Cell-drug-cell ternary interactions. Effect of some antiaggreggant drugs on ESR

Voicu, Victor; Mircioiu, Constantin; Jiquidi, M.

doi:10.1016/1043-6618(95)87603-0

Cited by 2 publications

(5 citation statements)

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“…Hence, chlorpheniramine (CLF), although not presenting intrinsic analgesic effect (Rumore and Schlichting, 1986; Raffa, 2001), significantly potentiates both the anti-inflammatory and analgesic effect of the ASA–PAR–CAF combination. This strong potentiation effect was underlined in our previous studies both in vitro , in analgesia and carrageenan-induced rat paw inflammation models, as well as in vivo in the treatment of mild algic syndrome (Voicu et al, 2016).…”

Section: Introductionsupporting

confidence: 60%

“…Taking into account all the above considerations, for the assessment of the clinical significance of the analgesic effect for the ASA–PAR–CAF–CLF combination, we considered the best comparator to be the standard analgesic clinical treatment for LBP, i.e., PAR. In fact, in one of our previous experiments (Voicu et al, 2016), the effect of ALG was found to be significantly superior to both ASA and CLF, as evaluated on a carrageenan-induced rat paw model of inflammation, and their further use as comparators in the present study is not being considered justified.…”

Section: Discussionmentioning

confidence: 58%

“…The subsequent researches focused on evaluation of the ASA–PAR–CAF–CLF low-dose combination in the treatment of migraine. Thus, clinical studies (Blendea et al, 2011; Enache et al, 2012) proved the noninferiority of a unique dose of Algopirin ® (ALG), an authorized combination of the four active containing 125 mg ASA, 75 mg PAR, 15 mg CAF, and 2 mg CLF (Voicu et al, 2016; Voicu et al, 2017a) vs. Excedrin ® , a fixed combination drug containing 250 mg ASA, 250 mg PAR, and 65 mg CAF. The extension study (Voicu et al, 2017b) also proved the superiority of two tablets of ALG vs. one tablet of Excedrin ® , though the doses of active components in the ALG treatment remained lower than in the case of Excedrin ® .…”

Section: Introductionmentioning

confidence: 99%

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Effect of a New Synergistic Combination of Low Doses of Acetylsalicylic Acid, Caffeine, Acetaminophen, and Chlorpheniramine in Acute Low Back Pain

Voicu

Mircioiu

Pleşa³

et al. 2019

Front. Pharmacol.

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The present paper continues a more complex research related to the increased synergism in terms of both anti-inflammatory and analgesic effect obtained by the addition of chlorpheniramine (CLF) to the common acetylsalicylic acid (ASA), acetaminophen (PAR), and caffeine (CAF) combination. This synergistic effect was previously highlighted both in vitro in rat models and in vivo in the treatment of migraine. The aim of the research was to further evaluate the analgesic effect of a synergistic low-dose ASA–PAR–CAF–CLF combination in the treatment of low back pain, in a parallel, multiple-dose, double-blind, active controlled clinical trial. A number of 89 patients with low back pain of at least moderate intensity were randomly assigned to receive Algopirin ® (ALG), a combinational product containing 125 mg ASA, 75 mg PAR, 15 mg CAF, and 2 mg CLF, or PAR 500 mg, a drug recognized by American Pain Society as “safe and effective” in the treatment of low back pain. One tablet of the assigned product was administered three times a day for seven consecutive days. The patients evaluated their pain level using a Visual Analog Scale prior to administration, and at 1, 2, 4, and 6 h after the morning dose. Time course of effect was similar in structure and size for both treatments. Pain relief appeared rapidly and steadily increased over 4 h after drug administration. Differential pain curves of ALG and PAR were very similar and comparable with the previously determined ALG analgesia pattern in migraine. Differences between the daily mean pain scores were not statistically significant for the two treatments. Similar results were obtained for the Sum of Pain Intensity Differences (SPID) for 0–4 h and 0–6 h intervals as well as for the time course of the proportion of patients with at least 30% and at least 50% pain relief. In conclusion, in spite of very small doses of active components, ALG proved equally effective to the standard low back pain treatment and therefore a viable therapeutic alternative, mainly for patients with gastrointestinal and hepatic sensitivity. Trial Registration: , identifier EudraCT No.: 2015–002314–74.

