Cell penetrating peptide conjugated liposomes as transdermal delivery system of Polygonum aviculare L. extract

Kwon, Soon Sik; Kim, Sun Young; Kong, Bong Ju; Kim, Kyeong Jin; Noh, Geun Young; Im, Na Ri; Lim, Ji Won; Ha, Ji Hoon; Kim, Junoh; Park, Soo Nam

doi:10.1016/j.ijpharm.2015.01.030

Cited by 65 publications

(26 citation statements)

References 31 publications

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“…Also, the incorporation of non-polar compounds probably induces a fluidization effect on lipid vesicles membrane by producing a PC perturbation leading to a deep insertion of polyphenols in phospholipid bilayer, as reported for eugenol and isoeugenol [39]. The results are in agreement with literature data, an increase of particle size being reported because of incorporation of grape-seed [40,41], liquorice [38] and Polygonum aviculare [42] extracts. The size of SE-loaded lipid vesicles increases in order: liposomes < transfersomes < ethosomes.…”

Section: Characterization Of Se Extract−loaded Lipid Vesiclessupporting

confidence: 90%

“…The entrapment efficiency of SE extract in all lipid vesicles was above 75% and increased in order liposomes < transfersomes < ethosomes, the applied preparation methods being efficient. Similar results were reported for the entrapment efficiency of Polygonum aviculare [42], Glycyrrhiza glabra L. [38] and Artemisia arborescens [47]. For liposomes it was obtained the lowest EE because of the cholesterol presence that lowered the incorporation efficiency of polyphenols.…”

Section: Characterization Of Se Extract−loaded Lipid Vesiclessupporting

confidence: 83%

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Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

et al. 2019

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The paper deals with the preparation and characterisation of hydroalcoholic polyphenolic extract from Sambucus ebulus (SE) leaves that was further loaded into three-types of lipid vesicles: liposomes, transfersomes, and ethosomes, to improve its bioavailability and achieve an optimum pharmacological effect. For Sambucus ebulus L.-loaded lipid vesicles, the entrapment efficiency, particle size, polydispersity index and stability were determined. All prepared lipid vesicles showed a good entrapment efficiency, in the range of 75–85%, nanometric size, low polydispersity indexes, and good stability over three months at 4 °C. The in vitro polyphenols released from lipid vehicles demonstrated slower kinetics when compared to the free extract dissolution in phosphate buffer solution at pH 7.4. Either free SE extract or SE extract loaded into lipid vesicles demonstrated a cytoprotective effect, even at low concentration, 5 ug/mL, against hydrogen peroxide-induced toxicity on L-929 mouse fibroblasts’ cell lines. However, the cytoprotective effect depended on the time of the cells pre-treatment with SE extract before exposure to a hydrogen peroxide solution of 50 mM concentration, requiring at least 12 h of pre-treatment with polyphenols with radical scavenging capacity.

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Section: Characterization Of Se Extract−loaded Lipid Vesiclessupporting

confidence: 90%

Section: Characterization Of Se Extract−loaded Lipid Vesiclessupporting

confidence: 83%

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

et al. 2019

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“…In vivo TF test is most frequently used to measure pain levels and assess the effects of anesthesia 42. There were no significant differences in baseline TF latency among all the groups tested.…”

Section: Discussionmentioning

confidence: 94%

A novel local anesthetic system: transcriptional transactivator peptide-decorated nanocarriers for skin delivery of ropivacaine

Chen¹,

You²

2017

DDDT

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PurposeBarrier properties of the skin and physicochemical properties of drugs are the main factors for the delivery of local anesthetic molecules. The present work evaluates the anesthetic efficacy of drug-loaded nanocarrier (NC) systems for the delivery of local anesthetic drug, ropivacaine (RVC).MethodsIn this study, transcriptional transactivator peptide (TAT)-decorated RVC-loaded NCs (TAT-RVC/NCs) were successfully fabricated. Physicochemical properties of NCs were determined in terms of particle size, zeta potential, drug encapsulation efficiency, drug-loading capacity, stability, and in vitro drug release. The skin permeation of NCs was examined using a Franz diffusion cell mounted with depilated mouse skin in vitro, and in vivo anesthetic effect was evaluated in mice.ResultsThe results showed that TAT-RVC/NCs have a mean diameter of 133.2 nm and high drug-loading capacity of 81.7%. From the in vitro skin permeation results, it was observed that transdermal flux of TAT-RVC/NCs was higher than that of RVC-loaded NCs (RVC/NCs) and RVC injection. The evaluation of in vivo anesthetic effect illustrated that TAT-RVC/NCs can enhance the transdermal delivery of RVC by reducing the pain threshold in mice.ConclusionThese results indicate that TAT-decorated NCs systems are useful for overcoming the barrier function of the skin, decreasing the dosage of RVC and enhancing the anesthetic effect. Therefore, TAT-decorated NCs can be used as an effective transdermal delivery system for local anesthesia.

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“…During last decades, there has been a great deal of interest in liposomes as a tool to optimize the topical application of natural substances [49][50][51].…”

Section: Liposomal Vesiclesmentioning

confidence: 99%

Modern drug delivery strategies applied to natural active compounds

Puglia

Lauro

Tirendi

et al. 2016

Expert Opinion on Drug Delivery

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Colloidal drug delivery systems (CDDSs) are innovative carriers that have been studied in pharmaceutical field from many years to overcome unfavorable physical and chemical features of synthetic drugs. Recently the use of CDDS as carriers for phytochemicals has seen an exponential increase which, in some cases, has led to the rediscovery of ancient and forgotten natural molecules. Area covered: This article focuses on the main features of CDDS, particularly micro- and nanoemulsions, vesicular carriers and micro- and nanoparticles, loaded with natural active compounds. A detailed review of the literature is presented, introducing the importance of these systems in terms of their capability to optimize the stability of phytochemicals, their absorption through biological membranes and their bioavailability. Expert opinion: The delivery of phytochemicals is problematic due to poor solubility, poor permeability, low bioavailability, instability in biological milieu and extensive first-pass metabolism. Global research efforts investigating nanotechnology have attempted to overcome these limitations rediscovering and, in some cases, 'discovering ex novo' unexpected virtues and benefits associated to these compounds. The 'nanotechnological approach' can definitely enhance the pharmacokinetics and therapeutic index of natural active compounds and improve their performance in therapy.

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Cell penetrating peptide conjugated liposomes as transdermal delivery system of Polygonum aviculare L. extract

Cited by 65 publications

References 31 publications

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

A novel local anesthetic system: transcriptional transactivator peptide-decorated nanocarriers for skin delivery of ropivacaine

Modern drug delivery strategies applied to natural active compounds

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