Prevalence and associated factors of abnormal liver values in children with celiac disease

Extraintestinal manifestations were common in children with coeliac disease and were more prevalent in patients with more severe clinical and histological presentation

“…In our earlier study, 15% of children with untreated coeliac disease had elevated alanine aminotransferase values and even higher rates have been reported . Nevertheless, this study used a higher cut‐off for increased values than our previous study, as mild hypertransaminasaemia usually has no major clinical significance . In contrast to the above‐mentioned symptoms, mouth and teeth findings were quite rare.…”

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

“…37 Other possible complications which have been observed regardless of the clinical presentation of celiac disease are for instance low bone mineral density, dental enamel defects and elevated transaminases. 21,22,29,38 Further supporting the presence of advanced disease and risk of complications, the screen-detected children here had levels of celiac disease autoantibodies and severity of villous atrophy similar to those detected on clinical basis. It is possible that, despite equal severity of histological injury, the clinically detected group had longer length of small intestinal injury, which may explain their apparent gastrointestinal symptoms.…”

“…blood hemoglobin (Hb) (g/l), erythrocyte mean corpuscular volume (MCV) (reference value (Rf) 73-95 fl), plasma albumin (Rf 36-48 g/l), plasma transferrin receptor (TfR) (age-and sex-matched Rf), 28 plasma ferritin (Rf >20 µg/l), plasma alanine aminotransferase (ALT) (Rf ≤30 U/l) 29 and plasma thyroid-stimulating hormone (TSH) (Rf 0.27-4.2 mU/l). Anemia was defined as a Hb value below the age-and sex-matched reference.…”

Extraintestinal Manifestations Associated with Celiac Disease

“…Gluten exposure time, dietary compliance, iron, vitamin and mineral deficiencies as well as immunological disorders are suggested as the causes of oral involvement (27). Elevated liver enzymes and autoimmune liver diseases such as autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis are also frequently reported in celiac patients (2). The incidence of hypertransaminemia in celiac patients has been reported in 9-14% of recent studies.…”

“…However, malabsorption related symptom ratio decreased in newly diagnosed patients and became prominent non-classical or even asymptomatic celiac disease (CD) (1). Celiac patients can be affected almost all organs of the body, including the nervous system, liver, skin, reproductive and musculoskeletal systems (2,3). Diagnosis of CD with the use of highly sensitive and specific serological test, has become more common.…”