Celiac disease and its ultimate prognosis

Novel Old Yellow Enzyme Subclasses

“…[7] Subsequently,s everal other yellow enzymes were found, and the first ene reductase was redefined as the "old yellow enzyme"(OYE1). [8] In many cases, the enzymesare important forthe detoxification of electrophilic substances;i ns ome cases, like enzyme YqjM from Bacillus subtilis,t hey play an important role in responding to oxidative stress. [9] Nevertheless, for moste nzymes of the OYE family,t he natural substrates and physiological roles remain unknown.…”

Some Problems in Nutrition

“…For the intervening half century physicians, with a few exceptions (e.g. Haas, 1938;Haas & Haas, 1950;Howland, 1921), have been misled by the results of stool analysis into the belief that failure of fat absorption played a major part in the natural history of the disease. This led them to contribute to the child's starvation by the exclusion from the diet of a high caloric food which could be effectively absorbed.…”

The possible role of dietary factors in the aetiology and pathogenesis of sprue, coeliac disease and idiopathic steatorrhoea

“…Many of the features of the stools-bulk, pallor, semi-fluid consistency, offensive nature and presence of large amounts of short-chain fatty acids-are probably related to fermentative changes; they are likely to be aggravated by a high starch intake and may be improved by restriction or change in the type of carbohydrate ingested, or by an increase of protein intake. Thus, diets containing less starch and more protein (Fairley, 1936)~ or those in which special foods, such as bananas (Haas, 1938)~ were a major component, have been found to be helpful in the management of these patients. It is also likely that these dietary changes resulted accidentally in other modifications, such as reduction in bread intake, which may have had a more specific effect than was appreciated at the time.…”