Cell-Kill Modeling of Microwave Thermotherapy for Treatment of Benign Prostatic Hyperplasia

Bolmsjö, Magnus; Schelin, Sonny; Wagrell, Lennart; Larson, Thayne R.; Rosette, Jean J.M.C.H. de la; Mattiasson, Anders

doi:10.1089/end.2000.14.627

Cited by 30 publications

(15 citation statements)

References 22 publications

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“…The treatment catheters used contain a probe with multiple inline sensors that extend into the prostate to monitor intraprostatic temperature. This allows realtime monitoring of the treatment, together with an approximate calculation of the volume of tissue coagulation (cell-kill parameter) [8]. During the treatment the urologist can adjust the power of the device and thus maintain the intraprostatic temperature at an optimal level to create the desired amount of necrosis.…”

Section: Methodsmentioning

confidence: 99%

Transurethral microwave thermotherapy of the prostate – Evaluation with MRI and analysis of parameters relevant to outcome

Veselý

Müller

Knutson

et al. 2008

Scandinavian Journal of Urology and Nephrology

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Section: Methodsmentioning

confidence: 99%

Transurethral microwave thermotherapy of the prostate – Evaluation with MRI and analysis of parameters relevant to outcome

Veselý

Müller

Knutson

et al. 2008

Scandinavian Journal of Urology and Nephrology

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“…As described by Bolmsjo et al [14], transurethral thermotherapy is similar to any burn injury in that an intense inflammatory reaction is produced, leading to rapid necrosis and edema. Upon initial insult, the necrotic zone is sharply demarcated, histologically, from the surrounding tissue.…”

Section: Historic Perspectivementioning

confidence: 97%

“…HE-TUMT is able to generate massive cell-kill in shorter duration. Cell-kill modeling was described by Bolmsjo et al [14] and is a measurable entity that directly correlates with tissue coagulation. The CoreTherm feedback treatment quantifies cell-kill realtime during therapy, thus enabling the urologist to assess progression and determine the duration of the treatment.…”

Section: Historic Perspectivementioning

confidence: 99%

Long-term treatment outcomes of CoreTherm microwave feedback thermotherapy

Eisenberg

Badlani²

2004

Curr Urol Rep

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The gold standard for definitive management of symptomatic benign prostatic hypertrophy is transurethral resection of the prostate (TURP). Despite its efficacy, TURP has significant morbidity/mortality concerns such as hemorrhage and transurethral resection syndrome. This is especially worrisome for the medically high-risk patient, but the high rates of retrograde ejaculation found with TURP also pose a problem for young patients. A minimally invasive, outpatient alternative to TURP that has long-term efficacy, low morbidity/mortality, and provides a cost-effective advantage is in high demand. This review article discusses microwave thermotherapy as such an option and reports the long-term experience with the CoreTherm (CoreTherm Operations AB, Sweden) device.

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“…During the first phase (typically lasting 10 to 30 minutes), the blood flow to the area often doubles, with no significant cell destruction. However, during the second phase blood flow decreases, which is most likely due to localized microthrombosis in the hottest places in the tissue, and the amount of tissue necrosis increases significantly [2]. Reversible thermal effects have been shown to occur when tumors are briefly heated up to 44 • C and then allowed to cool.…”

Section: Basic Hyperthermia Treatmentsmentioning

confidence: 99%

Using Microwave Energy to Treat Tumors

Ibrahim¹

2008

PIER B

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Abstract-Recently, hyperthermia has been investigated as an alternate therapy for the treatment of tumors. This paper explored the feasibility of preferential hyperthermia as a method of treating deep seated tumors. The overall goal of this research was to determine theoretically if preferential heating could be used to attain the desired thermal dose (DTD) for a two cm diameter tumor. The simulations in this work show that, when using a single rod insert, the model cannot provide enough energy for an entire 2 cm diameter tumor to receive the DTD. However, when using an enhanced design model with multiple (4) rods inserts, the DTD could be attained in a tumor up to 3.5 cm in diameter. This study involved using the model a spherical 2 cm tumor, assuming the tumor is located in deep tissue with a constant perfusion rate and no major blood vessels nearby. This tumor was placed in the center of a cube of healthy tissue. To achieve the preferential heating of the tumor, a rod insert was placed in the center of the tumor and microwave energy was applied to the insert (in the form of volumetric heating). The thermal modeling of this system was based on the Pennes Bioheat equation with a maximum temperature limitation of 80 • C. Additional enhanced design models were also examined. These models include 2 cm and 4 cm tumors with four rod inserts symmetrically placed about the tumor and a 4 cm tumor model using a single rod insert with antennae attached to insert to increase energy distribution to the tumor. The simulations show that only the enhanced design cases with four rods inserts can achieve the DTD for an entire 2 cm tumor. The main purpose of this research was to determine if a minimally invasive treatment system using one or more rod inserts could be used to preferentially heat (and attain the DTD) a 2 cm diameter (or larger) tumor. Achieving the DTD for a 2 cm or larger tumor was important because currently the maximum diameter tumor that can be treated via hyperthermia is approximately

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Cell-Kill Modeling of Microwave Thermotherapy for Treatment of Benign Prostatic Hyperplasia

Cited by 30 publications

References 22 publications

Transurethral microwave thermotherapy of the prostate – Evaluation with MRI and analysis of parameters relevant to outcome

Transurethral microwave thermotherapy of the prostate – Evaluation with MRI and analysis of parameters relevant to outcome

Long-term treatment outcomes of CoreTherm microwave feedback thermotherapy

Using Microwave Energy to Treat Tumors

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