Cell organelles and yeast longevity: an intertwined regulation

Banerjee, Riddhi; Joshi, Neha; Nagotu, Shirisha

doi:10.1007/s00294-019-01035-0

Cited by 11 publications

(6 citation statements)

References 272 publications

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“… 2013 ; Lin and Austriaco 2014 ; Hibi et al . 2018 ; Banerjee, Joshi and Nagotu 2020 ; Ohtsuka, Shimasaki and Aiba 2021b ). There are several mechanisms of CLS extension by sulfur starvation.…”

Section: Response To Sulfate Starvation In S Pombementioning

confidence: 99%

Response to sulfur in Schizosaccharomyces pombe

Ohtsuka

Shimasaki

Aiba

2021

FEMS Yeast Research

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Sulfur is an essential component of various biologically important molecules, including methionine, cysteine, and glutathione, and it is also involved in coping with oxidative and heavy metal stress. Studies using model organisms, including budding yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe), have contributed not only to understanding various cellular processes but also to understanding the utilization and response mechanisms of each nutrient, including sulfur. Although fission yeast can use sulfate as a sulfur source, its sulfur metabolism pathway is slightly different from that of budding yeast because it does not have a trans-sulfuration pathway. In recent years, it has been found that sulfur starvation causes various cellular responses in S. pombe, including sporulation, cell cycle arrest at G2, chronological lifespan extension, autophagy induction, and reduced translation. This MiniReview identifies two sulfate transporters in S. pombe, Sul1 (encoded by SPBC3H7.02) and Sul2 (encoded by SPAC869.05c), and summarizes the metabolic pathways of sulfur assimilation and cellular response to sulfur starvation. Understanding these responses, including metabolism and adaptation, will contribute to a better understanding of the various stress and nutrient starvation responses and chronological lifespan regulation caused by sulfur starvation.

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Section: Response To Sulfate Starvation In S Pombementioning

confidence: 99%

Response to sulfur in Schizosaccharomyces pombe

Ohtsuka

Shimasaki

Aiba

2021

FEMS Yeast Research

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“…A distinct set of cellular processes is known to define the rate of yeast chronological aging [1,4,[64][65][66][67][68][69][70][71][72]. These processes include coupled mitochondrial respiration [1,4,64,69,[73][74][75][76][77].…”

Section: Each Of the Fifteen Geroprotective Pes Intensifies Mitochondrial Respiration And Alters The Pattern Of Age-related Changes In Inmentioning

confidence: 99%

Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast

et al. 2020

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In a quest for previously unknown geroprotective natural chemicals, we used a robust cell viability assay to search for commercially available plant extracts that can substantially prolong the chronological lifespan of budding yeast. Many of these plant extracts have been used in traditional Chinese and other herbal medicines or the Mediterranean and other customary diets. Our search led to a discovery of fifteen plant extracts that significantly extend the longevity of chronologically aging yeast not limited in calorie supply. We show that each of these longevity-extending plant extracts is a geroprotector that decreases the rate of yeast chronological aging and promotes a hormetic stress response. We also show that each of the fifteen geroprotective plant extracts mimics the longevity-extending, stress-protecting, metabolic and physiological effects of a caloric restriction diet but if added to yeast cultured under non-caloric restriction conditions. We provide evidence that the fifteen geroprotective plant extracts exhibit partially overlapping effects on a distinct set of longevity-defining cellular processes. These effects include a rise in coupled mitochondrial respiration, an altered age-related chronology of changes in reactive oxygen species abundance, protection of cellular macromolecules from oxidative damage, and an age-related increase in the resistance to long-term oxidative and thermal stresses.

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“…[14][15][16][17] The RLS is a model for the aging process of dividing cells (such as stem cells) in higher eukaryotes, whereas CLS is a model for the aging of nondividing cells (such as neurons) in higher eukaryotes. [18] Although these two yeast lifespans share several similarities, differences are present. For example, inhibition of the TOR pathway extends RLS and CLS, although the silent information regulator 2 (Sir2), which is involved in DNA stability, has opposite effects on their lifespans.…”

Section: Introductionmentioning

confidence: 99%

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Ohtsuka,

Shimasaki,

Aiba

2024

Advanced Biology

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Yeast is an excellent model organism for research for regulating aging and lifespan, and the studies have made many contributions to date, including identifying various factors and signaling pathways related to aging and lifespan. More than 20 years have passed since molecular biological perspectives are adopted in this research field, and intracellular factors and signal pathways that control aging and lifespan have evolutionarily conserved from yeast to mammals. Furthermore, these findings have been applied to control the aging and lifespan of various model organisms by adjustment of the nutritional environment, genetic manipulation, and drug treatment using low‐molecular weight compounds. Among these, drug treatment is easier than the other methods, and research into drugs that regulate aging and lifespan is consequently expected to become more active. Chronological lifespan, a definition of yeast lifespan, refers to the survival period of a cell population under nondividing conditions. Herein, low‐molecular weight compounds are summarized that extend the chronological lifespan of Saccharomyces cerevisiae and Schizosaccharomyces pombe, along with their intracellular functions. The low‐molecular weight compounds are also discussed that extend the lifespan of other model organisms. Compounds that have so far only been studied in yeast may soon extend lifespan in other organisms.

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Cell organelles and yeast longevity: an intertwined regulation

Cited by 11 publications

References 272 publications

Response to sulfur in Schizosaccharomyces pombe

Response to sulfur in Schizosaccharomyces pombe

Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

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