Ceftriaxone-Induced Immune Hemolytic Anemia

Singh, Anil Kumar; Singhania, Namrata; Sharma, Amit; Sharma, Namita; Samal, Subhankar

doi:10.7759/cureus.8660

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Drugs reported in these cases include amoxicillin/clavulanate and piperacillin/tazobactam (first patient), azithromycin (second patient), lopinavir (third patient), oseltamivir, lopinavir/ritonavir, azithromycin, ceftriaxone and piperacillin/tazobactam (fourth patient) and piperacillin/tazobactam, azithromycin and ceftriaxone (fifth case). These drugs could potentially have contributed to the development of HA in these patients, as already reported in literature [ 22 – 25 ]. However, there are no reported cases in which the use of these drugs may have triggered HA in patients with G6PDD.…”

Section: Discussionmentioning

confidence: 62%

Glucose-6-phosphate dehydrogenase deficiency and hydroxychloroquine in the COVID-19 era: a mini review

et al. 2021

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The coronavirus disease 2019 (COVID-19) is until today a global health emergency. In an immense effort, effective drugs against COVID-19 are searched and intensive researches on possible repurposing of antiviral agents are performed. Since chloroquine (CQ) and hydroxychloroquine (HCQ) have shown in vitro anti- COVID-19 activities, the potential effect of CQ/HCQ to treat and/or prevent COVID-19 infection has caused global attention. However, concern regarding possible hemolysis in G6PD-deficient COVID-19 patients exists and for this reason, the association between HCQ and G6PD deficiency (G6PDD) is back in the limelight. This study aims to answer the question raised by Mastroianni et al. “Hydroxychloroquine: Culprit or Innocent Bystander in G6PD-Deficient Patients with COVID-19?” , reporting all cases of HCQ in G6PD deficient COVID-19 patients published on PubMed (pubmed.ncbi.nlm.nih.gov), in addition to the Mastroianni’s patient. In our opinion, after an accurate revision of these cases and responding the question raised by Mastroianni et al., we believe that it is difficult to reach a final verdict about the definitive role of HCQ in these patients. The COVID-19 pandemic has reopened attention on HCQ use and G6PDD. G6PD status is extremely important in modulating the level of reactive oxygen species and many cellular immune responses such as enhanced production of the pro-inflammatory cytokine and inflammasome activation. Since these processes are involved in COVID-19 infection, acute hemolytic anemia, a severe complication of the G6PDD, can occur in these patients. In this context, the role of HCQ, usually effective, safe, and well tolerated in G6PD deficient patients, must be redefined in these patients with COVID-19.As consequence, answering the question: “ Hydroxychloroquine: Culprit or Innocent Bystander in G6PD-Deficient Patients with COVID-19?” , we state that it is risky to believe that HCQ may be an “innocent bystander” in G6PD-deficient COVID-19 patients.

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Section: Discussionmentioning

confidence: 62%

Glucose-6-phosphate dehydrogenase deficiency and hydroxychloroquine in the COVID-19 era: a mini review

et al. 2021

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“…Accumulating evidence points out that cephalosporins could be linked with some forms of autoimmunity. For example, acute and fatal incidences of cephalosporin-induced autoimmune hemolytic anemia have been reported, but the underlying mechanism has not been established [ [47] , [48] , [49] , [50] , [51] ]. Ceftriaxone, especially, has been reported to cause other types of autoimmune reactions like acute autoimmune hepatitis, which could lead to fulminant hepatic failure [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Discovery of new TLR7 agonists by a combination of statistical learning-based QSAR, virtual screening, and molecular dynamics

Abiri

Rezaei

Zeighami

et al. 2021

Informatics in Medicine Unlocked

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“…There is evidence indicating that the long-term use of antibiotics might be related to alterations in the resident oral micro biota and a possible increase in the occurrence of opportunistic microorganisms, such as enteric bacilli, Pseudomonas, Staphylococcus, and yeasts [18] .Sometimes antibodies attack the body's red blood cells and cause them to break down too early which will be led to anemia. Drugs that cause hemolytic anemia are cephalosporins, levo oxacin, penicillin, and its derivatives [19,20] .…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Knowledge and Awareness Among Healthcare Professional Students in Chennai –a Questionnaire-based Online Survey

PACKIRISAMY

Rajendiran³

et al. 2023

Preprint

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Background: Antibiotic resistance had become the greatest threat to modern medicine due to misuse and abuses of antibiotics, when resistance develops against the antibiotics by the microorganism, there will be a need for use of newer, higher efficacy, and more expensive antibiotics. Therefore, Every Health Care Professional student should be Knowledgeable about antibiotics and be aware of antibiotic resistance to prevent harmful effects of antibiotics. Objective: To assess the knowledge and awareness of antibiotics among healthcare professional students, to educate knowledge about antibiotics, and create awareness of antibiotic resistance among healthcare professional students. Methodology: A cross-sectional study was conducted in Chennai, on June28th, 2021.Permission was obtained from IRB; a well-organized questionnaire was executed with 20 items using Google Forms. Pre- structured questions were pre-validated by Experts. Google form contains the details such as socio-demographic, knowledge, and awareness-based questions. The Completed data were collected and entered into an excel sheet and the results were analyzed with the proper statistical method. Results: According to the statistical analysis of data received, only61.34% of healthcare professional students are aware of antibiotics and only 66.26% of healthcare professional students have adequate knowledge about antibiotics. Conclusion: This study highly suggests that awareness camps, seminars, conferences, and lectures, etc., need to be organized for health care professional students to enable them to gain knowledge and awareness about antibiotics. Our study concludes that every Health Care Professional student should be Knowledgeable about antibiotics and be aware of antibiotic resistance to prevent harmful effects of antibiotics.

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Ceftriaxone-Induced Immune Hemolytic Anemia

Cited by 3 publications

References 6 publications

Glucose-6-phosphate dehydrogenase deficiency and hydroxychloroquine in the COVID-19 era: a mini review

Glucose-6-phosphate dehydrogenase deficiency and hydroxychloroquine in the COVID-19 era: a mini review

Discovery of new TLR7 agonists by a combination of statistical learning-based QSAR, virtual screening, and molecular dynamics

Antibiotic Knowledge and Awareness Among Healthcare Professional Students in Chennai –a Questionnaire-based Online Survey

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