1998
DOI: 10.1002/(sici)1097-4695(19980215)34:3<242::aid-neu4>3.0.co;2-2
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Cell death in the sexually dimorphic dorsal preoptic area/anterior hypothalamus of perinatal male and female ferrets

Abstract: A sexually dimorphic male nucleus (MN) is present in Nissl‐stained sections through the dorsal (d) preoptic area/anterior hypothalamus (POA/AH) of male ferrets. The MN‐POA/AH is composed of a cluster of large cells which is organized in males by the action of estradiol, formed via the neural aromatization of circulating testosterone (T), during the last quarter of a 41‐day gestation. Several recent studies using rodent species have raised the possibility that the hormone‐induced masculinization of POA/AH morph… Show more

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Cited by 16 publications
(9 citation statements)
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“…In rats where the SDN volume is 5-fold larger in males than in females, only ~1.5% of cells in this region are apoptotic during the neonatal critical period (Davis, Popper, and Gorski, 1996). Similarly low levels of apoptosis have been reported in other sexually dimorphic nuclei (Holman, Collado, Skepper, and Rice, 1996;Murakami and Arai, 1989;Park, Tobet, and Baum, 1998). The in vivo time course for elimination of apoptotic cells has been estimated to take about 72 h (Hu, Yuri, Ozawa, Lu, and Kawata, 1997), so it is possible that our sampling schedule is insufficiently comprehensive to capture the critical period for apoptosis in females.…”
Section: Discussionsupporting
confidence: 77%
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“…In rats where the SDN volume is 5-fold larger in males than in females, only ~1.5% of cells in this region are apoptotic during the neonatal critical period (Davis, Popper, and Gorski, 1996). Similarly low levels of apoptosis have been reported in other sexually dimorphic nuclei (Holman, Collado, Skepper, and Rice, 1996;Murakami and Arai, 1989;Park, Tobet, and Baum, 1998). The in vivo time course for elimination of apoptotic cells has been estimated to take about 72 h (Hu, Yuri, Ozawa, Lu, and Kawata, 1997), so it is possible that our sampling schedule is insufficiently comprehensive to capture the critical period for apoptosis in females.…”
Section: Discussionsupporting
confidence: 77%
“…In ferrets, a species like sheep in that a sexually dimorphic medial preoptic nucleus develops prior to birth (Cherry, Basham, Weaver, Krohmer, and Baum, 1990), Park et al (Park, Baum, Paredes, and Tobet, 1996;Park, Tobet, and Baum, 1998) found no sex difference in neurogenesis, migration or cell death and concluded that the specification of a distinctive neuronal phenotype i.e., soma size, area of dendritic fields or capacity to produce a specific molecule may be responsible for establishing volumetric sex differences in brain. The role of cell death and migration has also been challenged by recent studies in mice (Gilmore, Varnum, and Forger, 2012), which show that blocking bax-dependent developmental cell death through targeted deletion of the bax gene does not prevent sex differences from developing in the number of calbindin-immunoreactive neurons in the SDN.…”
Section: Discussionmentioning
confidence: 99%
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“…Lastly, it is possible that it is the survival of newborn neurons, rather than (or in addition to) their proliferation, that is sexually dimorphic, as has been previously demonstrated for prenatally generated hypothalamic neurons (Waters and Simerly 2009;Forger et al 2004;Tobet and Hanna 1997;Park et al 1998).…”
Section: Discussionmentioning
confidence: 99%
“…Male ferrets, for example, have more GAL-immunoreactive cells in the dorsal preoptic area/anterior hypothalamus than do females (Park et al, 1997). As there is no evidence for sex differences in neurogenesis, cell migration, or cell death in this area (Park et al, 1998), the sex difference in GAL expression may be based on sexual differentiation of neuronal phenotype as well.…”
Section: Discussionmentioning
confidence: 99%