unpub lished information from the respective manufacturers [Roy Cleland, Richard B. Sykes, personal commun.].…”

Section: Discussionsupporting

confidence: 71%

“…Previous studies [2,6,8,9] have confirmed that the nonfermenter sensitivity spectrum of cefsulodin and azthreonam is for practical purposes con fined to P. aeruginosa. Ceftazidime exhibi ted the broadest spectrum, [5,7,10,13,15,17], and was the only agent to be active against the majority of strains tested, in cluding P. mallophilia , P. fluorescens/P.…”

Section: Discussionmentioning

confidence: 95%

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Susceptibility of 324 Nonfermentative Gram-Negative Rods to 6 Cephalosporins and Azthreonam

Appelbaum¹,

Tamim²,

Pankuch³

et al. 1983

Chemotherapy

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Susceptibility of 324 isolates of nonfermentative gram-negative bacteria to cephalothin, cefamandole, cefoxitin, ceftriaxone, ceftazidime, cefsulodin, and azthreonam was determined by agar dilution and disc diffusion techniques. With the exception of Moraxella species, first- and second-generation cephalosporins were minimally active against nonfermenters tested. Cefsulodin and azthreonam were mainly active against Pseudomonas aeruginosa. In contrast, ceftazidime and ceftriaxone exhibited wider activity spectra. Cefsulodin and ceftazidime were the most active against P. aeruginosa, followed by azthreonam and ceftriaxone. Ceftazidime was the only drug with significant activity against Pseudomonas maltophilia and Pseudomonas fluorescens/ Pseudomonas putida, and was also the most active against Pseudomonas cepacia. Acine-tobacter calcoaceticus and Alcaligenes strains were most sensitive to ceftazidime, followed by ceftriaxone and azthreonam. Ceftriaxone was the most active against moraxellas, followed by cefamandole/cefoxitin, ceftazidime, cephalothin, cefsulodin, and azthreonam. Ceftazidime was the most active against uncommonly isolated nonfermenters. Results observed in this study reflect a potential use for ceftazidime in therapy of infections caused by most gram-negative nonfermenters; therapy with cefsulodin and azthreonam in nonfermenter infections should be restricted to those caused by P. aeruginosa, and that with ceftriaxone reserved for non-P. aeruginosa infections.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 95%

Susceptibility of 324 Nonfermentative Gram-Negative Rods to 6 Cephalosporins and Azthreonam

Appelbaum¹,

Tamim²,

Pankuch³

et al. 1983

Chemotherapy

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“…The same batch of MueUer-Hinton agar (BBL) was used throughout the study. Zone sizes were interpreted according to the NCCLS tables (2) except in the case of eefsulodin (8), ciprofloxacin (9), colistin (10) and ofloxacin (11 ), for which no NCCLS data exist for the time being. The quality control strains included daily were the same as in the Cobas-Bact test.…”

mentioning

confidence: 99%

Comparison of the Cobas-Bact five-hour susceptibility testing system with the NCCLS agar diffusion and dilution methods

Wüst

Heizmann

Hardegger

et al. 1988

Eur. J. Clin. Microbiol. Infect. Dis.

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The results of susceptibility tests performed by the Cobas-Bact system were compared with those of the NCCLS agar diffusion (Kirby-Bauer) and NCCLS agar dilution methods. A total of 998 clinical isolates were tested against 10 to 18 antimicrobial agents. Essential agreement (comprising full agreement and minor discrepancies) varied from 90.5% to 99.2% on comparison of Cobas-Bact with Kirby-Bauer results, depending on the bacterial group (mean for all 998 strains tested 95.7%). These figures ranged from 91% to 99.2% (mean 96.3%) for the Cobas-Bact/MIC comparison and from 95.2% to 99.7% (mean 98.7%) for the Kirby-Bauer/MIC comparison. The best results were found for Enterobacteriaceae and Staphylococcus aureus, whereas for enterococci and coagulase-negative staphylococci there was a lower rate of essential agreement in all three comparisons. In the case of Pseudomonas aeruginosa there was a good rate of essential agreement but many minor discrepancies, resulting in a disappointing rate of full agreement of between 67.5% and 78.9% in the three comparisons. The Cobas-Bact system would appear to provide satisfactory susceptibility test results in most cases, however there are still some major problems in the system which should be resolved.

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“…For each isolate, two MIC values and three zone diameters were generated by each laboratory. The test strains were derived from a collection of isolates utilized in a similar, recently reported study (2). Included were 77 P. aeruginosa, 5 P. maltophilia, 2 P. stutzeri, 2 P. cepacia, 1 P. acidovorans, 1…”

mentioning

confidence: 99%

Azlocillin, a ureido penicillin active against Pseudomonas aeruginosa: interpretive zone standards and quality control parameters for tests with 75-mu g disks

Barry¹,

Jones²,

Thornsberry³

et al. 1982

J Clin Microbiol

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A nine-laboratory coordinated study was performed to establish tentative control limits for 75-,ug azlocillin disks tested against the standard control strain of Pseudomonas aeruginosa (ATCC 27853). Control limits for individual tests were 24 to 30 mm (25 to 29 mm for means of five separate tests). To establish interpretive zone standards for 75-,ug azlocillin disks, three separate laboratories each tested 93 strains of P. aeruginosa or related species. Geometric mean minimal inhibitory concentrations (MICs) were plotted against arithmetic mean zone diameters. Regression analyses were performed with zone diameter as the independent variable and also with MIC as the independent variable. The following interpretive categories were recommended: resistant, <14 mm (MIC, >128 ,ug/ml); intermediate, 15 to 17 mm (MIC, 128,ug/ml); and susceptible, >18 mm (MIC, <64 jig/ml).

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Cefsulodin: antibacterial activity and tentative interpretive zone standards for the disk susceptibility test

Cited by 16 publications

References 8 publications

Susceptibility of 324 Nonfermentative Gram-Negative Rods to 6 Cephalosporins and Azthreonam

Susceptibility of 324 Nonfermentative Gram-Negative Rods to 6 Cephalosporins and Azthreonam

Comparison of the Cobas-Bact five-hour susceptibility testing system with the NCCLS agar diffusion and dilution methods

Azlocillin, a ureido penicillin active against Pseudomonas aeruginosa: interpretive zone standards and quality control parameters for tests with 75-mu g disks

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