Ceftizoxime Use In Trauma Celiotomy: Pharmacokinetics and Patient Outcomes

Abstract

Seriously injured patients undergo vigorous resuscitation upon arrival at the emergency department and through the immediate perioperative period. Although resuscitation leads to volume loading and fluid shifts, drug dosing and dosing intervals are often not altered to account for changes in total body volume or circulatory volume. To address this, a prospective study of pharmacokinetics of ceftizoxime in 53 injured adults who underwent emergency celiotomy was conducted. Further, the relationship between serum ceftizoxime concentrations and infectious outcomes was evaluated. Per protocol, injured adults undergoing emergency celiotomy received prophylactic ceftizoxime treatment according to standard dosing regimens. Of the patients, 6 (11.5%) experienced postoperative infections and had lower peak serum ceftizoxime levels in the recovery room than patients not experiencing infection. For severely injured adults with extensive blood loss or undergoing lengthy operations requiring rigorous volume resuscitation, doses of ceftizoxime, and indeed all antibiotics, may need to be increased beyond conventional standards to minimize infectious complications.

Intraoperative Positive Fluid Balance Improves Tissue Diffusion of Ceftizoxime

“…In fact, in a clinical trial on 53 patients undergoing emergency explorative laparotomy, Rosemurgy et al [31] found that signifi cant blood losses and subsequent abundant fl uid replacement caused serious reductions in antibiotic serum concentrations that are signifi cantly related to the appearance of postoperative infection.…”