Cell apoptosis and proliferation in salivary glands of Sjögren’s syndrome

Busamia, Beatriz; González‐Moles, Miguel Ángel; Ruiz‐Ávila, Isabel; Brunotto, Mabel; Gil-Montoya, José Antonio; Bravo, Manuel; Gobbi, Carla; Finkelberg, A.

doi:10.1111/j.1600-0714.2011.01042.x

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…The sensation of dry mouth in these patients has been attributed to a variety of factors, including atrophy and a reduced number of acini as well as ducts due to augmented apoptosis [1,3], glandular denervation [4], inhibition of neurotransmitter release by cytokines [5], enhanced breakdown of acetylcholine by increased levels of cholinesterase [6], blockade of M3 muscarinic receptor by anti-muscarinic auto-antibodies [6], altered NO production [7], perturbation of calcium-induced calcium release by altered levels of cADPr (possibly as a result of altered NO levels) [7], altered Ca 2þ tunneling [8] and altered expression or distribution of AQP5 [9]. All these factors are related to water transport from acinar cells to the lumen of salivary glands [8].…”

Section: Introductionmentioning

confidence: 99%

Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren’s syndrome patients is linked to ectopic mucin secretion

Barrera

Sánchez

Aguilera

et al. 2012

Journal of Autoimmunity

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Section: Introductionmentioning

confidence: 99%

Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren’s syndrome patients is linked to ectopic mucin secretion

Barrera

Sánchez

Aguilera

et al. 2012

Journal of Autoimmunity

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“…Such idiosyncrasies include disturbed cell proliferation/apoptosis regulation and increased breakdown of secreted proteins [31]. …”

Section: Methodsmentioning

confidence: 99%

“…Apoptosis, either in a direct or indirect way, is involved in the development of secretory dysfunction affecting the exocrine lachrymal and salivary glands [31]. Two factors associated with acinar tissue apoptosis include the proteolysis of α-fodrin and the Fas/Fas-ligand interaction [32].…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, the interaction Fas/Fas-L could also contribute to the activation of apoptotic pathways in SS, by inducing the downstream activation of proteinases and caspases, which lead to the fragmentation of DNA. It has been shown that SS-affected individuals are able to express the Fas antigen in their ductal epithelial cells, providing that this cellular population is a good target for effector T cells-mediated induction of apoptosis [31]. Effector T cells also are able to induce apoptosis through the release of proteases such as perforin and granzyme B [34].…”

Section: Methodsmentioning

confidence: 99%

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Advances in the Aetiophatogenesis of Sjögren’s Syndrome: a Literature Review

Gomes¹,

Juodžbalys²,

Fernandes³

et al. 2012

JOMR

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ObjectivesThe purpose of present paper is to review and critically address the recent advances on the aetiopathogenesis of the Sjögren’s syndrome, taking into account the attained clinical features, with particular relevance given to the oral involvement.Material and MethodsA comprehensive review of the available literature between 1970 and 2012, regarding to the aetiopathogenesis and clinical findings related to Sjögren’s syndrome was conducted. Eligible studies were identified by searching the electronic literature PubMed, Medline, Embase, and ScienceDirect databases for relevant reports (last search update January 2012), combining the MESH heading term "Sjögren’s syndrome", with the words "salivary glands, xerostomia, xerophtalmia, aetiology". The authors checked the references of the selected articles to identify additional eligible publications and contacted the authors, if necessary.ResultsThis article addresses a large number of the recent advances in the aetiopathogenesis of the disease, taking into account the attained clinical features of both local and systemic nature. Detailed mechanisms of the hypothesized influence of viral infections, genetic and hormonal factors, and the relevance of the altered glandular homeostasis are critically discussed with particular relevance given to the local and systemic involvement of Sjögren’s syndrome.ConclusionsThe increasing number of data published recently on the aetiophatogenesis of Sjögren’s syndrome strengthens the hypothesis that this condition, as all autoimmune diseases, is a multifactor disorder. Genetic predisposition, hormonal and environmental factors are thought to be implicated.

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“…pSS occurs in individuals with no other types of rheumatic disease (5,6) and sSS occurs in individuals who have another type of rheumatic disease, which is most often systemic lupus erythematosus or rheumatoid arthritis (7)(8)(9). SS predominantly affects the salivary and lacrimal glands and further results in dry eyes and, in particular, dry mouth (10)(11)(12). The damage to the salivary glands in SS cannot be reversed, but the symptoms are controllable.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of Zeng Ye decoction on primary Sjögren’s syndrome via upregulation of aquaporin-1 and aquaporin-5 expression levels

Ren

Zhou

et al. 2014

Molecular Medicine Reports

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The aim of this study was to investigate the curative effect of Zeng Ye decoction on primary Sjögren's syndrome (pSS) and further explore its underlying mechanism involving aquaporin (AQP)‑1 and AQP‑5. The pSS model was established based on the immune induction method, and the saliva flow, submandibular gland index, morphological structures of salivary glands, and AQP‑1 and AQP‑5 protein expression levels in the salivary glands were determined. The saliva flow and the submandibular gland index were significantly reduced in the model group (P<0.01, compared with those in the control group), and significantly increased following interferon (IFN), Zeng Ye decoction extraction (ZYE) and Zeng Ye decoction (ZY) treatment (P<0.01, compared with those of the model group). Submandibular gland atrophy, fibrous tissue hyperplasia and multiple focal lymphocytic infiltration were observed in the model group and were attenuated when subjected to IFN, ZYE and ZY treatment. The AQP‑1 and AQP‑5 expression levels increased following IFN, ZYE and ZY treatment (P<0.01, compared with those of the model group), particularly in the ZYE‑35 group. This result indicated that ZYE had a significant protective effect on pSS via upregulation of the expression levels of AQP‑1 and/or AQP‑5. However, the AQP‑1 expression levels increased and the AQP‑5 expression levels decreased in the model groups compared with those in the control group, which indicated different regulatory pathways of the salivary gland damage on the basis of AQP‑1 and AQP‑5. This study provided a significant reference for the prevention and treatment of pSS.

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Cell apoptosis and proliferation in salivary glands of Sjögren’s syndrome

Cited by 10 publications

References 16 publications

Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren’s syndrome patients is linked to ectopic mucin secretion

Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren’s syndrome patients is linked to ectopic mucin secretion

Advances in the Aetiophatogenesis of Sjögren’s Syndrome: a Literature Review

Therapeutic effect of Zeng Ye decoction on primary Sjögren’s syndrome via upregulation of aquaporin-1 and aquaporin-5 expression levels

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