The results of this work are indicative of a high degree of proliferation (85%) in infiltrated lymphocytes (IL) associated with SS which, according the literature, could be considered a risk. Furthermore, the markers used in this work are widely known and represent a lower cost than others and can be used to determine risk groups within the population of SS patients, enabling their follow-up.
The aim of this study was to assess changes in salivary electrolyte flow and composition and the presence of anti-Ro/SSA and anti-La/SSB serum and saliva antibodies and their implications for the non-invasive diagnosis of SS. Study design: 73 patients were studied, divided into the following experimental groups: primary Sjögren syndrome (SSp) (n=15), secondary SS (SSs) (n=17), dry mouth, dry eye without Sjögren's syndrome (BO) (n=20) and healthy controls (C) (n=21). We conducted a baseline assessment of salivary flow and saliva sampling for the measurement of sodium, chlorine, potassium, calcium and phosphate electrolytes, and the determination of antiRo/SSA and La/SSB antibodies; a serum sampling was made to assess antibody positivity. Results: Salivary flow in SSp, SSs and BO was significantly lower (p<0.001) relative to C. The salivary composition of SS showed an increase of inorganic components. Anti-Ro/SSA and anti-La/SSB antibodies occurred more frequently in serum and saliva in SS patients compared with BO and C, with higher frequency of positivity in serum compared with saliva. Conclusion: Our results suggest new tools that could aid the non-traumatic diagnosis of the origin of hyposalivation.
Han aumentado las técnicas para la examinación clínica e imagenológica de las articulaciones temporomandibulares, sin embargo, no sucede lo mismo en la posibilidad de evaluación en la anamnesis cotidiana en la consulta de rutina. Existen muy pocos cuestionarios y la mayoría son antiguos. Objetivo: Utilizar una herramienta útil y práctica para las interconsultas y derivaciones de pacientes entre el Servicio de Reumatología y el Servicio de Odontología. Material y métodos: Se implementó el Cuestionario para evaluar las disfuncionalidades de las articulaciones temporomandibulares en artritis reumatoide (CEDATAR) para evaluar si presentaba la capacidad de detectar alteraciones en las articulaciones que le sirvieran a los distintos profesionales en la decisión de derivar a un especialista al paciente. Resultados: Se evidenció que todos los pacientes que acusaron alteraciones en las respuestas del cuestionario, al corroborarse presentaron modificaciones importantes en el análisis imagenológico y/o clínico. Conclusiones: La artritis reumatoide es una enfermedad declarada de importancia en salud pública y políticas sanitarias, es de imponderable relevancia la utilización de CEDATAR en las consultas reumatológicas cotidianas para agilizar las terapéuticas limitando el avance de la enfermedad autoinmune a nivel de las articulaciones temporomandibulares suministrando un pronóstico más favorable y limitando lesiones y discapacidades.
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