Cell-Based Therapy for Tooth Replantation Following Avulsion: A Systematic Review

Chew, Jacob Ren Jie; Tan, Bing Liang; Lu, Jacinta Xiaotong; Tong, Huei Jinn; Duggal, M. S.

doi:10.1089/ten.teb.2021.0016

Cited by 5 publications

(4 citation statements)

References 51 publications

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“…A recent systematic review investigated the outcomes of cell-based approaches for the tooth replantation using animal models and reported that the replacement root resorption and ankylosis ranged from 20.8 to 100% in the cell-free control group and 0 to 38.4% in the cell-based groups suggesting the potential of cell-based approach for the management of avulsed teeth [ 41 ].…”

Section: Cell-based Pdl Regeneration For Avulsed Teethmentioning

confidence: 99%

“…The progress of regeneration research, especially cell therapy, has provided much possibility to overcome the limitations and challenges that non cell-based therapy has faced in many medical conditions. To advance the treatment of avulsed teeth, especially those that the PDL has been dry and severely damaged/lost, we must take advantage of what stem cell-mediated approach can provide [ 41 ]. Without taking such a leap, management of avulsed teeth will continue to be stagnated.…”

Section: Prospect and Conclusionmentioning

confidence: 99%

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A new direction in managing avulsed teeth: stem cell-based de novo PDL regeneration

et al. 2022

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Management of avulsed teeth after replantation often leads to an unfavorable outcome. Damage to the thin and vulnerable periodontal ligament is the key reason for failure. Cell- or stem cell-based regenerative medicine has emerged in the past two decades as a promising clinical treatment modality to improve treatment outcomes. This concept has also been tested for the management of avulsed teeth in animal models. This review focuses on the discussion of limitation of current management protocols for avulsed teeth, cell-based therapy for periodontal ligament (PDL) regeneration in small and large animals, the challenges of de novo regeneration of PDL on denuded root in the edentulous region using a mini-swine model, and establishing a prospective new clinical protocol to manage avulsed teeth based on the current progress of cell-based PDL regeneration studies.

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Section: Cell-based Pdl Regeneration For Avulsed Teethmentioning

confidence: 99%

Section: Prospect and Conclusionmentioning

confidence: 99%

A new direction in managing avulsed teeth: stem cell-based de novo PDL regeneration

et al. 2022

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“…A recent systematic review evaluated the efficacy of cell-based therapy in promoting periodontal healing in replanted animal models (Chew et al, 2021). This review reported that cell-based therapy increases the proportion of roots displaying periodontal healing and reduces replacement root resorption and ankylosis.…”

Section: Cell-based Approaches For Regeneration Of Pdl After Replanta...mentioning

confidence: 99%

Tooth transplantation and replantation: Biological insights towards therapeutic improvements

Ideno

Komatsu

Nakashima

et al. 2022

Genesis

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Summary Transplantation and replantation of teeth are effective therapeutic approaches for tooth repositioning and avulsion, respectively. Transplantation involves transplanting an extracted tooth from the original site into another site, regenerating tissue including the periodontal ligament (PDL) and alveolar bone, around the transplanted tooth. Replantation places the avulsed tooth back to its original site, regenerating functional periodontal tissue. In clinical settings, transplantation and replantation result in favorable outcomes with regenerated PDL tissue in many cases. However, they often result in poor outcomes with two major complications: tooth ankylosis and root resorption. In tooth ankylosis, the root surface and alveolar bone are fused, reducing the PDL tissue between them. The root is subjected to remodeling processes and is partially replaced by bone. In severe cases, the resorbed root is completely replaced by bone tissue, which is called as “replacement resorption.” Resorption is sometimes accompanied by infection‐mediated inflammation. The molecular mechanisms of ankylosis and root resorption remain unclear, although some signaling mechanisms have been proposed. In this mini‐review, we summarized the biological basis of repair mechanisms of tissues in transplantation and replantation and the pathogenesis of their healing failure. We also discussed possible therapeutic interventions to improve treatment success rates.

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“…The fibrin network of PRF protects platelets from immediate activation but progressively activates them during the process of fibrin degradation, slowly releasing growth factors, eventually prolonging the duration of growth factors in PRF and promoting wound healing effects[ 13 , 14 ]. Thus, PRF has the potential to enhance tissue regeneration, accelerate wound healing and induce stem cell differentiation through the consistent release of multiple growth factors[ 15 , 16 ]. Our previous study demonstrated that autologous PRF could effectively promote the periodontal healing of avulsed teeth after delayed replantation in dogs and thus control the occurrence and development of initial root resorption[ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Rescuing “hopeless” avulsed teeth using autologous platelet-rich fibrin following delayed reimplantation: Two case reports

Yang¹,

Li²,

Jia³

et al. 2023

World J Clin Cases

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BACKGROUND Tooth avulsion is one of the most severe types of dental trauma. Most avulsed teeth undergo long-term ankylosis and replacement resorption after delayed reimplantation and exhibit a poor prognosis. The aim of this work was to improve the success rate of avulsed teeth after delayed reimplantation using autologous platelet-rich fibrin (PRF). CASE SUMMARY Case 1 was a 14-year-old boy who fell and knocked out his left upper central incisor 18 h prior to his arrival at the department. The diagnoses were avulsion of tooth 21, lateral luxation of tooth 11 and alveolar fracture of teeth 11 and 21. In case 2, a 17-year-old boy fell 2 h prior to his presentation to the hospital, and his left upper lateral incisor was completely knocked out of the alveolar socket. The diagnoses included avulsion of tooth 22, complicated crown fracture of tooth 11 and complicated crown-root fracture of tooth 21. The avulsed teeth were reimplanted along with autologous PRF granules and splinted using a semiflexible titanium preshaped labial arch. The root canals of the avulsed teeth were filled with calcium hydroxide paste, and root canal ﬁlling was performed 4 wk after reimplantation. The reimplanted teeth showed no symptoms of inﬂammatory root resorption or ankylosis at the 3-, 6-, and 12-mo follow-up examinations after reimplantation with autologous PRF. In addition to the avulsed teeth, the other injured teeth were treated using corresponding conventional treatment methods. CONCLUSION These cases provide examples of the successful use of PRF to reduce pathological root resorption of the avulsed teeth, and the application of PRF may provide new healing opportunities for traditionally “hopeless” avulsed teeth.

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Cell-Based Therapy for Tooth Replantation Following Avulsion: A Systematic Review

Cited by 5 publications

References 51 publications

A new direction in managing avulsed teeth: stem cell-based de novo PDL regeneration

A new direction in managing avulsed teeth: stem cell-based de novo PDL regeneration

Tooth transplantation and replantation: Biological insights towards therapeutic improvements

Rescuing “hopeless” avulsed teeth using autologous platelet-rich fibrin following delayed reimplantation: Two case reports

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