Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

Christensen, Terje; Kinn, Gunnar; Granli, T.; Amundsen, I.

doi:10.1111/j.1651-2227.1994.tb12943.x

Cited by 33 publications

(25 citation statements)

References 24 publications

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“…22 It was suggested that green light exposure favors the production of lumirubin, while blue light causes more DNA damage and cytotoxicity. 23 However, more recent in vitro studies demonstrated that green fluorescent phototherapy of hyperbilirubinemia may also cause both skin and immune system damage. 19 At present, it remains to be proven whether genotoxic effects observed have clinical implications and if they occur when LED light is used.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

et al. 2003

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OBJECTIVE:To determine the efficacy of blue versus blue-green phototherapy using new light sources with narrow luminous spectra. The devices made of highintensity gallium nitride light-emitting diodes (LEDs) were also compared to conventional halogen-quartz bulbs phototherapy. DESIGN:Prospective open randomized study. PARTICIPANTS:A total of 114 jaundiced, but otherwise healthy term infants who met the entry criteria for phototherapy set by the American Academy of Pediatrics' Practice Parameter. MAIN OUTCOME MEASURES:The duration of phototherapy and the rate of decrease in total serum bilirubin (TSB). RESULTS:The mean TSB concentrations at initiation and termination of treatment, as well as the duration of phototherapy and the rate of decrease in TSB, were not statistically different in newborns receiving blue LED, blue-green LED or conventional phototherapy. The average rate of decrease in TSB (slope), after adjustment by a linear regression analysis for confounding factors, was À3.61 mmol/hour (95% confidence limits À5.47, À1.75) in the 25 newborns receiving blue LED phototherapy compared with À2.57 mmol/hour (À4.32, À0.82) in the 22 newborns treated with bluegreen LED phototherapy and À3.42 mmol/hour (À5.02, À1.81) in the 57 newborns who received conventional phototherapy. CONCLUSIONS:When using low light irradiance, there was no statistically significant difference in the effectiveness of phototherapy using blue-green LEDs, blue LEDs or conventional halogen-quartz bulbs.

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Section: Discussionmentioning

confidence: 99%

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

et al. 2003

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“…Thus, with respect to effectiveness, the turquoise light had no advantage over the blue light. However, potential side effects may be less serious in phototherapy with longer wavelengths: in cell cultures containing bilirubin, turquoise light caused less DNA damage (12) and was less cytotoxic (13), compared with blue light. Furthermore, during phototherapy with blue light, the serum level of riboflavin decreased due to photodecomposition (14).…”

Section: Discussionmentioning

confidence: 99%

Effect of phototherapy with turquoise vs. blue LED light of equal irradiance in jaundiced neonates

et al. 2015

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“…It has been thought for a long time that phototherapy and bilirubin, as a factor of increasing light sensitivity, might have harmful effects on DNA and some previous studies showed these effects. Christensen et al (14) and Wu et al (15) showed increased cytotoxicity and DNA damage in newborn lymphocytes that were exposed to blue light especially. Similar to our study, Karadag et al (16) reported that both enhanced and conventional phototherapy increased the frequency of SCE.…”

Section: Discussionmentioning

confidence: 99%

The effect of phototherapy on sister chromatid exchange with different light density in newborn hyperbilirubinemia

Kanmaz¹,

Okur²,

Díllí³

et al. 2018

Turk Pediatri Ars

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Aim: Concerns of possible genotoxic effects of hyperbilirubinemia and phototherapy were raised from experimental and observational studies in neonates. The purpose of this study was to assess the effect of hyperbilirubinemia and phototherapy with three different methods on DNA damage by investigating sister chromatid exchange frequency. Material and Methods: Patients whose gestational ages were >37 weeks and bilirubin levels above phototherapy limits were enrolled into three groups and each group was planned to receive 25 babies. Group 1 received enhanced light-emitting diode phototherapy, group 2 had light-emitting diode phototherapy, and group 3 received conventional phototherapy. Infants with hyperbilirubinemia but did not require phototherapy comprised the control group, which was subdivided into two groups regarding bilirubin levels (10mg/dL). Blood samples were collected before and after phototherapy for sister chromatid exchange frequency and samples were examined by a biologist who was blinded to the study groups. Results: The mean pre-treatment sister chromatid exchange frequency was 1.41±0.34/cell, post-treatment 2.65±0.68/cell, and 1.61±0.61/ cell for the control group (p<0.05). A statistically significant increase in sister chromatid exchange frequency after phototherapy was observed in all three intervention groups (p values: 0.01, 0.01, and 0.008, respectively). When the treatment groups were compared with each other in terms of irradiance, no significant difference was found (p=0.08). Conclusions: Phototherapy causes an increase in the frequency of sister chromatid exchange regardless of the irradiance. Phototherapy could have some genotoxic adverse effects on chromosomes; however, further investigations are warranted to enlighten as to whether these effects are permanent or clinically important.

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Cells, bilirubin and light: formation of bilirubin photoproducts and cellular damage at defined wavelengths

Cited by 33 publications

References 24 publications

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

Effect of phototherapy with turquoise vs. blue LED light of equal irradiance in jaundiced neonates

The effect of phototherapy on sister chromatid exchange with different light density in newborn hyperbilirubinemia

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