2011
DOI: 10.1007/s00018-011-0903-3
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Cell culture models and animal models for studying the patho-physiological role of renal aquaporins

Abstract: Aquaporins (AQPs) are key players regulating urinary-concentrating ability. To date, eight aquaporins have been characterized and localized along the nephron, namely, AQP1 located in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3 and AQP4 in collecting duct principal cells; AQP5 in intercalated cell type B; AQP6 in intercalated cells type A in the papilla; AQP7, AQP8 and AQP11 in the proximal tubule. AQP2, whose expression and cellular distribution is dependent on vasopressin st… Show more

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Cited by 26 publications
(21 citation statements)
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References 159 publications
(187 reference statements)
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“…In this way, high sodium diet favors urinary sodium concentration [9]. AQP2 has a role in hereditary and acquired diseases affecting urineconcentrating mechanisms [10]. AQP2 regulates antidiuretic action of arginine vasopressin (AVP).…”
Section: Aqp2mentioning
confidence: 99%
“…In this way, high sodium diet favors urinary sodium concentration [9]. AQP2 has a role in hereditary and acquired diseases affecting urineconcentrating mechanisms [10]. AQP2 regulates antidiuretic action of arginine vasopressin (AVP).…”
Section: Aqp2mentioning
confidence: 99%
“…Conversely, AQP4 null mice show only a mild deficit in urinary concentrating ability. In addition, AQP3/ AQP4 double-knockout mice show more severe polyuria than single AQP3 knockout mice (Ma et al, 2000;Tamma et al, 2012;Marlar et al, 2014), indicating the existence of a compensatory mechanism between AQP3 and AQP4 (Marlar et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…AQP2 is the main target of vasopressin (AVP), which regulates water permeability in the collecting duct (Nejsum et al, 2001;BonillaFelix, 2004). AVP regulates AQP2 via short-term and long-term regulatory mechanisms, which are fundamentally different (Nielsen and Agre, 1995;Poulsen et al, 2013) AQP2 null mice fail to thrive and die postnatally as a result of excessive extracellular fluid loss, indicating that the concentration of urine is dependent on the presence of AQP2 (Tamma et al, 2012;Xing et al, 2014). AQP3 and AQP4 are localized to the basolateral plasma membranes of principal cells in the connecting tubule and collecting duct (Murillo-Carretero et al, 1999;Nielsen et al, 1999;Tamma et al, 2012;Kortenoeven and Fenton, 2014) and provide potential pathways of water reabsorption via AQP2 (Wang et al, 2002;Nishimura and Yang, 2013;Koetenoeven and Fenton, 2014;Marlar et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
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