Cefuroxime in CMW bone cement

Innes, A.; Hughes, Sean; Robertson, Steve; Dash, C. H.

doi:10.1007/bf00266514

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…The strengths of this study are that all results are expressed in quantities. Most authors express their results as concentrations (Innes et al 1985;Vielpeau et al 1980;Wahlig et al 1984) and neglect volumes of drainage fluids and urine. These factors cause inexact or imprecise estimates of blood kinetics and bioavailability.…”

Section: Discussionmentioning

confidence: 96%

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Release of Gentamicin from Acrylic Bone Cement

Bunetel

Segui

Cormier

et al. 1989

Clinical Pharmacokinetics

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The pharmacokinetics of gentamicin were studied after total hip joint arthroplasties performed with "Palacos R plus gentamicin' in 10 patients. Urine was collected at 12-hour intervals for 15 days after operation, and drainage fluids for 48, 72 or 108 hours. Blood samples were taken 3 and/or 5 hours after prosthesis implantation. High concentrations of gentamicin were found in drainage fluids. Excretion curves in drainage fluids or urine were fitted by a computer-aided design program (SIAM) and the mean curves established. Elimination of gentamicin was biphasic in both cases. The rapid phases had a half-life of 2.97 hours in drainage fluids and 7.16 hours in urine. Half-lives of the slow phases were 13.5 and 47.12 hours, respectively. The mean percentage of total gentamicin released by the two routes was 5.78% of the quantity implanted. The calculated peak blood concentration was 0.12 mg/L. It is concluded that gentamicin concentrations locally reach levels higher than minimum inhibitory concentrations of most of the likely pathogens in patients undergoing total hip joint arthroplasties with "Palacos R plus gentamicin' bone cement. However, as blood concentrations appear to be low, patients may not be protected against systemic infections.

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Section: Discussionmentioning

confidence: 96%

“…Previous studies of this topic (Innes et al 1985;Wahlig et al 1984) expressed data mainly in terms of antibiotic concentration. Such an approach is not suitable for evaluation of bioavailability of a drug in bone cement.…”

mentioning

confidence: 98%

Release of Gentamicin from Acrylic Bone Cement

Bunetel

Segui

Cormier

et al. 1989

Clinical Pharmacokinetics

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“…16,38 Their studies showed effective prophylaxis of infection after total joint replacement by cefuroxime in bone cement. The effect of cefuroxime on the mechanical property of cement had been discussed before.…”

Section: Discussionmentioning

confidence: 98%

Cefuroxime-impregnated cement and systemic cefazolin for 1 week in primary total knee arthroplasty: An evaluation of 2700 knees

Chiang¹,

Chiu²

2012

Journal of the Chinese Medical Association

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“…However, despite this, cefuroxime is still a commonly-used prophylactic antibiotic for joint replacement surgery in the UK and has been extensively studied. [25][26][27][28] Patterns of bacterial resistance vary with both time 29 and location. 30,31 However, since 95% of our isolates were sensitive to gentamicin, it seems appropriate to continue the use of this agent in the bone cement used at THA.…”

Section: Discussionmentioning

confidence: 99%

Bacterial contaminants and antibiotic prophylaxis in total hip arthroplasty

Al-Maiyah

Hill

Bajwa

et al. 2005

The Journal of Bone and Joint Surgery. British volume

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We have investigated the contaminating bacteria in primary hip arthroplasty and their sensitivity to the prophylactic antibiotics currently in use. Impressions (627) of the gloved hands of the surgical team in 50 total hip arthroplasties were obtained on blood agar. The gloves were changed after draping, at intervals of 20 minutes thereafter, and before using cement. Changes were also undertaken whenever a visible puncture was detected. The culture plates were incubated at 37 degrees C for 48 hours. Isolates were identified and tested for sensitivity to flucloxacillin, which is a recognised indicator of sensitivity to cefuroxime. They were also tested against other agents depending upon their appearance on Gram staining. We found contamination in 57 (9%) impressions and 106 bacterial isolates. Coagulase-negative staphylococci were seen most frequently (68.9%), but we also isolated Micrococcus (12.3%), diphtheroids (9.4%), Staphylococcus aureus (6.6%) and Escherichia coli (0.9%). Of the coagulase-negative staphylococci, only 52.1% were sensitive to flucloxacillin and therefore to cefuroxime. We believe that it is now appropriate to review the relevance of prophylaxis with cefuroxime and to consider the use of other agents.

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Cefuroxime in CMW bone cement

Cited by 6 publications

References 11 publications

Release of Gentamicin from Acrylic Bone Cement

Release of Gentamicin from Acrylic Bone Cement

Cefuroxime-impregnated cement and systemic cefazolin for 1 week in primary total knee arthroplasty: An evaluation of 2700 knees

Bacterial contaminants and antibiotic prophylaxis in total hip arthroplasty

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