Celiac Disease Prevalence in Brazilian Dilated Cardiomyopathy Patients

de, Ricardo Schmitt; Utiyama, Shirley; Nisihara, Renato; fortunato, Jerônimo Antônio; Tondo, josuÉ Augusto; Carmes, Eliane Ribeiro; Souza, Raquel Almada E.; Pisani, Júlio César; Amarante, Heda Maria Barska dos Santos

doi:10.1007/s10620-006-9337-4

Cited by 34 publications

(23 citation statements)

References 29 publications

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“…However, the number of patients has been relatively small, ranging from 1 to 4 patients with both CD and DCM diagnoses in each study. 12,14,15 The present study identified 17 patients with CD and patient chart–validated idiopathic DCM.…”

Section: Discussionmentioning

confidence: 99%

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Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Emilsson

Andersson

Elfström

et al. 2012

JAHA

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BackgroundDilated cardiomyopathy (DCM) is a rare disease of largely unknown origin. Previous studies have suggested an increased prevalence of celiac disease (CD) in patients with DCM. These studies, however, were based on a maximum of 5 patients with both CD and DCM. In the present large Swedish population-based cohort study, we examined the risk of idiopathic DCM in patients with CD determined by small-intestinal histopathology.Methods and ResultsFrom 2006 to 2008, we collected duodenal/jejunal biopsy data on CD (equal to villous atrophy, Marsh stage 3, n=29 071 unique individuals) from (all) 28 pathology departments in Sweden. These individuals were compared with 144 429 reference individuals matched for age, sex, calendar year, and county. Data on DCM were obtained through the National Patient Register and confirmed by patient charts and echocardiography data. During follow-up, 17 patients with CD and 52 reference individuals developed idiopathic DCM. Thus, patients with CD were at an increased risk of idiopathic DCM (hazard ratio, 1.73; 95% confidence interval, 1.00 to 3.00), although the risk estimate failed to attain statistical significance (P=0.052).ConclusionThis nationwide study found a moderately but not statistically significantly increased risk of idiopathic DCM in patients with biopsy-verified CD. (J Am Heart Assoc. 2012;1:e001594 doi: 10.1161/JAHA.112.001594.)

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Section: Discussionmentioning

confidence: 99%

“…Most research on CD and DCM 12–14 has examined the prevalence of CD in patients with DCM. To our knowledge, only 2 studies have examined the risk of DCM in CD, 15,16 but these studies were restricted to information on CD and DCM from inpatient registers.…”

Section: Introductionmentioning

confidence: 99%

Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Emilsson

Andersson

Elfström

et al. 2012

JAHA

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“…Some studies have reported an increased prevalence of CD in patients with dilated cardiomyopathy (DCM). [78] Frustaci et al . [9] have reported a relatively high CD prevalence in a large cohort of patients with biopsy-proven myocarditis.…”

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confidence: 99%

Cardiac functions assessment in children with celiac disease and its correlation with the degree of mucosal injury: Doppler tissue imaging study

Fathy¹,

Abo‐Haded²,

Al-Ahmadi³

et al. 2016

Saudi J Gastroenterol

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Background/Aims:Celiac disease (CD)-associated cardiologic disorders is a growing concern. However, data regarding cardiac affection in children with CD are few. This study aimed at assessing the subclinical impact of CD on the global myocardial performance in Saudi children with CD using Doppler tissue imaging (DTI).Patients and Methods:Conventional two-dimensional echocardiography was performed among 20 Saudi children with CDas well as 20 age and sex-matched healthy controls. DTI were used to determine right ventricular (RV) and left ventricular (LV) Tei indexes. These findings were correlated with the Modified Marsh Classification of the histologic findings in CD.Results:LV and RV Tei indexes were significantly higher in children with CD than the control group (mean ± standard deviation: 0.47 ± 0.05 vs. 0.31 ± 0.18; P < 0.0005 and 0.51 ± 0.04 vs. 0.32 ± 0.05; P < 0.0001, respectively). RV Tei index was found to be positively correlated with the Modified Marsh Classification of CD (r = 0.7753, P < 0.0001). LV Tei index tended to be more affected in patients with more severe histologic findings, however, such relation did not reach statistical significance (r = 0.2479, P = 0.292). Fractional shortening did not correlate with the Modified Marsh Classification of histologic findings in CD patients (r= −0.11, P = 0.641).Conclusions:Subclinical myocardial dysfunction of both ventricles occurs in children with CD. The DTI method appears to be more sensitive than conventional two-dimensional echocardiography in the early detection of myocardial dysfunction in children with CD.

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“…However, there have been few attempts to systematically study such a link. Some studies have searched for coeliac disease in cohorts of patients with dilated cardiomyopathy and reported the prevalence of coeliac to be higher than would be expected in the general population 14 15. However, other studies of dilated cardiomyopathy patients have not found any increased prevalence of coeliac disease 16…”

Section: Discussionmentioning

confidence: 99%

Cardiomyopathy responsive to gluten withdrawal in a patient with coeliac disease

2016

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A 57-year-old man with iron deficiency anaemia developed general malaise, exertional dyspnoea and features of cardiac failure out of proportion to his anaemia (haemoglobin 120 g/L). Investigations showed a severely dilated left ventricle with an ejection fraction of 15%, due to dilated cardiomyopathy. He was treated with high-dose diuretics, ACE inhibitors and β-blocker therapy. Subsequent investigation into his iron deficiency anaemia revealed a new diagnosis of coeliac disease. After starting a gluten-free diet, his cardiac function improved markedly, with ejection fraction reaching 70%, allowing his cardiac medications to be withdrawn. This case suggests a link between coeliac disease and cardiomyopathy.

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Celiac Disease Prevalence in Brazilian Dilated Cardiomyopathy Patients

Cited by 34 publications

References 29 publications

Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Risk of Idiopathic Dilated Cardiomyopathy in 29 000 Patients With Celiac Disease

Cardiac functions assessment in children with celiac disease and its correlation with the degree of mucosal injury: Doppler tissue imaging study

Cardiomyopathy responsive to gluten withdrawal in a patient with coeliac disease

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