Cefuroxime-impregnated cement and systemic cefazolin for 1 week in primary total knee arthroplasty: An evaluation of 2700 knees

Chiang, Chao-Ching; Chiu, Fang-Yao

doi:10.1016/j.jcma.2012.02.016

Cited by 7 publications

(6 citation statements)

References 39 publications

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“…In all studies there were no reports of toxicity or allergies attributed to the use of ALBCs. In addition, the bibliographic research was limited to published comparative studies (ALBC vs PBC) and did not take into account RCTs, RE studies and PRO trials in which there was no control group [5, 9, 18, 22, 27]. Thus, the conclusions of the present review are not absolute.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic-loaded bone cement reduces risk of infections in primary total knee arthroplasty? A systematic review

Panni

Corona

Giulianelli

et al. 2016

Knee Surg Sports Traumatol Arthrosc

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Section: Discussionmentioning

confidence: 99%

Antibiotic-loaded bone cement reduces risk of infections in primary total knee arthroplasty? A systematic review

Panni

Corona

Giulianelli

et al. 2016

Knee Surg Sports Traumatol Arthrosc

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“…More than 90% of surgeons use ALBC in primary TKR in the UK [100], Sweden [101], and Norway [99]. The use of ALBC in knee replacements reduces the percentage of prosthetic infection compared to bone cements lacking antibiotics [102,103].…”

Section: Prophylaxismentioning

confidence: 99%

Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material

Thaher

Perni

Prokopovich

2017

Advances in Colloid and Interface Science

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Total joint replacement (TJR), such as hip and knee replacement, is a popular procedure worldwide. Prosthetic joint infections (PJI) after this procedure have been widely reported, where treatment of such infections is complex with high cost and prolonged hospital stay. In cemented arthroplasties, the use of antibiotic loaded bone cement (ALBC) is a standard practice for the prophylaxis and treatment of PJI. Recently, the development of bacterial resistance by pathogenic microorganisms against most commonly used antibiotics increased the interest in alternative approaches for antimicrobial delivery systems such as nanotechnology. This review summarizes the efforts made to improve the antimicrobial properties of PMMA bone cements using nanotechnology based antibiotic and non-antibiotic delivery systems to overcome drawbacks of ALBC in the prophylaxis and treatment of PJIs after hip and knee replacement.

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“…Several reports showed that pre‐soaking of the graft in vancomycin solution was effective for the prevention of bacterial infection, but those surgeries did not use artificial materials [17, 19, 25, 35]. Antibiotics‐impregnated cement is sometimes used for the prevention of PJI in arthroplasties [5, 6, 22]. Recently, intrawound administration of vancomycin has been performed in various fields.…”

Section: Introductionmentioning

confidence: 99%

Intrawound vancomycin powder increases post-operative wound complications and does not decrease periprosthetic joint infection in primary total and unicompartmental knee arthroplasties

Hanada

Nishikino

Hotta

et al. 2019

Knee Surg Sports Traumatol Arthrosc

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Purpose A frequent reason for revision surgery after total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) is periprosthetic joint infection (PJI). The efficacy of intrawound VP in preventing PJI after primary TKA or UKA is rarely reported. The purpose of this study was to investigate the efficacy and side effects of local high‐dose VP application to the joint to prevent PJI in TKA and UKA. Methods From 2010 to 2017, 166 consecutive patients that underwent primary TKA or UKA were enrolled. Seventy‐five patients (92 knees) did not receive VP (control group), while 90 patients (110 knees, VP group) received VP (intrawound, 1 g) before capsule closure during TKA and UKA. Aseptic wound complications, such as skin erosion, wound dehiscence, and prolonged wound healing, were evaluated within 3 months post‐operatively. PJI was assessed within a year post‐operatively. Results Seven patients (7.6%) in the control group and five patients (4.5%) in the VP group had PJI. No significant differences existed in the PJI rates between the groups. Aseptic operative wound complications occurred in 4 patients (4.3%) and 13 patients (11.8%), whereas prolonged operative wound healing occurred in 3 patients (3.3%) and 14 patients (12.7%) of patients in the control and VP group, respectively. Operative wound complications were significantly frequent in the VP group. Conclusions Intrawound VP administration does not decrease PJI occurrence in primary TKA and significantly causes aseptic wound complications. The use of intrawound VP for the prevention of PJI after primary TKA and UKA is not recommended. Level of evidence Level II.

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Cefuroxime-impregnated cement and systemic cefazolin for 1 week in primary total knee arthroplasty: An evaluation of 2700 knees

Abstract: Comparable with other measurements, cefuroxime-impregnated cement, accompany by systemic cefazolin for 1 week was shown to control postoperative deep infection to 0.19% (after primary TKA was performed in an operative setting without lamina flow and body exhaust suit).

Cited by 7 publications

References 39 publications

Antibiotic-loaded bone cement reduces risk of infections in primary total knee arthroplasty? A systematic review

Antibiotic-loaded bone cement reduces risk of infections in primary total knee arthroplasty? A systematic review

Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material

Intrawound vancomycin powder increases post-operative wound complications and does not decrease periprosthetic joint infection in primary total and unicompartmental knee arthroplasties

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