2004
DOI: 10.1007/s00795-004-0261-4
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Cell biology and pathology of liver sinusoidal endothelial cells

Abstract: Growing evidence revealed that liver sinusoidal endothelial cells (SEC) play several important roles in physiology and pathology of the liver. It has been well understood that their structural characteristics, such as the membrane sieve and lack of basement membrane, facilitate direct contact of soluble and insoluble serum substances with hepatic parenchymal cells, resulting in enhancement of hepatic metabolic activity. In addition, SEC is now regarded as a member of the scavenger endothelial cells, which have… Show more

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Cited by 66 publications
(42 citation statements)
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“…This hepatic sinusoidal immune system involves the hepatic-specific natural killer cells (NK) (pit cells) [3] , Kupffer cells (KC) (liver-associated macrophages) [4] and hepatic endothelial cells (HEC) [5] , and is proven to play an important role in protecting the liver from invading colon carcinoma cells [6] . The conventional paradigm of CRC liver metastasis is based on a multi-step process characterized by a series of structural, cellular and molecular events, which give the tumour cells the ability to proceed through the many phases of liver metastasis.…”
Section: Colorectal Cancer and The Hepatic Sinusoidal Immune Systemmentioning
confidence: 99%
“…This hepatic sinusoidal immune system involves the hepatic-specific natural killer cells (NK) (pit cells) [3] , Kupffer cells (KC) (liver-associated macrophages) [4] and hepatic endothelial cells (HEC) [5] , and is proven to play an important role in protecting the liver from invading colon carcinoma cells [6] . The conventional paradigm of CRC liver metastasis is based on a multi-step process characterized by a series of structural, cellular and molecular events, which give the tumour cells the ability to proceed through the many phases of liver metastasis.…”
Section: Colorectal Cancer and The Hepatic Sinusoidal Immune Systemmentioning
confidence: 99%
“…( Sinusoidal endothelial cells (SECs) of the liver are specialized endothelial cells that play important roles in maintaining normal liver functions through interaction with hepatocytes and other nonparenchymal cells. 1,2 Various pathological conditions of the liver, such as septic shock and reperfusion injury after ischemia, have been shown to be associated with death of SECs. [1][2][3][4] Many reports have demonstrated that SEC damage during cold or warm preservation of the liver hampers the outcome of liver transplantation.…”
mentioning
confidence: 99%
“…1,2 Various pathological conditions of the liver, such as septic shock and reperfusion injury after ischemia, have been shown to be associated with death of SECs. [1][2][3][4] Many reports have demonstrated that SEC damage during cold or warm preservation of the liver hampers the outcome of liver transplantation. [5][6][7] Several lines of evidence have shown that death of SECs in those adverse conditions is executed by apoptosis.…”
mentioning
confidence: 99%
“…Sinusoidal endothelial cells differ from other endothelial cells by the lack of a subjacent basal lamina (De Leeuw et al 1990;Wake 1999). These cells have a scavenger function by eliminating macromolecules through endocytosis (Elvevold et al 2004;Enomoto et al 2004). They form fenestrae to filter fluids, dissolved substances and particles from serum which are then adsorbed and metabolized by hepatocytes.…”
Section: Anatomy Of the Livermentioning
confidence: 99%