Cell–Cell Communication in Biofilms of Gram‐Negative Bacteria

Aguilar, Claudio; Carlier, Aurélien; Riedel, Kathrin; Eberl, Leo

doi:10.1002/9783527629237.ch2

Cited by 5 publications

(8 citation statements)

References 100 publications

(127 reference statements)

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“…It is well accepted that in natural settings bacteria are predominantly found adhered to surfaces, on which they develop into highly structured and architecturally complex communities by the production of an extracellular matrix (Aguilar et al 2009;Branda et al 2005;O'Toole et al 2000). This is the fundamental definition of a biofilm and, not surprisingly, bacterial biofilms represent an excellent setting for the study of multicellularity.…”

Section: Morphogenesis Of a Biofilm: Multicellularity In Actionmentioning

confidence: 98%

“…The exopolysaccharide component of the biofilm matrix has an important role for the biofilm community in addition to adhesion : in B. subtilis, it was proposed to generate osmotic pressure gradients that allow the cells to spread and find nutrients, making this process independent from motility (Seminara et al 2012). In addition, the exopolysaccharides play a critical role in initiating and maintaining the structure of the biofilm as well as conferring protection to adverse environmental conditions (Aguilar et al 2009). …”

Section: Living Inside the Matrix: Adhesive Components Of Biofilmsmentioning

confidence: 99%

“…Of these three, Pel and Psl are thought to be most important for biofilm structure under standard laboratory conditions. Although the third component, alginate, plays an important role in chronic lung infections of patients suffering from cystic fibrosis, it is only of very minor importance for biofilm formation on abiotic surfaces (Aguilar et al 2009). …”

Section: Living Inside the Matrix: Adhesive Components Of Biofilmsmentioning

confidence: 99%

“…Thus, it makes sense that the expression of at least some of the matrix components is tightly regulated. Cellto-cell communication, commonly referred to as quorum sensing (QS), is one of the mechanisms of genetic regulation that has emerged to play an important role in the establishment and development of bacterial biofilms (Aguilar et al 2009). QS systems in bacteria rely on the production, diffusion, detection and response to small signal molecules.…”

Section: The Role Of Chemical Signals In Biofilm Developmentmentioning

confidence: 99%

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Multicellularity in Bacteria: From Division of Labor to Biofilm Formation

Aguilar

Eichwald

Eberl

2015

Evolutionary Transitions to Multicellular Life

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Introduced nearly two decades ago, the concept of multicellularity in bacteria is currently accepted as a general trait of bacterial physiology. The view of bacteria being more than just unicellular, non-organized, selfish organisms is to a large degree based on the findings that division of labor and cell-to-cell communication within bacterial communities are ubiquitous across bacterial species. Bacteria are able to form complex communities in which cells can specialize in a spatiotemporal fashion, using extracellular signals to coordinate the expression of specific genes required for structural development. Despite the enormous progress made by researchers in the field over the past years, knowledge of the molecular mechanisms that govern bacterial multicellularity and biofilm development is scarce and remains a highly interesting field for future research.

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Section: Morphogenesis Of a Biofilm: Multicellularity In Actionmentioning

confidence: 98%

Section: Living Inside the Matrix: Adhesive Components Of Biofilmsmentioning

confidence: 99%

Section: Living Inside the Matrix: Adhesive Components Of Biofilmsmentioning

confidence: 99%

Section: The Role Of Chemical Signals In Biofilm Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Multicellularity in Bacteria: From Division of Labor to Biofilm Formation

Aguilar

Eichwald

Eberl

2015

Evolutionary Transitions to Multicellular Life

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“…Interestingly, the eDNA participates in the M. xanthus biofilm structural development by directly interacting with other polymers present in the matrix, namely the exopolysaccharides (Hu et al 2012). In addition, the exopolysaccharides play a critical role in initiating and maintaining the structure of the biofilm as well as conferring protection to adverse environmental conditions (Aguilar et al 2009). In addition, the exopolysaccharides play a critical role in initiating and maintaining the structure of the biofilm as well as conferring protection to adverse environmental conditions (Aguilar et al 2009).…”

Section: Living Inside the Matrix: Adhesive Components Of Biofilmsmentioning

confidence: 99%

Evolutionary Transitions to Multicellular Life

Sharpe¹,

Solé²,

Sebé-Pedrós³

et al. 2015

Advances in Marine Genomics

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This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made.Printed on acid-free paper Springer Netherlands is part of Springer Science+Business Media (www.springer.com) ForewordAs a young child growing up in Florida, I would set out on "treasure hunts" to look for fossils. The discovery of a Megalodon tooth or a mysterious fossilized bone would inspire thoughts about the lives of long-extinct creatures in a world before humans. And while my musings started with the fossils I could find and hold, with time I became curious about organisms and events from increasingly ancient times. How did tetrapods evolve? What about their ancestors, early aquatic vertebrates? How did developmental patterning evolve in the first bilaterians? And before that? What did the first animals look like? And from what did they evolve?How animals evolved from their single celled ancestors is one of the great mysteries in evolution and was likely set in motion by the origin of multicellularity. A remarkable process, one so striking that it is considered one of only eight "Major Transitions" in evolutionary history (Maynard Smith, John; Szathmáry, Eörs (1995). The Major Transitions in Evolution. Oxford, England: Oxford University Press. ISBN 0-19-850294-X), the transition to multicellularity occurred not just once, but repeatedly in diverse lineages. From relatively inconspicuous beginnings-sister cells that remained attached following division rather than going it alone-evolved the many multicellular life forms that fill our visible world today: brown algae, red algae, green algae, land plants, fungi, and animals.Despite the inherent interest surrounding the origins of multicellularity, relatively little is known about when, how, and why multicellularity evolved in each lineage. The potential barriers to reconstructing ancient transitions to multicellularity are diverse. For most multicellular lineages, the transition to multicellularity occurred hundreds of millions of years ago. The unicellular progenitors of...

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Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111

et al. 2012

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Burkholderia cenocepacia has emerged as an important pathogen for patients suffering from cystic fibrosis (CF). Previous work has shown that this organism employs the CepIR quorum-sensing (QS) system to control the expression of virulence factors as well as the formation of biofilms. To date, however, very little is known about the QS-regulated virulence factors and virtually nothing about the factors that link QS and biofilm formation. Here, we have employed a combined transcriptomic and proteomic approach to precisely define the QS regulon in our model strain B. cenocepacia H111, a CF isolate. Among the identified CepR-activated loci, three were analyzed in better detail for their roles in biofilm development: (i) a gene cluster coding for the BclACB lectins, (ii) the large surface protein BapA, and (iii) a type I pilus. The analysis of defined mutants revealed that BapA plays a major role in biofilm formation on abiotic surfaces while inactivation of the type I pilus showed little effect both in a static microtitre dish-based biofilm assay and in flow-through cells. Inactivation of the bclACB lectin genes resulted in biofilms containing hollow microcolonies, suggesting that the lectins are important for biofilm structural development.

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Cell–Cell Communication in Biofilms of Gram‐Negative Bacteria

Cited by 5 publications

References 100 publications

Multicellularity in Bacteria: From Division of Labor to Biofilm Formation

Multicellularity in Bacteria: From Division of Labor to Biofilm Formation

Evolutionary Transitions to Multicellular Life

Identification of functions linking quorum sensing with biofilm formation in Burkholderia cenocepacia H111

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