Cell reactions and immune responses to photodynamic therapy in oncology

Kubiak, Marcin; Łysenko, Lidia; Gerber, Hanna; Nowak, Rafał

doi:10.5604/17322693.1208196

Cited by 26 publications

(17 citation statements)

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“… 12 , 13 In recent years, some researchers have found that PDT shows efficacy by activating local specific immunity. 14 , 15 Brotosik et al found that PDT resulted in apoptosis of epidermal keratinocytes and Langerhans cells. 16 However, there have been no clinical studies to date on the clinical mechanism of PDT in vitiligo.…”

Section: Discussionmentioning

confidence: 99%

A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

Zhang

Lin

Guo

et al. 2018

An. Bras. Dermatol.

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BackgroundTo study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy.ObjectiveTo assess the clinical efficacy of ALA-PDT for treating vitiligo.MethodsALA with different drug concentrations, drug application durations, irradiation durations and irradiation dosages were adopted to treat skin lesions caused by vitiligo to determine the effective drug concentration, drug application duration, irradiation duration and irradiation dosage for treating three vitiligo volunteers and observe the therapeutic results.ResultsThe clinical trial suggested that ALA at a drug concentration of 1.5%, drug application duration for 3 hours, irradiation dosage of 80mw/cm2 and irradiation duration for 20 min was effective in treating vitiligo. Under these parameters, ALA-PDT was effective to the three vitiligo volunteers, with mild pain and feeling of burning but no other adverse reaction during treatment.Study limitationsDue to the small sample size in this study for the effectiveness of PDT in treating vitiligo and the potential variations in the efficacy for treating the disease at different areas, further studies shall be conducted for confirmation.ConclusionsALA with a drug concentration at 1.5%, drug application duration for 3 hours, irradiation dosage of 80 mw/cm2 and irradiation duration for 20 min is effective in treating vitiligo. Therefore, ALA-PDT is safe and effective in treating the disease, with minor adverse events, providing a new method for treating vitiligo in the future.

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Section: Discussionmentioning

confidence: 99%

A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

Zhang

Lin

Guo

et al. 2018

An. Bras. Dermatol.

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“…As known to all, three main mechanisms by which PDT mediates tumor destruction are now to be defined, namely direct tumor‐cell killing, microvascular collapse, inflammatory and immune responses ( Figure ) . In the first case, PS agents are preferentially taken up and retained by tumor cells, and induce direct cytotoxic effects on tumor cells in close proximity upon irradiation . This could be attributed to irreversible photodamage to important subcellular targets (e.g., plasma membrane, mitochondria) through oxidation of lipids, proteins and amino‐acids by ROS.…”

Section: Antitumor Mechanism Of Nir Light Triggered Pdtmentioning

confidence: 99%

Recent Progress in Near Infrared Light Triggered Photodynamic Therapy

Deng

Huang

et al. 2017

Small

276

179

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Nowadays, photodynamic therapy (PDT) is under the research spotlight as an appealing modality for various malignant tumors. Compared with conventional PDT treatment activated by ultraviolet or visible light, near infrared (NIR) light-triggered PDT possessing deeper penetration to lesion area and lower photodamage to normal tissue holds great potential for in vivo deep-seated tumor. In this review, recent research progress related to the exploration of NIR light responsive PDT nanosystems is summarized. To address current obstacles of PDT treatment and facilitate the effective utilization, several innovative strategies are developed and introduced into PDT nanosystems, including the conjugation with targeted moieties, O self-sufficient PDT, dual photosensitizers (PSs)-loaded PDT nanoplatform, and PDT-involved synergistic therapy. Finally, the potential challenges as well as the prospective for further development are also discussed.

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“…The induced cell death response is dependent on the subcellular localization of PS. A mitochondria-localized PS would likely induce an apoptotic response whereas PS that localized in lysosomes induce a necrotic or apoptotic type of response [35]. In order to enhance their therapeutic efficiency, PSs are constantly being developed and improved by conjugating them with other molecules.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Nano-Mediated Photodynamic Therapy for Cancer: Enhancement of Cancer Specificity and Therapeutic Effects

Tynga

Abrahamse

2018

Preprint

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Deregulation of cell growth and development lead to cancer, a severe condition that claims millions of lives worldwide. Targeted or selective approaches used during cancer treatment determine the efficacy and outcome of the therapy. In order to enhance specificity and targeting and better treatment options for cancer, novel and alternative modalities are currently under development. Photodynamic therapy has the potential to eradicate cancer and combination therapy would yield even greater outcomes. Nanomedicine-aided cancer therapy shows enhanced specificity for cancer cells and minimal side-effects coupled with effective cancer destruction both in vitro and in vivo. Nanocarriers used in drug-delivery systems are well able to penetrate cancer stem cell niche, simultaneously killing cancer cells and eradicate drug-resistant cancer stem cells, yielding therapeutic efficiency up to 100 fold against drug-resistant cancer in comparison with free drugs. Safety precautions should be considered when using Nano-mediated therapy as the effects of extended exposure to biological environments are still to be determined.

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Cell reactions and immune responses to photodynamic therapy in oncology

Cited by 26 publications

References 0 publications

A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo

Recent Progress in Near Infrared Light Triggered Photodynamic Therapy

Nano-Mediated Photodynamic Therapy for Cancer: Enhancement of Cancer Specificity and Therapeutic Effects

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