Cell specific markers for eosinophils and neutrophils in sputum and bronchoalveolar lavage fluid of patients with respiratory conditions and healthy subjects

Metso, T.

doi:10.1136/thorax.57.5.449

Cited by 45 publications

(57 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some of these markers, although, are not entirely specific and may be produced to some extent by some other cells as well (16,17). Among the products of eosinophils ECP (18) and eosinophil peroxidase (EPO) are the most cell-specific (19), as EPX/EDN (eosinophil protein X/eosinophil derived neurotoxin) is also produced in small amounts by neutrophils (20). Myeloperoxidase (MPO) and elastase are also produced in small amounts by monocytes (21)(22)(23).…”

Section: Monitoring Of Inflammationmentioning

confidence: 99%

“…In other body fluids it is not useful as a neutrophil marker, as exocrine glands are major producers of lactoferrin (25). Human neutrophil lipocalin (HNL) on the other hand seems to be an entirely specific marker of neutrophils (19,26,27). When it comes to monocytes/macrophages there is no unique marker available today.…”

Section: Monitoring Of Inflammationmentioning

confidence: 99%

“…(50,51). This in particular has been shown for patients with asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (8,9,19,50,(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69). The greatest problem with sputum measurement is to obtain sputum, as sputum production has to be induced in those subjects who are not spontaneous producers.…”

Section: Various Cellsmentioning

confidence: 99%

See 2 more Smart Citations

Monitoring the allergic inflammation

Venge

2003

Allergy

128

View full text Add to dashboard Cite

Individual symptoms of allergy such as asthma, dermatitis, rhinitis have many different underlying mechanisms. The detailed characterization of the inflammatory mechanisms underlying symptom development in the individual patient is important in order to optimally control treatment. Measurement of eosinophil cationic protein (ECP) in sputum or blood and eosinophil protein X/eosinophil derived neurotoxin (EPX/EDN) in urine may be used to read the involvement of the eosinophil granulocyte in the process. An important information as eosinophil dominated processes seem to be particularly sensitive to corticosteroid treatment. The possibilities to measure the involvement of other inflammatory cells exist today, but are only used to a small extent. The dream would be that every patient with an inflammatory disease is characterized with respect to the profile of involving cells and mediators. Such information would provide us with a unique understanding of the underlying mechanisms of the development of disease symptoms and the possibilities of treating these.

show abstract

Section: Monitoring Of Inflammationmentioning

confidence: 99%

Section: Monitoring Of Inflammationmentioning

confidence: 99%

Section: Various Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Monitoring the allergic inflammation

Venge

2003

Allergy

128

View full text Add to dashboard Cite

show abstract

“…ECP is found in both eosinophils and neutrophils, whereas EPO is said to be a unique component of eosinophils [126]. However, the value of the measurements in COPD is not well understood, especially when their increased levels are not related to an increase in eosinophils and not associated with successful use of prednisolone [64,123].…”

Section: Sputum Inflammatory Markers In Chronic Obstructive Pulmonarymentioning

confidence: 99%

“…However, the value of the measurements in COPD is not well understood, especially when their increased levels are not related to an increase in eosinophils and not associated with successful use of prednisolone [64,123]. That ECP correlates with neutrophils in healthy persons [127] raises the possibility that it may be a product of neutrophils or taken up by them [126].…”

