Cell division in the vomeronasal organ of the adult mouse

Barber, P. C.; Raisman, Geoffrey

doi:10.1016/0006-8993(78)90616-9

Cited by 131 publications

(76 citation statements)

References 16 publications

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“…In this study, mitotic figures were located in the boundaries as in other vertebrates (Graziadei, 1977;Barber and Raisman, 1978). However, in the mouse aged between 4 and 10 days, frequent mitoses were noted not only in the boundaries in the middle segment but also in the rostral segment of which entire lumen was covered with the ciliated columnar epithelium .…”

Section: Location Of Mitosessupporting

confidence: 47%

“…It has been described that the boundaries between the sensory epithelium lining the medial wall and the ciliated columnar epithelium covering the lateral wall of the middle segment are the regions of the vomeronasal organ in which mitoses persist during the first days of postnatal life (Graziadei, 1977;Barber and Raisman, 1978). In general, the regions where the 2 different types of epithelia adjoin are undifferentiated (Nakano, 1986).…”

Section: Location Of Mitosesmentioning

confidence: 99%

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Postnatal Transformation and Location of Mitoses in the Epithelium Lining the Mouse Vomeronasal Organ

Nakano

Hasegawa

Tomatsu

et al. 1990

Okajimas Folia Anatomica Japonica

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Section: Location Of Mitosessupporting

confidence: 47%

Section: Location Of Mitosesmentioning

confidence: 99%

Postnatal Transformation and Location of Mitoses in the Epithelium Lining the Mouse Vomeronasal Organ

Nakano

Hasegawa

Tomatsu

et al. 1990

Okajimas Folia Anatomica Japonica

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“…It is known that the vomeronasal projection is continuously renewed throughout life (Barber and Raisman, 1978;Gogos et al, 2000;Graziadei and Graziadei, 1979;Graziadei et al, 1978;Martinez-Marcos et al, 2000;Moulton, 1974). The expression of Robo2 and ephrin A5 on VNO axons of adult mice might reflect an involvement of these molecules in the guidance of later-forming axons.…”

Section: Potential Functions Of Robos In the Adult Vomeronasal Projecmentioning

confidence: 99%

On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion

et al. 2003

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The vomeronasal projection conveys information provided by pheromones and detected by neurones in the vomeronasal organ (VNO) to the accessory olfactory bulb (AOB) and thence to other regions of the brain such as the amygdala. The VNO-AOB projection is topographically organised such that axons from apical and basal parts of the VNO terminate in the anterior and posterior AOB respectively. We provide evidence that the Slit family of axon guidance molecules and their Robo receptors contribute to the topographic targeting of basal vomeronasal axons. Robo receptor expression is confined largely to basal VNO axons, while Slits are differentially expressed in the AOB with a higher concentration in the anterior part, which basal axons do not invade. Immunohistochemistry using a Robo-specific antibody reveals a zone-specific targeting of VNO axons in the AOB well before cell bodies of these neurones in the VNO acquire their final zonal position. In vitro assays show that Slit1-Slit3 chemorepel VNO axons, suggesting that basal axons are guided to the posterior AOB due to chemorepulsive activity of Slits in the anterior AOB. These data in combination with recently obtained other data suggest a model for the topographic targeting in the vomeronasal projection where ephrin-As and neuropilins guide apical VNO axons, while Robo/Slit interactions are important components in the targeting of basal VNO axons.

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“…VNO and OE neurons are both highly unusual among neurons in that they are short-lived and are replaced from a local stem cell population throughout life (10,11). In addition, both express olfactory marker protein (OMP) (12) and both are bipolar cells that extend fine processes (cilia or microvilli) into the external environment and project axons to the olfactory bulb of the brain (1,6,11).…”

Section: Introductionmentioning

confidence: 99%

Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs.

Berghard

Buck

Liman

1996

Proc. Natl. Acad. Sci. U.S.A.

132

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In mammals, olfactory stimuli are detected by sensory neurons at two distinct sites: the olfactory epithelium (OE) of the nasal cavity and the neuroepithelium of the vomeronasal organ (VNO). While the OE can detect volatile chemicals released from numerous sources, the VNO appears to be specialized to detect pheromones that are emitted by other animals and that convey information of behavioral or physiological importance. The Communication among mammals via chemical messengers known as pheromones may play important roles in a variety of social interactions, especially those associated with reproduction (1-4). Pheromones present in urine or vaginal secretions have been implicated in such effects as the initiation of copulatory behavior in male hamsters and alterations in reproductive state in mice, including acceleration or suppression of puberty and block of pregnancy. The accessory olfactory system, which originates in the sensory neuroepithelium of the vomeronasal organ (VNO), is thought to be specialized to detect pheromones (1-4).In rodents, the VNO is a cartilage-encased tubular structure, which is located at the base of the nasal septum and opens into the nasal cavity via a single duct. Molecules dissolved in nasal mucus are pumped into the VNO lumen by changes in VNO blood volume (5). Like the olfactory epithelium (OE) of the nasal cavity, which detects volatile odorants as well as some pheromones, the VNO neuroepithelium contains sensory neurons that project axons to the olfactory bulb of the brain. However, the pathways followed by sensory information that enters the olfactory system through the VNO and OE, the "accessory" and "main" olfactory pathways, respectively, are distinct and remain separate at all levels of the nervous system (6). OE-derived signals ultimately reach multiple brain regions, including the frontal cortex, which is thought to mediate the conscious perception of odors. In contrast, VNO-derivedThe publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact. signals are targeted to hypothalamic structures implicated in reproductive physiology and behavior (7,8).The neuroepithelium of the VNO is derived embryologically as an evagination from the developing OE and resembles the OE morphologically (9). VNO and OE neurons are both highly unusual among neurons in that they are short-lived and are replaced from a local stem cell population throughout life (10, 11). In addition, both express olfactory marker protein (OMP) (12) and both are bipolar cells that extend fine processes (cilia or microvilli) into the external environment and project axons to the olfactory bulb of the brain (1, 6, 11). These similarities have suggested that neurons in the OE and VNO might use the same mechanisms, perhaps even the same molecules, to transduce sensory stimuli.Very little is known about sensory transduction in the VNO. However, extensive studies of s...

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Cell division in the vomeronasal organ of the adult mouse

Cited by 131 publications

References 16 publications

Postnatal Transformation and Location of Mitoses in the Epithelium Lining the Mouse Vomeronasal Organ

Postnatal Transformation and Location of Mitoses in the Epithelium Lining the Mouse Vomeronasal Organ

On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion

Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs.

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