Celiac disease-related hepatic injury: Insights into associated conditions and underlying pathomechanisms

Marcianò, F.; Savoia, Marcella; Vajro, Pietro

doi:10.1016/j.dld.2015.11.013

Cited by 52 publications

(53 citation statements)

References 102 publications

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“…We also detected an association between high autoantibody values and increased ALT, which is in line with the known correlation between serology and histology in celiac disease [46]. However, there is also evidence to indicate that the antibodies might in fact participate in the pathogenesis [10,11,47]. If proven, this would further emphasize the importance of early diagnosis.…”

Section: Discussionsupporting

confidence: 84%

“…The major reason for the improved diagnostic efficacy is recognition of the diversity of the clinical picture, including a variety of extra-intestinal symptoms [6,7]. One of the best-characterized of these is hypertransaminasemia [8][9][10][11], the prevalence of which in untreated adults has been up to 42% [12][13][14]. Only a limited number of studies have been conducted in children, but the percentages have been generally comparable to those reported in adults [9,15,16].…”

Section: Introductionmentioning

confidence: 84%

See 1 more Smart Citation

Prevalence and associated factors of abnormal liver values in children with celiac disease

Äärelä

Nurminen

Kivelä

et al. 2016

Digestive and Liver Disease

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 84%

Prevalence and associated factors of abnormal liver values in children with celiac disease

Äärelä

Nurminen

Kivelä

et al. 2016

Digestive and Liver Disease

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“…The diagnosis of PBC can be established when two of the following three criteria are met – biochemical evidence of cholestasis based mainly on alkaline phosphatase elevation, the presence of antimitochondrial antibody and histologic evidence of non-suppurative destructive cholangitis and destruction of interlobular ducts. The antimitochondrial antibody is a highly disease-specific autoantibody found in up to 95% of patients with PBC [1-2]. Fatigue is the most common clinical manifestation of PBC and is present in up to 80% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Celiac disease is a systemic inflammatory disease secondary to gluten sensitivity in the presence of antibodies to tissue transglutaminase and is rarely associated with liver disease such as primary biliary cholangitis. The classical celiac disease association with liver disease is that of abnormal transaminases that normalize on a gluten-free diet [1]. We present the case of a 62-year-old man with primary biliary cholangitis and atypical skin lesions diagnosed as a case of dermatitis herpetiformis associated with gluten sensitivity, a rare association.…”

Section: Introductionmentioning

confidence: 99%

Dermatitis Herpetiformis as the Initial Presentation of Primary Biliary Cholangitis in a Male with Gluten Sensitivity

Philips

Paramaguru

Indiran³

et al. 2017

Cureus

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Celiac disease is commonly associated with elevated liver enzymes that normalize on a gluten-free diet. Celiac disease is rarely described in patients with primary biliary cholangitis. Dermatitis herpetiformis is the skin manifestation of the celiac disease that is very rarely associated with primary biliary cirrhosis. We present the case of a 62-year-old man who presented with severe chronic pruritus, in whom a diagnosis of primary biliary cholangitis was made initially. However, in the presence of atypical skin lesions, not confirming to chronic cholestasis, an in-depth evaluation including histopathological examination led to the diagnosis of dermatitis herpetiformis associated with gluten sensitivity. Gluten-free diet and medical treatment with dapsone led to beneficial clinical outcomes.

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“…Çölyak hastalığı birçok farklı mekanizmanın bir arada bulunmasıyla karaciğer hasarına yol açabilir (6). Diyetten glutenin çıkarılması ile transaminazların normale dönmesi; ÇH ile karaciğer hasarı arasındaki ilişkiyi desteklemektedir.…”

Section: çöLyak Hastaliği Karaci̇ğer İli̇şki̇si̇: Patogeneti̇k Mekani̇zmalarunclassified

Liver manifestations of Celiac disease

Düzenli¹,

Tanoğlu²

2017

İstanbul Tıp Fakültesi Dergisi

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ÖZETÇölyak hastalığı (ÇH) buğdaydaki glutene ve arpa, çavdar, yulaf gibi tahıllarda bulunan gluten benzeri diğer tahıl proteinlerine karşı kalıcı intoleransla karekterize, ağırlıklı olarak proksimal ince barsağı etkileyen bir hastalıktır. Bir enteropati olarak bilinmesine rağmen son yıllarda ortaya konulan ve belirginleşen gastrointestinal sistem dışı bulguları ile de kendini göstermektedir. ÇH, karaciğer enzim yüksekliklerinin %6-9'unu oluştururken, ÇH olanlarda ise karaciğer enzimlerindeki yükselme oranı %40' lara varabilmektedir. ÇH'nda tek bulgu bazen karaciğer enzim yüksekliği olabildiği gibi; birçok karaciğer hastalığı ile ÇH birlikteliği de gösterilmiştir. Bu kapsamda ÇH tanısı konan hastalarda mutlaka karaciğer enzim taraması önerilmektedir. ÇH ilişkili karaciğer bozuklukları kriptojenik hipertransaminazemi ya da çölyak hepatiti ve otoimmün karaciğer hastalıkları olarak iki ana grupta değerlendirilebilir. Bunların yanında birçok karaciğer hastalığı ile de ÇH birlikteliği gösterilmiştir. Bu yazımızda ÇH ile karaciğer enzim yüksekliği ilişkisini inceleyerek, bu hastalıklara yaklaşımı özetlemeyi hedefledik. Anahtar Kelimeler: Çölyak hastalığı; Gluten; karaciğer ABSTRACTCeliac disease (CD) is characterized by persistent intolerance to wheat gluten and other gluten-like proteins found in cereals such as barley, rye, and oats. It predominantly affects the proximal small intestine. Although CD is known as an enteropathy, an increasing number of extraintestinal manifestations have appeared in recent years. Although CD accounts for 6%-9% of elevated hepatic enzymes, hypertransaminasemia can be seen in 40% of CD patients. Although the only finding could be hypertransaminasemia, many liver diseases and CD co-morbidities have also been demonstrated. In this regard, hepatic enzyme screening is recommended for patients diagnosed with CD. CD-related liver disorders may be categorized into two main groups: cryptogenic hypertransaminase/celiac hepatitis and autoimmune liver diseases. In addition, many liver diseases can be associated with CD. In this article, we aimed to summarize the relation between CD and liver enzyme elevation and the approach to treating hypertransaminasemia in CD patients.

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Celiac disease-related hepatic injury: Insights into associated conditions and underlying pathomechanisms

Cited by 52 publications

References 102 publications

Prevalence and associated factors of abnormal liver values in children with celiac disease

Prevalence and associated factors of abnormal liver values in children with celiac disease

Dermatitis Herpetiformis as the Initial Presentation of Primary Biliary Cholangitis in a Male with Gluten Sensitivity

Liver manifestations of Celiac disease

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