Cell membrane-coated nanoparticles as peroxidase mimetics for cancer cell targeted detection and therapy

Lian, Meiling; Shao, Shuaibin; Liu, Meihan; Shi, Yuqing; Zhang, Haijun; Chen, Da

doi:10.1016/j.talanta.2021.123071

Cited by 17 publications

(7 citation statements)

References 35 publications

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“… Immune cell, stem cell, cancer cell, platelet, RBC Escaping the immune system and long circulation time, cancer targeting, or homologous targeting ability [ 159 – 163 ] Cancer detection Achieving highly specific self-recognition of source cancer cell lines. Cancer cell Display the diversity of antigens on the source cell surface to realize keen detection [ 137 ] Bacterial infection Pore-forming toxins (PFTs) attack or LPS-induced activation of the immune system is the main virulence mechanism. Cell membranes can absorb various PFTs and reduce toxicity.…”

Section: Mechanisms and Functions Of Monotypic Cmc-npsmentioning

confidence: 99%

“…Cell-cell adhesion, cell signaling, cell migration, and gene regulation are significantly influenced by cadherin [134]. Integrins play a role in both cell-cell and cell-extracellular membrane interactions, and they are required for cell proliferation, differentiation, and migration [135][136][137]. Apart from these CCAM proteins, tumor-associated Thomsen-Friedenreich glycoantigen (TF-Ag) with galectin-3 can mediate metastatic cell homotypic aggregation [137].…”

Section: Cancer Cell Membrane-coated Nps (Ccnps)mentioning

confidence: 99%

“…Integrins play a role in both cell-cell and cell-extracellular membrane interactions, and they are required for cell proliferation, differentiation, and migration [135][136][137]. Apart from these CCAM proteins, tumor-associated Thomsen-Friedenreich glycoantigen (TF-Ag) with galectin-3 can mediate metastatic cell homotypic aggregation [137]. Thus, CCNPs use the innate homotypic targeting ability of cancer cell membranes to provide a special cancer targeting technique that may be used for anticancer drug delivery [138].…”

Section: Cancer Cell Membrane-coated Nps (Ccnps)mentioning

confidence: 99%

“…Display the diversity of antigens on the source cell surface to realize keen detection [137] Bacterial infection Pore-forming toxins (PFTs) attack or LPSinduced activation of the immune system is the main virulence mechanism. Cell membranes can absorb various PFTs and reduce toxicity.…”

Section: Cancer Cellmentioning

confidence: 99%

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Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system

Liu

Jiang

et al. 2022

Drug Deliv. and Transl. Res.

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Recently, nanoparticle-based drug delivery systems have been widely used for the treatment, prevention, and detection of diseases. Improving the targeted delivery ability of nanoparticles has emerged as a critical issue that must be addressed as soon as possible. The bionic cell membrane coating technology has become a novel concept for the design of nanoparticles. The diverse biological roles of cell membrane surface proteins endow nanoparticles with several functions, such as immune escape, long circulation time, and targeted delivery; therefore, these proteins are being extensively studied in the fields of drug delivery, detoxification, and cancer treatment. Furthermore, hybrid cell membrane-coated nanoparticles enhance the beneficial effects of monotypic cell membranes, resulting in multifunctional and efficient delivery carriers. This review focuses on the synthesis, development, and application of the cell membrane coating technology and discusses the function and mechanism of monotypic/hybrid cell membrane-modified nanoparticles in detail. Moreover, it summarizes the applications of cell membranes from different sources and discusses the challenges that may be faced during the clinical application of bionic carriers, including their production, mechanism, and quality control. We hope this review will attract more scholars toward bionic cell membrane carriers and provide certain ideas and directions for solving the existing problems. Graphical abstract

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Section: Mechanisms and Functions Of Monotypic Cmc-npsmentioning

confidence: 99%

Section: Cancer Cell Membrane-coated Nps (Ccnps)mentioning

confidence: 99%

Section: Cancer Cell Membrane-coated Nps (Ccnps)mentioning

confidence: 99%

Section: Cancer Cellmentioning

confidence: 99%

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Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system

Liu

Jiang

et al. 2022

Drug Deliv. and Transl. Res.

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“…40 More recently, Zhang et al used cell membrane-coated Au@Pt NPs as a nanoprobe for the colorimetric detection of cancer cells. 41 These colorimetric methods mainly used nanomaterials as a signal-transduction element and involved the synthesis and characterization of nanomaterials. Furthermore, they inevitably required bulky instruments to quantitatively detect cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Portable and sensitive detection of cancer cells via a handheld luminometer

Lei

Shi

Liu

et al. 2022

Analyst

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Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy

Yang,

Zhou,

et al. 2024

Exploration

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Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with relatively low toxicity, they have long been considered for application in repressing cancer progression. Traditional cancer vaccines containing a single or a few discrete tumor epitopes have failed in the clinic, possibly due to challenges in epitope selection, target downregulation, cancer cell heterogeneity, tumor microenvironment immunosuppression, or a lack of vaccine immunogenicity. Whole cancer cell or cancer membrane vaccines, which provide a rich source of antigens, are emerging as viable alternatives. Autologous and allogenic cellular cancer vaccines have been evaluated as clinical treatments. Tumor cell membranes (TCMs) are an intriguing antigen source, as they provide membrane‐accessible targets and, at the same time, serve as integrated carriers of vaccine adjuvants and other therapeutic agents. This review provides a summary of the properties and technologies for TCM cancer vaccines. Characteristics, categories, mechanisms, and preparation methods are discussed, as are the demonstrable additional benefits derived from combining TCM vaccines with chemotherapy, sonodynamic therapy, phototherapy, and oncolytic viruses. Further research in chemistry, biomedicine, cancer immunology, and bioinformatics to address current drawbacks could facilitate the clinical adoption of TCM vaccines.

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Cell membrane-coated nanoparticles as peroxidase mimetics for cancer cell targeted detection and therapy

Cited by 17 publications

References 35 publications

Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system

Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system

Portable and sensitive detection of cancer cells via a handheld luminometer

Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy

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