Celiac Disease in the Developing World

Barada, Kassem; Daya, Hussein Abu; Rostami, Kamran; Catassi, Carlo

doi:10.1016/j.giec.2012.07.002

Cited by 49 publications

(43 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, CD prevalence among the Iranian population was similar to that among the European and western country populations; this can be because of the lack of knowledge and awareness of CD, attribution of CD symptoms to other similar disease, and low suspicion of CD among physicians in Iran (16,27). For example, results revealed that 12% of patients with irritable bowel syndrome have CD for many years (28).…”

Section: Original Articlesupporting

confidence: 55%

Prevalence of celiac disease among the Iranian population: A systematic review and meta-analysis of observational studies

Ahadi

Shafiee²,

R³

et al. 2016

Turk J Gastroenterol

View full text Add to dashboard Cite

Section: Original Articlesupporting

confidence: 55%

Prevalence of celiac disease among the Iranian population: A systematic review and meta-analysis of observational studies

Ahadi

Shafiee²,

R³

et al. 2016

Turk J Gastroenterol

View full text Add to dashboard Cite

“…Nevertheless, in some Asian nations, CD is still considered to be either non-existent or very rare, but the incidence may be underestimated due to a lack of awareness and low suspicion of the disease [49]. In particular, official reports on CD prevalence in the paediatric Japanese population are absent, but among non-clinical adults the prevalence is about 0.05% [50].…”

Section: Screening Strategies In Paediatric Populationsmentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development. In this review, we discuss the data on the current strategies for CD detection among paediatric populations and the role of questionnaire-based discovery of CD cases in the area of interest. We assume that mass screening is a preferable strategy for finding CD cases within the paediatric population because this could uncover symptomatic, oligosymptomatic, and asymptomatic CD cases. However, under conditions of limited financial resources, screening for CD in risk groups, members of which can be identified using questionnaires, is essential. The pros and cons of CD screening in paediatric populations are presented. These depend on a number of situational criteria (cost-effectiveness, lack of awareness), but screening is designed to improve the detection of the disease and therefore improve the quality of life of patients.

show abstract

“…Cultivation of wheat and barley slowly spread northwestward across Europe to reach Western countries, as Britain, ‘only' 4,000 years ago [26]. The agriculture revolution paved the way to new diseases, such as CD.…”

Section: The Geoepidemiology Of Gluten Consumption and Hla Cd-predispmentioning

confidence: 99%

World Perspective and Celiac Disease Epidemiology

Catassi

Gatti

Lionetti

2015

Dig Dis

Self Cite

112

View full text Add to dashboard Cite

In Europe and the USA, the mean frequency of celiac disease (CD) in the general population is approximately 1%, with some regional differences, the reasons for which remain elusive. A similar disease prevalence has been found in other countries mostly populated by individuals of European origin, e.g. Australia and Argentina. In Western countries, a true rise in overall CD prevalence of CD has been documented. CD is a common disorder in North Africa, the Middle East and India; however, the diagnostic rate is low in these countries due to low availability of diagnostic facilities and poor disease awareness. The highest CD prevalence in the world (5.6%) has been described in an African population originally living in Western Sahara, the Saharawi, of Arab-Berber origin. The reasons for this high CD frequency are unclear but could be primarily related to recent dietary changes and genetic factors, given the high level of consanguinity of this population. Further studies are needed to quantify the incidence of the celiac condition in apparently ‘celiac-free' areas such as Sub-Saharan Africa and the Far East. In many developing countries, the frequency of CD is likely to increase in the near future given the diffuse tendency to adopt Western, gluten-rich dietary patterns. As most cases currently escape diagnosis all over the world, an effort should be made to increase the awareness of CD polymorphism. A cost-effective case-finding policy and new strategies of mass CD screening could significantly reduce the morbidity and mortality associated with untreated disease. The current high prevalence of CD is just the last link in a chain of events started about 10,000 years ago after wheat domestication and diffusion from the Middle East. We hypothesize different mechanisms to explain the so-called evolutionary celiac paradox of co-localization of gluten consumption and HLA CD-predisposing genotypes.

show abstract

Celiac Disease in the Developing World

Cited by 49 publications

References 88 publications

Prevalence of celiac disease among the Iranian population: A systematic review and meta-analysis of observational studies

Prevalence of celiac disease among the Iranian population: A systematic review and meta-analysis of observational studies

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

World Perspective and Celiac Disease Epidemiology

Contact Info

Product

Resources

About