Celiac disease and endocrine autoimmune disorders in children: an update

Diamanti, Antonella; Capriati, Teresa; Bizzarri, Carla; Panetta, Fabio; Ferretti, Francesca; Ancinelli, Monica; Romano, Francesca; Locatelli, Mattia

doi:10.1586/1744666x.2013.850029

Cited by 10 publications

(8 citation statements)

References 105 publications

(194 reference statements)

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“…Several autoimmune diseases are associated with CeD. To date, no conclusive evidence is available that proves if the relationship between CeD and autoimmune diseases is mediated by gluten exposure, or if CeD and autoimmune diseases could occur together due to other causes, particularly the injury of the integrity of the intestinal barrier function and the common genetic background (Table 1 ) [ 3 ]. Genetic studies have identified four shared risk chromosomal loci: PTPN2, IL18RAP, TAGAP, and PUS10 in both diseases [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

et al. 2015

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BackgroundCeliac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period.MethodsTo diagnose celiac disease, serological tests were used, and duodenal biopsy samples were taken to determine the degree of mucosal injury. To set up the diagnosis of inflammatory bowel disease, clinical parameters, imaging techniques, colonoscopy histology were applied. DEXA for measuring bone mineral density was performed on every patient.ResultsIn our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel disease (four males, mean age 37, range 22–67), 6/8 Crohn’s disease, and 2/8 ulcerative colitis. In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel disease was identified during follow-up. The average time period during the set-up of the two diagnosis was 10,7 years. Coeliac disease serology was positive in all cases. The distribution of histology results according to Marsh classification: 1/8 M1, 2/8 M2, 3/8 M3a, 2/8 M3b. The distribution according to the Montreal classification: 4/6 Crohn’s disease patients are B1, 2/6 Crohn’s disease patients are B2, 2/2 ulcerative colitis patients are S2. Normal bone mineral density was detected in 2/8 case, osteopenia in 4/8 and osteoporosis in 2/8 patients.ConclusionsWithin our cohort of patients with coeliac disease, inflammatory bowel disease was significantly more common (3,2 %) than in the general population.

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Section: Discussionmentioning

confidence: 99%

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

et al. 2015

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“…Nevertheless, not all the patients develop multiple autoimmune diseases. The prevalence of CD in T1D has been reported to be 5–7 times higher than in the general population with increased prevalence rates among most ethnic groups , and about 30% of the patients with CD have one or more autoimmune disease . In most patients affected by both diseases together, diabetes has been the first .…”

Section: Introductionmentioning

confidence: 99%

Genetic risk for co‐occurrence of type 1 diabetes and celiac disease is modified byHLA‐C and killer immunoglobulin‐like receptors

et al. 2014

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The prevalence of celiac disease (CD) in patients with type 1 diabetes (T1D) has been reported to be 5-7 times higher than in the general population. Risk factors for co-occurrence of both diseases have not been entirely established. The aim of our study was to analyze possible impact of human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors (KIRs) on the co-occurrence of T1D and CD. We analyzed 67 patients with T1D, 68 patients with CD, 69 patients with both diseases (T1D+CD) and 130 controls. Statistical analysis was based on two tailed Fisher exact test with corrections for multiple testing. After stratification by DR3-DQ2, an association of HLA class I part of the COX haplotype (A1-B8-Cw7-DR3-DQ2) was not observed with each of the studied diseases separately, but it could be shown in case of the co-occurrence of T1D and CD. Only in the group of patients with coexisting diseases, the presence of HLA-C*07 (P = 8.65×10(-3) ) and HLA-B*08 (P = 0.03) but not HLA-A*01 increased the succeptibility. Our current data indicated that C*07, contributing C1 ligand (Pc = 3.67×10(-5) ) rather than B*08, that possesses no KIR ligand, could have an impact on the innate immunity rout of this susceptibility. The significant combination of C1-KIR2DL3 (Pc = 1.97×10(-4) ) observed in patients with coexisting diseases supports this hypotesis. Interestingly, no association was observed when C1 in combination with its stronger inhibitory receptor KIR2DL2 was investigated. Predominantly, weak inhibition in patients with coexisting T1D and CD could lead to a natural killer cell response, making them vulnerable for developing more than one autoimmune disease.

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“…13 CD is characterized by loss of the intestinal epithelial barrier function. 14 Circulating levels of zonulin, a protein that is implicated in the pathogenesis of CD, are elevated in CD and reduced upon instituting a gluten-free diet. 15, 16 Mechanistically, zonulin activates protease-activated receptor 2 (PAR2), a member of the G-protein–coupled receptor family, and induces signaling events that lead to changes in the actin cytoskeleton and cell–cell junctions.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome

et al. 2016

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Case reports have linked childhood nephrotic syndrome to food sensitivity, including gluten. We report our experience with 8 children (6 boys, 2 girls; age at implementation of special diet 2–14 years) with difficult-to-manage nephrotic syndrome who were placed on a gluten-free diet for 3.4 ± 4.3 years (range, 0.6–14 years) and who had clinical improvement enabling reduction or discontinuation in steroid dosage.

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Celiac disease and endocrine autoimmune disorders in children: an update

Cited by 10 publications

References 105 publications

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

Genetic risk for co‐occurrence of type 1 diabetes and celiac disease is modified byHLA‐C and killer immunoglobulin‐like receptors

The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome

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