Cell-Cycle Checkpoints in a State Network

Lee, J. S.; Kahng, B.; Oh, Eunseon

doi:10.3938/jkps.52.193

Cited by 2 publications

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“…To address this, here we study the characteristics of fluctuations in the non-steady * Electronic address: kgoh@korea.ac.kr states, that of oscillatory systems in particular, by using a model genetic oscillatory system. Undoubtedly, oscillatory system is one of the most important systems that never reach steady states, which underlie a number of important cellular and physiological processes ranging from bacterial chemotaxis to mammalian circadian rhythms [8][9][10]. A number of synthetic gene circuits with a few components and relatively simple regulatory mechanisms have been constructed to realize oscillatory dynamics in protein numbers in vivo [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Noise Characteristics of Molecular Oscillations in Simple Genetic Oscillatory Systems

Min,

Goh,

Kim

2009

Preprint

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We study the noise characteristics of stochastic oscillations in protein number dynamics of simple genetic oscillatory systems. Using the three-component negative feedback transcription regulatory system called the repressilator as a prototypical example, we quantify the degree of fluctuations in oscillation periods and amplitudes, as well as the noise propagation along the regulatory cascade in the stable oscillation regime via dynamic Monte Carlo simulations. For the single protein-species level, the fluctuation in the oscillation amplitudes is found to be larger than that of the oscillation periods, the distributions of which are reasonably described by the Weibull distribution and the Gaussian tail, respectively. Correlations between successive periods and between successive amplitudes, respectively, are measured to assess the noise propagation properties, which are found to decay faster for the amplitude than for the period. The local fluctuation property is also studied.

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