Cell-Intrinsic Differences between Stem Cells from Different Regions of the Peripheral Nervous System Regulate the Generation of Neural Diversity

Bixby, Suzanne; Kruger, Genevieve M.; Mosher, Jack T.; Joseph, Nancy M.; Morrison, Sean J.

doi:10.1016/s0896-6273(02)00825-5

Cited by 278 publications

(265 citation statements)

References 66 publications

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“…Postmigratory NCSCs isolated from neurogenic structures, such as the enteric nervous system, exhibit extensive selfrenewal capacity and can be readily passaged in sphere cultures [27]. To determine the self-renewal potential of PAderived mesenchymal progenitor cells, single cells were cultured in sphere medium permissive for self-renewal of NCSCs [28].…”

Section: Identification and Characterization Of Nc-derived Mesenchymamentioning

confidence: 99%

Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells

et al. 2011

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During vertebrate development, neural crest stem cells (NCSCs) give rise to neural cells of the peripheral nervous system and to a variety of mesenchymal cell types, including smooth muscle, craniofacial chondrocytes, and osteocytes. Consistently, mesenchymal stem cells (MSCs) have recently been shown to derive in part from the neural crest (NC), although the mechanisms underlying MSC generation remains to be identified. Here, we show that transforming growth factor b (TGFb)-mediated suppression of the NCSC transcription factor Sox10 induces a switch in neural to mesenchymal potential in NCSCs. In vitro and in vivo, TGFb signal inactivation results in persistent Sox10 expression, decreased cell cycle exit, and perturbed generation of mesenchymal derivatives, which eventually leads to defective morphogenesis. In contrast, TGFb-mediated downregulation of Sox10 or its genetic inactivation suppresses neural potential, confers mesenchymal potential to NC cells in vitro, and promotes cell cycle exit and precocious mesenchymal differentiation in vivo. Thus, negative regulation of Sox10 by TGFb signaling promotes the generation of mesenchymal progenitors from NCSCs. Our study might lay the grounds for future applications demanding defined populations of MSCs for regenerative medicine. STEM CELLS 2011;29:689-699 Disclosure of potential conflicts of interest is found at the end of this article.

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Section: Identification and Characterization Of Nc-derived Mesenchymamentioning

confidence: 99%

Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells

et al. 2011

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“…This paradigm was first established in the haematopoietic system in mice and humans and has since been extended to many other tissues in both species 3 . Interestingly, it has also become apparent that even stringently defined normal tissue stem cells with extensive self-renewal properties can be intrinsically heterogeneous with regard to their differentiation and selfrenewal control in different sites or stages of development [19][20][21] . Thus, heterogeneity among CSCs in a single tumour type, or even within a single tumour, cannot be assumed to be indicative of an abnormal (tumour-specific) process or to be a consequence of a DNA mutation.…”

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confidence: 99%

Cancer stem cell definitions and terminology: the devil is in the details

Valent

Bonnet

Maria³

et al. 2012

Nat Rev Cancer

625

564

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| The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients. PERSPECTIVES NATURE REVIEWS | CANCER VOLUME 12 | NOVEMBER 2012 | 767

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“…CSCs are a small population present in cancer cells with unique properties: i) self-renewal capability, ii) cell differentiation ability and iii) cancer initiation potential (33,34). These properties of CSCs contribute to chemoradiotherapy resistance and cause tumor recurrence.…”

Section: The Resistance Mechanisms Of Cscsmentioning

confidence: 99%

Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review)

et al. 2015

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Abstract. Cancer stem cells (CSCs) are a small population of cells in cancer with stem-like properties such as cell proliferation, multiple differentiation and tumor initiation capacities. CSCs are therapy-resistant and cause cancer metastasis and recurrence. One key issue in cancer therapy is how to target and eliminate CSCs, in order to cure cancer completely without relapse and metastasis. To target CSCs, many cell surface markers, DNAs and microRNAs are considered as CSC markers. To date, the majority of the reported markers are not very specific to CSCs and are also present in nonCSCs. However, the combination of several markers is quite valuable for identifying and targeting CSCs, although more specific identification methods are needed. While CSCs are considered as critical therapeutic targets, useful treatment methods remain to be established. Epigenetic gene regulators, microRNAs, are associated with tumor initiation and progression. MicroRNAs have been recently considered as promising therapeutic targets, which can alter the therapeutic resistance of CSCs through epigenetic modification. Moreover, carbon ion beam radiotherapy is a promising treatment for CSCs. Evidence indicates that the carbon ion beam is more effective against CSCs than the conventional X-ray beam. Combination therapies of radiosensitizing microRNAs and carbon ion beam radiotherapy may be a promising cancer strategy. This review focuses on the identification and treatment resistance of CSCs and the potential of microRNAs as new radiosensitizers and carbon ion beam radiotherapy as a promising therapeutic strategy against CSCs.

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Cell-Intrinsic Differences between Stem Cells from Different Regions of the Peripheral Nervous System Regulate the Generation of Neural Diversity

Cited by 278 publications

References 66 publications

Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells

Transforming Growth Factor β-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells

Cancer stem cell definitions and terminology: the devil is in the details

Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review)

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