Celiacs Disease Is Not a Major Risk Factor for the Development of Childhood Idiopathic Thrombocytopenic Purpura

Rischewski, Johannes; Paulussen, Michael; Kühne, Thomas

doi:10.1097/mph.0b013e31815d9d2c

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Previous case series by Sarbay et al [ 22 ] reported a lower prevalence (3.4%, 1/29), and Rischewski et al reported the absence of CD (0/21) among ITP patients [ 21 ]. The discrepancy observed between our study and the two case series analyzed by Sarbay et al and Rischewski et al may be partially explained by sampling bias given the small size of cohorts and the rarity of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study

Bibbò

Fozza

Pes

et al. 2018

Gastroenterology Research and Practice

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Introduction Coeliac disease (CD) and immune thrombocytopenic purpura (ITP) are immune conditions, often associated with other immune disorders. In recent years, increasing attention has been directed towards the association between ITP and CD. Aim To investigate the frequency of ITP in CD patients and vice versa and to assess the risk of their association. Patients and Methods This was a prospective observational study. All consecutive patients with CD or ITP attending our department were enrolled between January 2016 and December 2017. All patients with CD were screened for ITP and patients with ITP for CD. Odds ratios (ORs) were calculated based on the prevalence in the general population. Results Two hundred sixty-one CD patients (212 female, mean age 47 ± 16.1 years) and 32 ITP patients (17 female, mean age 57.8 ± 17.4 years) were enrolled. In the CD cohort, two patients (2/261; 0.8%) reported a previous diagnosis of ITP, compared to the general population; OR was 15.3 (95% CI, 3.82–61.73; p < 0.0001). Similarly, in the ITP cohort, two patients (2/32; 6.3%) had a previous diagnosis of CD (OR: 9.89, 95% CI, 2.27–43.16; p = 0.0002). Discussion A greater frequency of ITP in coeliac patients and vice versa was observed in our study, suggesting an increased risk for patients of developing both disorders.

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Section: Discussionmentioning

confidence: 99%

“…Afterwards, two smaller observational studies showed contradictory results. For example, in a cohort of 21 children with ITP from Switzerland, Rischewski et al were not able to find any case of CD [ 21 ], while in a more recent study, Sarbay and colleagues observed one case of CD in a group of 29 ITP patients [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study

Bibbò

Fozza

Pes

et al. 2018

Gastroenterology Research and Practice

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show abstract

“…In literature, CD as a risk factor for the development of ITP is controversial. Rischewski et al 6 . investigated the co‐occurrence of CD and ITP/Evans syndrome in a pilot study, and concluded that neither typical nor atypical CD is a major risk factor for the development of ITP.…”

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confidence: 99%

Immune Thrombocytopenic Purpure and Coeliac Disease

Hammami

Hadded

Lajmi

et al. 2011

J Paediatrics Child Health

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“…Immune thrombocytopenia (ITP) is an acquired disease caused by autoantibodies against platelet antigens whose estimated yearly incidence in the pediatric population is 0.0019%-0.0064% [ 3 ]. The features of ITP and CD coexistence have been investigated in some cohorts and case reports with contradictory results, especially regarding the efficacy of a gluten-free diet on ITP [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Furthermore, no study has aimed to describe the specific features of this association in the pediatric population.…”

Section: Introductionmentioning

confidence: 99%

Association of Immune Thrombocytopenia and Coeliac Disease in Children (Retrospective Case Control Study)

Guarina¹,

Marinoni²,

Lassandro³

et al. 2021

Tjh

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Objective: The association between celiac disease (CD) and immune thrombocytopenia (ITP) is still uncertain. The aim of this study was to characterize the coexistence of these two diseases in Italian children. Materials and Methods: This is a retrospective multicenter study investigating the occurrence of CD in 28 children with ITP diagnosed from January 1, 2000, to December 31, 2019. Results: The first diagnosis was ITP in 57.1% and CD in 32.1% of patients. In 3 patients (10.7%), the two diagnoses were simultaneous. All the potential and silent cases of CD in our cohort were diagnosed in the groups of “ITP first” and “simultaneous diagnosis”. In all children ITP was mild, and in 2 out of 8 not recovered from ITP at the time of CD diagnosis a normalization of platelet counts (>100,000/μL) occurred 3 and 5 months after starting a gluten-free diet, respectively. Conclusion: We think that screening for CD should be considered in children with ITP regardless of the presence of gastrointestinal symptoms. Furthermore, some patients may recover from ITP after starting a gluten-free diet.

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Celiacs Disease Is Not a Major Risk Factor for the Development of Childhood Idiopathic Thrombocytopenic Purpura

Cited by 4 publications

References 12 publications

Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study

Increased Frequency of Immune Thrombocytopenic Purpura in Coeliac Disease and Vice Versa: A Prospective Observational Study

Immune Thrombocytopenic Purpure and Coeliac Disease

Association of Immune Thrombocytopenia and Coeliac Disease in Children (Retrospective Case Control Study)

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