Nano-Mediated Photodynamic Therapy for Cancer: Enhancement of Cancer Specificity and Therapeutic Effects

Tynga, Ivan Mfouo; Abrahamse, Heidi

doi:10.20944/preprints201810.0271.v1

Cited by 4 publications

(2 citation statements)

References 70 publications

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“…Photodynamic therapy is a traditional and emerging treatment for cancer, focusing only on the cancerous cells without affecting the normal cells. A combination of PDT and nanotechnology-based treatments and diagnosis are novel and effective for cancer [30]. Carbon nanotubes were recently introduced as drug delivery systems due to the large surface area, unique physicochemical characteristics, uptake of cells and easy excretion from the body [31].…”

Section: Discussionmentioning

confidence: 99%

Effective Photodynamic Therapy for Colon Cancer Cells Using Chlorin e6 Coated Hyaluronic Acid-Based Carbon Nanotubes

Prabhavathi

Abrahamse

2020

IJMS

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Colon cancer is the third major cancer contributor to mortality worldwide. Nanosized particles have attracted attention due to their possible contribution towards cancer treatment and diagnosis. Photodynamic therapy (PDT) is a cancer therapeutic modality that involves a light source, a photosensitizer and reactive oxygen species. Carbon nanotubes are fascinating nanocarriers for drug delivery, cancer diagnosis and numerous potential applications due to their unique physicochemical properties. In this study, single walled carbon nanotubes (SWCNTs) were coupled with hyaluronic acid (HA) and chlorin e6 (Ce6) coated on the walls of SWCNTs. The newly synthesized nanobiocomposite was characterized using ultraviolet-visible spectroscopy, Fourier transform electron microscopy (FTIR), X-ray diffraction analysis (XRD), particle size analysis and zeta potential. The loading efficiency of the SWCNTs-HA for Ce6 was calculated. The toxicity of the nanobiocomposite was tested on colon cancer cells using PDT at a fluence of 5 J/cm2 and 10 J/cm2. After 24 h, cellular changes were observed via microscopy, LDH cytotoxicity assay and cell death induction using annexin propidium iodide. The results showed that the newly synthesized nanobiocomposite enhanced the ability of PDT to be a photosensitizer carrier and induced cell death in colon cancer cells.

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Section: Discussionmentioning

confidence: 99%

Effective Photodynamic Therapy for Colon Cancer Cells Using Chlorin e6 Coated Hyaluronic Acid-Based Carbon Nanotubes

Prabhavathi

Abrahamse

2020

IJMS

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“…In the treatment of cancer cells, AgNPs are used as therapeutic agents due to cellular oxidative and apoptotic potential [15,16]. AgNPs offer new uses due to their size-dependent actions and capacity to form various complexes with natural or synthetic molecules [17][18][19].…”

Section: Applications and Importance Of Silver Nanoparticlesmentioning

confidence: 99%

Increasing Trend of Silver Nanoparticles as Antibacterial and Anticancer Agent

Khan¹,

Adnan²,

Begum³

et al. 2023

Self-Assembly of Materials and Their Applications

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Silver nanoparticles (AgNPs) synthesis from plants that already have been reported for medicinal purposes demonstrated better efficacy for curing diseases. Recently, a number of researches have been reported where AgNPs act as promising antibacterial and anticancer agent. Biosynthesized silver nanoparticles (AgNPs) are a type of environmentally friendly, cost-effective, and biocompatible substance that has gotten a lot of attention in treatment of cancer and inhibition of pathogenic microbes. In this chapter, a comprehensive report on the recent development of AgNPs as nanomedicine synthesized from plant extracts. The role and mechanism of AgNPs as antibacterial and anticancer agent was reported that leads towards development of targeted nannomedicines to treat infectious diseases and world most challenging disease like cancer. Reported literature give imminence importance of AgNPs and demonstrated more potency to treat cancer and bacterial infections.

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A Gold Nanoparticle Bioconjugate Delivery System for Active Targeted Photodynamic Therapy of Cancer and Cancer Stem Cells

Didamson

Chandran

Abrahamse

2022

Cancers

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Cancer stem cells (CSCs), also called tumor-initiating cells, are a subpopulation of cancer cells believed to be the leading cause of cancer initiation, growth, metastasis, and recurrence. Presently there are no effective treatments targeted at eliminating CSCs. Hence, an urgent need to develop measures to target CSCs to eliminate potential recurrence and metastasis associated with CSCs. Cancer stem cells have inherent and unique features that differ from other cancer cells, which they leverage to resist conventional therapies. Targeting such features with photodynamic therapy (PDT) could be a promising treatment for drug-resistant cancer stem cells. Photodynamic therapy is a light-mediated non-invasive treatment modality. However, PDT alone is unable to eliminate cancer stem cells effectively, hence the need for a targeted approach. Gold nanoparticle bioconjugates with PDT could be a potential approach for targeted photodynamic therapy of cancer and CSCs. This approach has the potential for enhanced drug delivery, selective and specific attachment to target tumor cells/CSCs, as well as the ability to efficiently generate ROS. This review examines the impact of a smart gold nanoparticle bioconjugate coupled with a photosensitizer (PS) in promoting targeted PDT of cancer and CSC.

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Nano-Mediated Photodynamic Therapy for Cancer: Enhancement of Cancer Specificity and Therapeutic Effects

Cited by 4 publications

References 70 publications

Effective Photodynamic Therapy for Colon Cancer Cells Using Chlorin e6 Coated Hyaluronic Acid-Based Carbon Nanotubes

Effective Photodynamic Therapy for Colon Cancer Cells Using Chlorin e6 Coated Hyaluronic Acid-Based Carbon Nanotubes

Increasing Trend of Silver Nanoparticles as Antibacterial and Anticancer Agent

A Gold Nanoparticle Bioconjugate Delivery System for Active Targeted Photodynamic Therapy of Cancer and Cancer Stem Cells

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