1978
DOI: 10.1073/pnas.75.1.376
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Cell lineages of the embryo of the nematode Caenorhabditis elegans.

Abstract: Embryogenesis of the free-living soil nematodeCaenorhabditis elegans produces a juvenile having about 550 cells at hatching. We have determined the lineages of 182 cells by tracing the divisions of individual cells in living embryos. An invariant pattern of cleavage divisions of the egg generates a set of stem cells. These stem cells are the founders of six stem cell lineages. Each lineage has its own clock-i.e., an autonomous rhythm of synchronous cell divisions. The rhythms are maintained in spite of extensi… Show more

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Cited by 270 publications
(163 citation statements)
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“…The intestine is not only responsible for assimilation and digestion of food but also for synthesis and storage of macromolecules such as yolk proteins [McGhee, 2007]. A single cell, the E-blastomere of the eight-cell embryo, gives rise to the entire intestine [Deppe et al, 1978;Sulston et al, 1983;Leung et al, 1999]. The E-cell divides in a stereotypic pattern leading to a defined arrangement of the resulting 20 cells which encircle the intestinal lumen as a series of nine rings referred to as ''ints'' [ Fig.…”
Section: Intermediate Filaments In the C Elegans Intestinementioning
confidence: 99%
“…The intestine is not only responsible for assimilation and digestion of food but also for synthesis and storage of macromolecules such as yolk proteins [McGhee, 2007]. A single cell, the E-blastomere of the eight-cell embryo, gives rise to the entire intestine [Deppe et al, 1978;Sulston et al, 1983;Leung et al, 1999]. The E-cell divides in a stereotypic pattern leading to a defined arrangement of the resulting 20 cells which encircle the intestinal lumen as a series of nine rings referred to as ''ints'' [ Fig.…”
Section: Intermediate Filaments In the C Elegans Intestinementioning
confidence: 99%
“…Caenorhabditis elegans was the first to benefit from comprehensive time-lapse imaging at a spatiotemporal resolution sufficient to trace all cells and cell divisions during development, using non-fluorescent differential interference contrast optics [4,5]. This allows an alternative approach for determining the lineage of cells -retrospective lineage analysis.…”
Section: Biophotonicsmentioning
confidence: 99%
“…1; Deppe et al 1978;Sulston et al 1983). Each of the founder cells shows distinct rates of cell division and produces a unique repertoire of differentiated cell types.…”
mentioning
confidence: 99%