Cell fusion through slime mould network dynamics

Hsu, Sheryl; Schaposnik, Laura P.

doi:10.1098/rsif.2022.0054

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…The cellular growth strategy during the plasmodial phase is notably intriguing. Beyond growth via synchronous nuclear division occurring in consistent cycles [4], plasmodia also employ a fusion strategy with other individuals of the same species [9, 10, 11]. This phenomenon has been reported in the genera Physarum and Didymium [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Myxomycetes have an allorecognition system that can only discriminate between intraspecies

Masui,

Yamamoto,

Kono

2024

Preprint

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Myxomycetes are multinucleate unicellular organisms. They form a plasmodium that moves by protoplasmic flow and prey on microorganisms. When encountering intraspecifics, the plasmodium has the capacity for "fusion", actively approaching and fusing its cells, or "avoidance", altering its direction to avoid the other individual. This is an allorecognition ability. However, it remains unclear whether the range of allorecognition extends to other species, and its ecological significance is also obscure. Here, we conduct a quantitative evaluation of contact responses from closely related species of plasmodium to clarify the recognition range of the allorecognition system in Myxomycetes. Behavioral assays demonstrate that the allorecognition system recognizes individuals within the same species while failing to recognize those of different species. The allorecognition is an extremely narrow and inward-focused mechanism, arguing for a highly specialized system of self-other recognition.

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Section: Introductionmentioning

confidence: 99%

Myxomycetes have an allorecognition system that can only discriminate between intraspecies

Masui,

Yamamoto,

Kono

2024

Preprint

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A Physarum-inspired approach to the Euclidean Steiner tree problem

Hsu

Massolo

Schaposnik

2022

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This paper presents a novel biologically-inspired explore-and-fuse approach to solving a large array of problems. The inspiration comes from Physarum, a unicellular slime mold capable of solving the traveling salesman and Steiner tree problems. Besides exhibiting individual intelligence, Physarum can also share information with other Physarum organisms through fusion. These characteristics of Physarum imply that spawning many such organisms we can explore the problem space in parallel, each individual gathering information and forming partial solutions pertaining to a local region of the problem space. When the organisms meet, they fuse and share information, eventually forming one organism which has a global view of the problem and can apply its intelligence to find an overall solution to the problem. This approach can be seen as a “softer” method of divide and conquer. We demonstrate this novel approach, developing the Physarum Steiner Algorithm which is capable of finding feasible solutions to the Euclidean Steiner tree problem. This algorithm is of particular interest due to its resemblance to Physarum polycephalum, ability to leverage parallel processing, avoid obstacles, and operate on various shapes and topological surfaces including the rectilinear grid.

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Cell fusion through slime mould network dynamics

Hsu

Schaposnik

2022

J. R. Soc. Interface.

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Physarum polycephalum is a unicellular slime mould that has been intensely studied owing to its ability to solve mazes, find shortest paths, generate Steiner trees, share knowledge and remember past events and the implied applications to unconventional computing. The CELL model is a cellular automaton introduced in Gunji et al . (Gunji et al. 2008 J. Theor. Biol. 253 , 659–667 ( doi:10.1016/j.jtbi.2008.04.017 )) that models Physarum ’s amoeboid motion, tentacle formation, maze solving and network creation. In the present paper, we extend the CELL model by spawning multiple CELLs, allowing us to understand the interactions between multiple cells and, in particular, their mobility, merge speed and cytoplasm mixing. We conclude the paper with some notes about applications of our work to modelling the rise of present-day civilization from the early nomadic humans and the spread of trends and information around the world. Our study of the interactions of this unicellular organism should further the understanding of how P. polycephalum communicates and shares information.

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Cell fusion through slime mould network dynamics

Cited by 4 publications

References 27 publications

Myxomycetes have an allorecognition system that can only discriminate between intraspecies

Myxomycetes have an allorecognition system that can only discriminate between intraspecies

A Physarum-inspired approach to the Euclidean Steiner tree problem

Cell fusion through slime mould network dynamics

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