Celiac disease, collagenous sprue and microscopic colitis in IBD. Observations from a population-based cohort of IBD (ICURE)

Abstract

The risk for celiac disease seems not to be increased in IBD, but those affected by both diseases seem to be predominantly women with extensive UC. There is a potential association between microscopic colitis and IBD.

Microscopic colitis in patients with ulcerative colitis or Crohn’s disease: a retrospective observational study and review of the literature

“…Five patients (two female) with a first diagnosis of UC subsequently developed LC. The age at diagnosis of UC was 35 years, at diagnosis of LC 56 (31-66) years and the time from first to second diagnosis was 29 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) years. Four patients had extensive UC (E3) and one had left-sided disease (E2).…”

“…Thirteen patients with a first diagnosis of MC later developed IBD; 11 CC patients were diagnosed with UC (n ¼ 7) or CD (n ¼ 4), and two patients with LC developed UC (n ¼ 1) or CD (n ¼ 1), respectively. All eight patients who developed UC or IBD-U (unclassified IBD) had extensive colitis (E3) and four patients underwent acute colectomy due to severe colitis 0.5-4 years after an initial MC diagnosis [7,9,15,21].…”

Th1 Pathway: The Missing Link Between Inflammatory Bowel Disease and Microscopic Colitis?

“…These figures are in agreement with two Swedish retrospective reports by Mellander et al [6] or Bohr et al [7] who reported that 2.1 and 1.8% of MC patients had concomitant or delayed IBD and MC diagnoses, respectively. Along the same line, five out of 790 IBD patients (0.6%) developed MC after the IBD diagnosis in the IBD Cohort of Uppsala Health Region (ICURE) study [8]. Interestingly, two of the five patients with MC diagnosed after the IBD diagnosis in the ICURE cohort were also affected by celiac disease [8].…”

“…Along the same line, five out of 790 IBD patients (0.6%) developed MC after the IBD diagnosis in the IBD Cohort of Uppsala Health Region (ICURE) study [8]. Interestingly, two of the five patients with MC diagnosed after the IBD diagnosis in the ICURE cohort were also affected by celiac disease [8]. Therefore, it remains to be established whether there is a demonstrable pathophysiological mechanism that links IBD and MC or if it is mere association.…”

Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

“…Additionally, the presence of mucocutaneous manifestations occurring in DM were also associated with primary sclerosing cholangitis in UC patients31. Moreover, the presence of any autoimmune disorders have also been associated with adverse outcomes of ileal pouch-anal anastomosis32, increased pancolitis3334, and overall increased clinical severity935 in UC patients. These observations give an excellent rationale for future studies to clarify whether UC patients with DM have a more complicated clinical course than those without.…”