Section: Sputum Inflammatory Markers In Chronic Obstructive Pulmonarymentioning

confidence: 99%

Airway inflammation in COPD: physiological outcome measures and induced sputum

Crapo

Jensen²,

Hargreave³

2003

Eur Respir J

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a result of airway inflammation, and the best predictor of COPD is the early detection of airflow limitation by spirometry. The Global Initiative for Obstructive Lung Disease Workshop Report defines airflow limitation using simple spirometric indices. Available guidelines categorise the severity of COPD using forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), with symptoms playing a minor role in the assessment.Current standards define COPD by progressive loss of FEV1, and thus longitudinal decline in FEV1 will be the primary outcome variable for intervention studies aimed at preventing or reducing the loss of pulmonary function. There is evidence, however, that the variable FEV1/FVC and FEV1 are often not measured properly in all settings.This article will discuss the roles of physiological measurements in diagnosing COPD and physiological outcome measures for COPD. It does not formally compare physiological measures with other outcome measures, such as symptoms or quality of life. Additionally, improved treatment of established disease requires a better understanding of the inflammatory process and its clinical effects and treatment.The inflammatory process, and how drugs affect it, can be studied noninvasively or relatively noninvasively by using refined methods of examining spontaneous or induced sputum. Enhanced understanding of the use of induced sputum will assist in predicting patients9 responses to short-and long-term inhaled corticosteroid treatment, and the methods of sputum examination need to be simplified so that they can be applied more easily to clinical practice. Eur Respir J 2003; 21: Suppl. 41, 19s- Chronic obstructive pulmonary disease (COPD) is defined by the Global Initiative for Obstructive Lung Disease (GOLD) as a "disease state characterised by airflow limitation that is not fully reversible. …The airflow limitation is usually both progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases" [1]. The absence of reversibility tends to exclude asthma by definition, although asthma can coexist with COPD. Methods of assessing airflow limitation: current recommendations and their limitationsAvailable guidelines categorise the severity of COPD primarily by using forced expiratory volume in one second (FEV1), whereas symptoms play a minor role in the assessment [1][2][3][4][5]. This tight link between FEV1 and COPD reflects the fact that spirometry is the standard for defining the presence of airway obstruction and the progressive loss of FEV1, the physiological variable that characterises COPD severity and predicts its mortality. Spirometry has become the standard, in part, because good quality and inexpensive tests are widely available.The GOLD Workshop Report explicitly defines airflow limitation using simple spirometric indices. Specifically, airflow limitation is defined as an FEV1/forced vital capacity (FVC)v70% and a postbronchodilator FEV1v80% of predict...

show abstract

Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps

Lee

Huang

et al. 2020

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background The objective of this work was to assess the efficacy of serum eosinophil cationic protein ECP concentration in predicting early postoperative recurrence in patients with chronic rhinosinusitis with nasal polyps CR-SwNP Methods We prospectively enrolled CRSwNP patients to receive bilateral functional endoscopic sinus surgery FESS and followed them for year Serum ECP level was measured within week before surgery Demographics and associated medical factors were analyzed with the surgical outcome and nasal polyp histology was microscopically examined Results Overall patients met the inclusion criteria and underwent FESS A er at least a-year follow-up period patients had postoperative recurrence with significantly higher serum ECP levels p = Receiver operating characteristic curve analysis showed the optimal cutoff level of serum ECP concentration for predicting the postoperative recurrence of nasal polyps was μg/L p = Regardless of atopy status and histology type logistic regression analysis showed that a higher ECP level was the sole significant factor related to early postopera-tive recurrence of nasal polyps odds ratio p = Cox proportional hazard regression analysis revealed that the hazard ratio of CRSwNP patients with an ECP level of > μg/L resulting in early postoperative recurrence was p = Conclusion Serum ECP appears to be a feasible predictor for early postoperative recurrence of nasal polyps CRSwNP patients with preoperative serum ECP levels of ≥ μg/L had an approximately-fold increased risk of early recurrence CRSwNP patients with higher preoperative serum ECP levels should be closely monitored within the first year a er surgery © 2020 ARS-AAOA, LLC.

show abstract

Cell specific markers for eosinophils and neutrophils in sputum and bronchoalveolar lavage fluid of patients with respiratory conditions and healthy subjects

Cited by 45 publications

References 6 publications

Monitoring the allergic inflammation

Monitoring the allergic inflammation

Airway inflammation in COPD: physiological outcome measures and induced sputum

Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps

Contact Info

Product

Resources

About