Cell-Derived Microparticles/Exosomes in Neuroinflammation

Horstman, Lawrence L.; Jy, Wenche; Ahn, Yeon S.

doi:10.1007/978-3-319-51220-4_6

Cited by 2 publications

(1 citation statement)

References 146 publications

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“…The multifaceted functions of EVs in the nervous system are increasingly being studied [35][36][37][38], revealing that EVs are crucial mediators of processes such as inflammation [39,40], myelination [41,42] and neuron-glia communication [43,44]. In addition, several studies have reported the participation of EVs in myelination and demyelination [45].…”

Section: Introductionmentioning

confidence: 99%

The Role of Extracellular Vesicles in Demyelination of the Central Nervous System

López-Guerrero

Ripa

Andreu

et al. 2020

IJMS

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It is being increasingly demonstrated that extracellular vesicles (EVs) are deeply involved in the physiology of the central nervous system (CNS). Processes such as synaptic activity, neuron-glia communication, myelination and immune response are modulated by EVs. Likewise, these vesicles may participate in many pathological processes, both as triggers of disease or, on the contrary, as mechanisms of repair. EVs play relevant roles in neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases, in viral infections of the CNS and in demyelinating pathologies such as multiple sclerosis (MS). This review describes the involvement of these membrane vesicles in major demyelinating diseases, including MS, neuromyelitis optica, progressive multifocal leukoencephalopathy and demyelination associated to herpesviruses.

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Section: Introductionmentioning

confidence: 99%

The Role of Extracellular Vesicles in Demyelination of the Central Nervous System

López-Guerrero

Ripa

Andreu

et al. 2020

IJMS

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The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential

Najdaghi,

Davani,

Fouladseresht

et al. 2024

Cell Mol Neurobiol

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Microscopic, membranous vesicles known as extracellular vesicles (EVs) have been proposed to play a role in the mechanisms underlying central nervous system (CNS) diseases. EVs are secreted by a variety of cells, including myeloid, endothelial, microglial, oligodendroglial, and mesenchymal stem cells (MSCs). Body fluids such as plasma, urine, and cerebrospinal fluid (CSF) contain microparticles (MPs). The detection of MPs in CSF may indicate genetic or environmental susceptibility to conditions such as schizophrenia, schizoaffective disorder, and bipolar disorder. MPs of different origins can exhibit changes in specific biomarkers at various stages of the disease, aiding in the diagnosis and monitoring of neurological conditions. However, understanding the role and clinical applications of MPs is complicated by challenges such as their isolation and dual roles within the CNS. In this review, we discuss the history, characteristics, and roles of MPs in CNS diseases. We also provide practical insights for future research and highlight the challenges that obscure the therapeutic potential of MPs.

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Cell-Derived Microparticles/Exosomes in Neuroinflammation

Cited by 2 publications

References 146 publications

The Role of Extracellular Vesicles in Demyelination of the Central Nervous System

The Role of Extracellular Vesicles in Demyelination of the Central Nervous System

The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential

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