Cell‐mediated immune response: a clinical review of the therapeutic potential of human papillomavirus vaccination

Meyer, Sonja; Fuglsang, Katrine; Blaakær, Jan

doi:10.1111/aogs.12480

Cited by 14 publications

(7 citation statements)

References 17 publications

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“…The results reinforce previous studies (4,7,13,14) that show an increase in immune cell activity following vaccination. There is evidence that CMI responses play an important role in the control of HPV infections.…”

Section: Discussionsupporting

confidence: 92%

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Human Papillomavirus Vaccine-Induced Cytokine Messenger RNA Expression in Vaccinated Women

et al. 2015

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The objective of this work was to evaluate the influence of human papillomavirus (HPV) vaccination on peripheral blood mononuclear cell (PBMC) proliferation and cytokine gene transcription. PBMCs isolated after HPV immunization were incubated with HPV vaccine, phytohemagglutinin, or buffer. Cell proliferation was assessed by MTT reduction assay. RNA was extracted from PBMCs, and the relative concentration of cytokine messenger RNA (mRNA) transcripts (IFN-β, IFN-γ, IL-12, TNF-α, IL-6, IL-17, or IL-10) relative to transcription of the β-actin gene was determined by real-time polymerase chain reaction. PBMC proliferation in response to HPV vaccine and PHA were greater than that observed in unstimulated cells (p<0.001). Cytokine mRNAs were upregulated in stimulated PBMC cultures. The median increase in vaccine-stimulated cultures was: IFN-β=334.4-fold; IL-12=46.33-fold; IFN-γ=12.64-fold; IL-6=9.07-fold; IL-17=7.33-fold; IL-10=6.47-fold; and TNF-α=2.36-fold. The IFN-β expression was significantly higher (p<0.05). Proliferative PBMC responses and multiple cytokine gene expression were detected in women who received the HPV vaccine.

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Section: Discussionsupporting

confidence: 92%

“…Previous studies found that a significant cellular mediated immune (CMI) response is induced following HPV vaccination (4,7,13,14).…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Vaccine-Induced Cytokine Messenger RNA Expression in Vaccinated Women

et al. 2015

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“…Catch-up vaccination using the standard dosing intervals is also recommended for females and males aged 13 through 26 years old if they were not previously vaccinated or if they have not completed the three-dose series (122). Vaccination in the general population induces a cell-mediated immune response and a strong humoral immune response with antibody titers several times higher than typically seen after natural infections (123,124). Vaccination is recommended regardless of the presence of abnormal cervical cytology, as it may protect against one or more HPV types to which the individual has not been exposed.…”

Section: Prophylactic Vaccinationmentioning

confidence: 99%

“…Clearance of a naturally acquired HPV infection is mediated by a specific cell-mediated immune response in which dendritic cells stimulate T-helper type 1 lymphocytes, which then elicit the production of cytotoxic T lymphocytes that attack infected cells. The ability of an HPV vaccine to stimulate a specific cellular immune response could potentially have a therapeutic effect (124). The current FDA-approved L1 VLP vaccines were designed to prevent HPV infection primarily by stimulating a neutralizing antibody response and were not intended for therapeutic purposes.…”

Section: Therapeutic Vaccinationmentioning

confidence: 99%

Human Papillomavirus

Burd

Dean

2016

Microbiol Spectr

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Individuals with inherited immunodeficiencies, autoimmune disorders, organ or bone marrow transplantation, or infection with human immunodeficiency virus (HIV) are at increased risk of infection with both low-risk and high-risk human papillomavirus (HPV) types. Chronic immunosuppression provides an environment for persistent HPV infection which carries a higher risk of malignant transformation. Screening guidelines have been developed or advocated for processes that have detectable premalignant lesions, such as anal cancer or cervical cancer. For other anatomic locations, such as cutaneous, penile, and oropharyngeal, a biopsy of suspicious lesions is necessary for diagnosis. HPV cannot be cultured from clinical specimens in the laboratory, and diagnosis relies on cytologic, histologic, or molecular methods.

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“…For these reasons, the possible prevention of cervical cancer draws enormous interest. This has seemed to become a reality after the introduction of the HPV vaccine, which induces a cell–mediated immune response preventing HPV infection for many years [ 2 ].…”

mentioning

confidence: 99%