Cell Dynamics of the Ovarian Cycle

Peters, Hannah; Levy, Emilia

doi:10.1530/jrf.0.0110227

Cited by 44 publications

(11 citation statements)

References 2 publications

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“…The observation that FSH stimulated the development of antral follicles is in agreement with the work of Hirshfield & Midgley (1978) Although these studies do not completely eliminate the possibility that LH has a permissive effect, they suggest that, in mice at least, an increase in the plasma LH concentration, on its own, is not sufficient to stimulate antral follicle development, and FSH is also required for this process, as was suggested by Lostroh & Johnson (1966 In normal mice the size of the interstitial compartment increases with increasing age and this has been attributed to the formation of interstitial cells from follicular cells, largely by the trans¬ formation of thecal cells (Peters & Levy, 1966). They possess LH receptors (Charlton et al, 1982) and resemble typical steroid-secreting cells (Mutta, 1958;Fawcett et al, 1969).…”

Section: Discussionmentioning

confidence: 94%

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Halpin¹,

Charlton²

1988

Reproduction

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Section: Discussionmentioning

confidence: 94%

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Halpin¹,

Charlton²

1988

Reproduction

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“…In immature and adult rodent ovaries, such cell nests do not occur and no evidence of germ cell proliferation has been reported (Rudkin & Griech 1962, Peters & Levy 1966, Peters & Crone 1967, Hoage & Cameron 1976, suggesting that oogenesis in some species of prosimian primates is an isolated phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply

Kerr¹,

Duckett²,

Myers³

et al. 2006

Reproduction

195

180

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Proliferation and partial meiotic maturation of germ cells in fetal ovaries is believed to establish a finite, non-renewable pool of primordial follicles at birth. The supply of primordial follicles in postnatal life should be depleted during folliculogenesis, either undergoing atresia or surviving to ovulation. Recent studies of mouse ovaries propose that intra-and extraovarian germline stem cells replenish oocytes and form new primordial follicles. We quantified all healthy follicles in C57BL/6 mouse ovaries from day 1 to 200 using unbiased stereological methods, immunolabelling of oocyte meiosis (germ cell nuclear antigen (GCNA)) and ovarian cell proliferation (proliferating cell nuclear antigen (PCNA)) and electronmicroscopy. Day 1 ovaries contained 7924G1564 (S.E.M.) oocytes or primordial follicles, declining on day 7 to 1987G203, with 200-800 oocytes ejected from individual ovaries on that day and day 12. Discarded oocytes and those subjacent to the surface epithelium were GCNA-positive indicating their incomplete meiotic maturation. From day 7 to 100 mean numbers of primordial follicles per ovary were not significantly depleted but declined at 200 days to 254G71. Mean numbers of all healthy follicles per ovary were not significantly different from day 7 to 100 (range 2332G349-3007G322). Primordial follicle oocytes were PCNA-negative. Occasional unidentified cells were PCNA-positive with mitotic figures observed in the cortex of day 1 and 12 ovaries. Although we found no evidence for ovarian germline stem cells, our data support the hypothesis of postnatal follicle renewal in postnatal and adult ovaries of C57BL/6 mice. Reproduction (2006) 132 95-109

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“…In recent years, oocytes have been utilized for purposes such as research in the field of human reproductive medicine and studies on regenerative medicine using embryonic stem (ES) cells derived from cloned blastocysts [2,3]. However, only a limited number of oocytes grow completely and acquire competency because a species-specific number of follicles is selected from a large pool of primordial follicles for entry into the growth phase in vivo [4][5][6][7][8]. Therefore, there is an imminent critical shortage of oocytes.…”

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confidence: 99%

Long-Term Effects of In Vitro Growth of Mouse Oocytes on Their Maturation and Development

et al. 2007

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Abstract. Since very few oocytes grow completely in vivo, in vitro growth (IVG) of ovarian oocytes may provide a new source of functional oocytes. The long-term effects of in vitro maturation (IVM) of oocytes and in vitro culture of fertilized eggs have been reported; however, the effects of IVG of oocytes are unknown. Here in, we report the long-term effects of IVG of oocytes. Ovaries from 1-dayold mice containing non-growing oocytes were cultured for 10 days; the isolated follicles were then cultured for 11 days. Secondary follicles from 10-day-old mice were also cultured for 11 days. The nuclei of oocytes collected from the IVG and Graafiais follicles of adult mice were transferred to enucleated oocytes grown in vivo, respectively. Developmental competence was examined following IVM of the reconstituted oocytes. Chronologically, oocytes of 1-day-old, 10-day-old and adult mice were cultured for 22, 12 and 1 day(s). The result showed that the reconstituted eggs developed into pups at high rates after nuclear transfer and in vitro fertilization (IVF) in all the experimental groups (29-45%). However, the pups from reconstituted eggs containing the nuclei of 22-day cultured oocytes were heavier than the control pups (P<0.05). We concluded that long-term culture of oocytes did not affect their nuclear ability to develop to term; however, fetal growth was affected by the culture duration or culture conditions during the initial phase of follicular growth.

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Cell Dynamics of the Ovarian Cycle

Cited by 44 publications

References 2 publications

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice

Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply

Long-Term Effects of In Vitro Growth of Mouse Oocytes on Their Maturation and Development

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