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Section: Introductionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

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Effect of a New Synergistic Combination of Low Doses of Acetylsalicylic Acid, Caffeine, Acetaminophen, and Chlorpheniramine in Acute Low Back Pain

Voicu

Mircioiu

Pleşa³

et al. 2019

Front. Pharmacol.

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“…Although CLF does not have antiinflammatory or analgesic effects, our studies highlighted, using the rat paw model and a clinical study a supplementary potentiation of the both anti-inflammatory (Voicu et al, 2016) and analgesic effect (Blendea et al, 2011) of the overall combination following its addition to ASA-PAR-CAF.…”

Section: Introductionmentioning

confidence: 77%

“…A clinical study (Blendea et al, 2011; Enache et al, 2012) highlighted the non-inferiority of a unique dose of Algopirin®, product based on a new analgesic combination (Voicu et al, 2016) containing 125 mg ASA + 75 mg PAR + 15 mg CAF + 2 mg CLF vs. Excedrin®, a fixed combination drug containing 250 mg ASA + 250 mg PAR + 65 mg CAF. The effect was installed some 10–15 min more rapid in case of Excedrin® but the extent was approximately similar for the two combinations.…”

Section: Introductionmentioning

confidence: 99%

Chlorpheniramine Potentiates the Analgesic Effect in Migraine of Usual Caffeine, Acetaminophen, and Acetylsalicylic Acid Combination

et al. 2017

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Previous studies indicated that addition of the antihistaminic chlorpheniramine to the usual combination of acetylsalicylic acid, acetaminophen, and caffeine further increases their synergism both in terms of anti-inflammatory and analgesic effect. The present non-interventional study tested the superiority of two Algopirin® tablets, containing a total of 250 mg acetylsalicylic acid (ASA), 150 mg acetaminophen (paracetamol, PAR), 30 mg caffeine (CAF) and 4 mg chlorpheniramine (CLF) vs. a combination containing 250 mg ASA, 250 mg PAR, and 65 mg CAF recognized as “safe and effective” by FDA in treating migraine. Patients evaluated their pain intensity on the Visual Analog Scale—VAS(PI) before and 30, 60, 120, 180, and 240 min after drug intake. Interpretation of the pain curves as “survival pain curves” was considered as a method for direct comparison of the pain curves. This interpretation permitted the application of the log rank test for comparison of pain hazards. The results of the applied parametric and non-parametric statistical tests indicated significant differences between the main endpoints: both Areas Under Pain Curves and time to decrease of the pain intensity to less than 50% of the initial value comparisons highlighted that Algopirin® was more efficient in spite of smaller doses of PAR and CAF. Comparison of “survival of pain” led to the same conclusion concerning the superiority of Algopririn. Consequently, the addition of CLF permitted decreasing of ASA, PAR, and CAF doses as well as their potential side effects, without a loss of analgesic effect.

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Cell-drug-cell ternary interactions. Effect of some antiaggreggant drugs on ESR

Cited by 2 publications

References 0 publications

Effect of a New Synergistic Combination of Low Doses of Acetylsalicylic Acid, Caffeine, Acetaminophen, and Chlorpheniramine in Acute Low Back Pain

Effect of a New Synergistic Combination of Low Doses of Acetylsalicylic Acid, Caffeine, Acetaminophen, and Chlorpheniramine in Acute Low Back Pain

Chlorpheniramine Potentiates the Analgesic Effect in Migraine of Usual Caffeine, Acetaminophen, and Acetylsalicylic Acid Combination

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