Cell response to mechanical microenvironment cues via Rho signaling: From mechanobiology to mechanomedicine

Mechanochemical coupling of MGF mediates periodontal regeneration

“…Since there is currently no experimental basis for the above relevant parameters. Thus, we adjusted all rate constants to fit our experimental observations, that is, Scleraxis presents a maximum value at 12–24 h and decreases to a normal level at 36–40 h. Similarly, for simplify, molecular number of FAK and MGF proteins are set 1000 and 100, the same order of magnitude as Rho GEF 33 . Actually, the main conclusions drawn from the model were insensitive to the values chosen for rate constants or initial molecular number or rate constant.…”

Substrate viscoelasticity affects human macrophage morphology and phagocytosis

“…This could be due to downregulation of RhoA, Rac1 and/or Cdc42 signaling pathways, which dictate actin dynamics and are responsible for cellular spreading among other cellular processes. 38 Cell morphology is well-established to play a critical role in directing cell function. Hence, to further analyze the effects of vPAA substrates on the macrophage populations, we classified individual cells based on three characteristic morphologies observed (Fig.…”

DNA Nanomachine-Driven Heterogeneous Quadratic Amplification for Sensitive and Programmable miRNA Profiling

“…9,10 Through the orchestration of directed and orderly molecular assembly processes, biological systems can rapidly and accurately respond to external stimuli and subtle shifts in the microenvironment. 11,12 Therefore, heterogeneous reaction systems demonstrate enhanced reactivity at the phase interfaces. By simulating the surface structure of the cell membrane, it is possible to artificially construct a microcatalytic environment that accelerates molecular movement.…”

“…Thus, by emulating the aggregation of high-concentration recognition elements on the surface of the organelle membrane, it is possible to construct a heterogeneous surface within the confinement space, thereby enhancing the reaction efficiency. Indeed, biological processes are not merely an aggregation of uniformly dispersed molecules participating in diffusion-driven reactions. , In the context of the genetic central dogma that governs the flow of genetic information, transcription and translation events occur at heterogeneous interfaces of the organelle, which enhances the efficiency of enzyme-catalyzed reactions by multiple orders of magnitude. , Through the orchestration of directed and orderly molecular assembly processes, biological systems can rapidly and accurately respond to external stimuli and subtle shifts in the microenvironment. , Therefore, heterogeneous reaction systems demonstrate enhanced reactivity at the phase interfaces. By simulating the surface structure of the cell membrane, it is possible to artificially construct a microcatalytic environment that accelerates molecular movement.…”