Cell Repellent Coatings on Inner Walls of Tubes by Means of Transporting Discharge in Atmospheric Pressure

Abstract

We report a method to obtain biocompatible PEG copolymer coatings inside High Density Polyethylene (HDPE) and Pyrex tubes, which was successfully developed by using a transporting discharge. The latter being a dry process, it is easier to apply as compared to the conventional multistep wet chemical techniques. The results presented in this paper show that for a 70 cm tube good cell repellent properties as compared to the control was obtained for the entire length of the tube. The best nonfouling properties with respect to CT-26 (colon cancer) were obtained for coatings presenting the best retention of ether functionalities from the DEGME monomer i.e. between 5-25 cm downstream of the tube. These results are interesting for surface modification of biomaterial and biomedical devices which present hollow bodies.

State of the art in nonthermal plasma processing for biomedical applications: Can it help fight viral pandemics like COVID‐19?

“…PEG‐coated high‐density polyethylene and Pyrex tubes, developed via transport discharge in atmospheric plasma, have shown excellent antifouling properties with respect to CT‐26 (colon cancer). [ 72 ] Recently, Stahel et al [73] have demonstrated that atmospheric‐pressure plasma‐polymerized polyoxazoline coatings show remarkable promise as a new class of antibiofouling, biocompatible polymers for biomedical applications. Difficult to synthesize by conventional methods, plasma deposition of 2‐methyl‐2‐oxazoline‐based coatings in nitrogen atmospheric‐pressure DBD has proved to be a successful route toward synthesizing these films.…”