Cell to extracellular matrix interactions and their reciprocal nature in cancer

Dijk, Marianne van; Göransson, Sara; Strömblad, Staffan

doi:10.1016/j.yexcr.2013.02.006

Cited by 49 publications

(29 citation statements)

References 63 publications

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“…The idea that the extracellular matrix (ECM) plays a significant role in tumor promotion has gained importance in recent years (Bissell and Hines 2011;LaBarge et al 2009;van Dijk et al 2013). Mast cells produce potent proteases, including chymase, tryptase, collagenases, MMP9, and other gelatinases, and cysteinyl cathepsins.…”

Section: Mast Cells In Prostate Cancermentioning

confidence: 99%

The Role of Inflammation in Prostate Cancer

Sfanos

Hempel

Marzo

2014

Advances in Experimental Medicine and Biology

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In the United States and in "Westernized" countries, the prevalence of both prostate cancer and prostate inflammation is very high, indicating that the two pathologies could be causally related. Indeed, chronic inflammation is now regarded as an "enabling" characteristic of human cancer. Prostate cancer incidence is thought to be mediated in part by genetics, but also by environmental exposures, including the same exposures that may contribute to the development of prostatic inflammation. As our understanding of the role of inflammation in cancer deepens, it is increasingly apparent that "inflammation" as a whole is a complex entity that does not always play a negative role in cancer etiology. In fact, inflammation can play potentially dichotomous (both pro and antitumorigenic) roles depending on the nature and the cellular makeup of the immune response. This chapter will focus on reviewing the current state of knowledge on the role of innate and adaptive immune cells within the prostate tumor microenvironment and their seemingly complex role in prostate cancer in preventing versus promoting initiation and progression of the disease.

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Section: Mast Cells In Prostate Cancermentioning

confidence: 99%

The Role of Inflammation in Prostate Cancer

Sfanos

Hempel

Marzo

2014

Advances in Experimental Medicine and Biology

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“…We next investigated the molecular mechanisms contributing to the enhanced formation of NRVMs with better organization and improved function on AuNP–Col scaffolds, which have not yet been fully identified . Cells can sense and respond to the spatial distribution of ECM ligands and the mechanical properties of the ECM through cell–matrix adhesion complexes, which are signaling platforms composed of integrins bound to ECM proteins such as collagen, laminin, and fibronectin, etc . Recently, we found that mechanical cues from the ECM can affect cell function by influencing the kinetic properties of integrin–ECM protein complexes .…”

mentioning

confidence: 99%

AuNP–Collagen Matrix with Localized Stiffness for Cardiac‐Tissue Engineering: Enhancing the Assembly of Intercalated Discs by β1‐Integrin‐Mediated Signaling

Shi

Tian

et al. 2016

Advanced Materials

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A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c.

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“…However, it is important to effects nanotopological cues on cancer cells, because their ECM affect cancer proliferation, invasion and migration. 21 Since the nanotopological cues are mimetic ECM, 22 in this study, we demonstrated whether silica nanobeads regulate cancer cell adhesion and alteration of morphology, resulting in the silica nanobeads are possible tools of cancer research.…”

Section: Introductionmentioning

confidence: 75%

Alteration of Cell Morphology with Nano- and Micro-Topographical Surface on Closed-Packed Silica Nanobeads

Park

Lee

Park

et al. 2016

j nanosci nanotechnol

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The nanotopological cues are emerging field of in vivo study, because it stimulates alteration of cell morphology and cell behavior such as adhesion, proliferation, differentiation, apoptosis and migration. However, it has not studies nanosurface affected cancer cell behavior, therefore, in this study, we determined that effects the silica nanobeads used as nanotopological tools on cancer cells. For synthesis of silica beads, we made it using stober method and basic amino acid (L-arginine) instead of NH4OH. We carried out rubbing beads to obtain the monolayer silica beads and it used as nanotopological cues for fabrication. It was induced changing cell morphology at 1DIV in group-II (SB-450 and SB-570). However, it was maintained in group-I (SB-118, SB-230) and group-III (SB-1450) like control. Therefore, we separated type-I and type-II surface along with area of cell adhesion and morphology. The characteristic of type-II surface was long distance between contact points, resulting in increase of tension to cells. We found that the morphology rounded up by type-II surface at 1DIV. We described that the nanosurface-induced mechanical tension is associated with alteration of morphology, thus the silica nanobeads used as nanotopological tools for cancer research.

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Cell to extracellular matrix interactions and their reciprocal nature in cancer

Cited by 49 publications

References 63 publications

The Role of Inflammation in Prostate Cancer

The Role of Inflammation in Prostate Cancer

AuNP–Collagen Matrix with Localized Stiffness for Cardiac‐Tissue Engineering: Enhancing the Assembly of Intercalated Discs by β1‐Integrin‐Mediated Signaling

Alteration of Cell Morphology with Nano- and Micro-Topographical Surface on Closed-Packed Silica Nanobeads

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