Cell Membrane Camouflaged Hollow Prussian Blue Nanoparticles for Synergistic Photothermal‐/Chemotherapy of Cancer

Abstract

Nanodrug-based cancer therapy has been actively developed in the past decades. The main challenges faced by nanodrugs include poor drug loading capacity, rapid clearance from blood circulation, and low antitumor efficiency with high risk of recurrence. In this work, red blood cell (RBC) membrane camouflaged hollow mesoporous Prussian blue nanoparticles (HMPB@RBC NPs) are fabricated for combination therapy of cancer. The stability, immune evading capacity, and blood retention time of HMPB@RBC NPs are significantly enhanced compared with those of bare HMPB NPs. Doxorubicin (DOX), as a model drug is encapsulated within HMPB@RBC NPs with loading capacity up to 130% in weight. In addition, DOX loaded HMPB@RBC NPs show pH-/photoresponsive release. The in vivo studies demonstrate the outstanding performance of DOX@HMPB@RBC NPs in synergistic photothermal-/chemotherapy of cancer.

Hollow Structures Based on Prussian Blue and Its Analogs for Electrochemical Energy Storage and Conversion

“…Others a) [85] Ni-Fe cube HCl etching Ni-Fe yolk@frame structure Na + /Li + storage [96] Fe-Fe cube Epitaxial growth + HCl etching Fe-Fe shell-in-shell box - [93] Co-Co cube NH 3 etching Co-Co cage [66] Ni-Co cube Ni-Co cage [65] Ni-Fe cube Ni-Fe cage [67] Fe-Fe box Hard template Fe-Fe@Mn-Fe box Others [48] Polystyrene sphere Fe-Fe sphere [80] Mn-Fe cube Co-Fe@Ni-Cr box [79] Mn-Fe cube Cation exchange Co-Fe box Capacitor [86] Co-Fe cube Self-templating epitaxial growth Co-Fe frame and frame-like superstructure - [70] Molecules Spray-drying Cu-Fe superstructure - [105] Hollow PB-and PBA-derived structures Regarding the structural influence on electrochemical performance, different PB-and PBA-based hollow structures have their own merits and demerits. In general, closed single-shelled hollow structures can usually be obtained by more facile routes and applied in a wider range of applications, including LIBs, HSCs, and electrocatalysis.…”

“…[74] Copyright 2010, Royal Society of Chemistry. [81][82][83][84][85] For instance, Hu et al presented a facile route for the preparation of uniform PB hollow particles by using an etching strategy (approach III Figure 1a). [79] Copyright 2013, American Chemical Society.…”

Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

“…[18,19] Sometimes,alarge number of nanoparticles adheres around the blood vessels,w hich causes blood clots. [21][22][23][24][25][26][27][28][29] Recent studies report that cell membranes can be extracted and reconstructed on the surface of nanocarriers for biomedical applications. [21][22][23][24][25][26][27][28][29] Recent studies report that cell membranes can be extracted and reconstructed on the surface of nanocarriers for biomedical applications.…”

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

“…To mount the photothermic efficiency, low energy input, rapid drug release and smaller sizes for biodistribution is demanded. [99] In a recent study, spindle-like polypyrrole hollow nanocapsules were employed for NIR-sensitive DOX Adv. [98] In addition, the hollow structures required less energy for heat stress and thermo-induced deformations, which might offer supersensitive drug release for enhanced drug availability and biosafety.…”