Effect of phototherapy with turquoise vs. blue LED light of equal irradiance in jaundiced neonates

Ebbesen, Finn; Vandborg, Pernille Kure; Madsen, Poul Thøis; Trydal, Torleif; Jakobsen, Lasse; Vreman, Hendrik J.

doi:10.1038/pr.2015.209

Cited by 25 publications

(17 citation statements)

References 23 publications

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“…In our subsequent clinical investigation, also with equal irradiance on the infants, we then compared the effects of light emitted from narrow-band light emitting diodes (LEDs) centered at 497 nm (turquoise) and 459 nm (blue), respectively. The same decrease in the TSB concentration was observed in both groups of late preterm and term infants (11). An extension of this randomized, controlled, nonblinded clinical study was done to compare the levels of bilirubin isomers in the infant's serum, the results of which we report below.…”

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confidence: 79%

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Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs. 459 nm (blue)

et al. 2016

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confidence: 79%

“…The study groups and treatments have been described in detail previously (11). Briefly, infants were enrolled in the study at the neonatal intensive care unit at Aalborg University Hospital, Denmark between 1 January 2013 and 31 December 2013.…”

Section: Study Groupsmentioning

confidence: 99%

Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs. 459 nm (blue)

et al. 2016

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“…With provision that most receivers of phototherapy are the jaundiced newborn infants, the irradiation time should be strictly controlled, thus making the phototherapy time-consuming and agonizing. Even the blue light source of light- emitting diode (LED), which is regarded as a low-intensity light source, cannot eliminate the side effects such as hyperthermia, insensible water loss and rash4.…”

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confidence: 99%

Efficient Photocatalytic Bilirubin Removal over the Biocompatible Core/Shell P25/g-C3N4 Heterojunctions with Metal-free Exposed Surfaces under Moderate Green Light Irradiation

Kang

Qin

Zhang

et al. 2017

Sci Rep

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Highly-monodispersed g-C3N4/TiO2 hybrids with a core/shell structure were synthesized from a simple room temperature impregnation method, in which g-C3N4 was coated through self-assembly on the commercially available Degussa P25 TiO2 nanoparticles. Structural and surface characterizations showed that the presence of g-C3N4 notably affected the light absorption characteristics of TiO2. The g-C3N4/TiO2 heterojunctions with metal-free exposed surfaces were directly used as biocompatible photocatalysts for simulated jaundice phototherapy under low-power green-light irradiation. The photocatalytic activity and stability of g-C3N4/TiO2 were enhanced relative to pure P25 or g-C3N4, which could be ascribed to the effective Z-scheme separation of photo-induced charge carriers in g-C3N4/TiO2 heterojunction. The photoactivity was maximized in the 4 wt.% g-C3N4-coated P25, as the bilirubin removal rate under green light irradiation was more than 5-fold higher than that under the clinically-used blue light without any photocatalyst. This study approves the future applications of the photocatalyst-assisted bilirubin removal in jaundice treatment under moderate green light which is more tolerable by humans.

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“…A study conducted using serum samples from jaundiced newborn infants, found that a significant decrease in the bilirubin values at 6 h after samples were exposed to white fluorescent light (Leung et al, 1992). Another in-vivo study conducted using jaundiced infants indicated that LED light and turquoise light had similar effect in reducing bilirubin after 24 h exposure period (Ebbesen et al, 2016).…”

Section: Effect Of Artificial Light After Keeping For 24 Hmentioning

confidence: 97%

How Do Light and Temperature Affect Laboratory Investigations on Serum Bilirubin?

Damayanthi¹,

Bandara²,

Priyadarshani³

2018

J. res. health sci.

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Abstract:Bilirubin is important in disease diagnosis and it is considered as a photosensitive molecule. Therefore, precautions are important while analyzing samples to be measured bilirubin in the laboratory to avoid under-estimations. Hence, this study was designed to investigate the effect of temperature, sun-light and artificial light on the stability of serum bilirubin. Whole blood was collected from 34 apparently healthy subjects and serum was separated. To determine the effect of temperature serum was exposed to -4°C and 33°C for 2h and 24h. To investigate the effect of light the serum specimens were exposed to sun-light for 6h and two CFL bulbs, 15W each for 24h. Bilirubin concentrations were measured by dimethylsulfoxide method using automated Mindray BF 300 analyzer. The differences between base-line bilirubin value and other subsequent measurements were analyzed by post-hoc Dunnets test. There were significant reduction in all the bilirubin fractions in the samples exposed to sun-light for 6h and only total and indirect bilirubin fractions significantly had been reduced in the samples exposed to artificial light. The same effect was observed in the normobilirubinaemic samples exposed to 33°C for 24h but in hyperbilirubinaemic samples all the bilirubin fractions had been reduce significantly. There was no significant reduction of bilirubin in samples stored at -4°C for 2h and 24h and at 33°C for 2h. Therefore, serum samples to be measured bilirubin can be stored at -4°C up to 24h and 33°C up to 2h with light protection, without significant changes in bilirubin concentrations.

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Effect of phototherapy with turquoise vs. blue LED light of equal irradiance in jaundiced neonates

Cited by 25 publications

References 23 publications

Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs. 459 nm (blue)

Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs. 459 nm (blue)

Efficient Photocatalytic Bilirubin Removal over the Biocompatible Core/Shell P25/g-C3N4 Heterojunctions with Metal-free Exposed Surfaces under Moderate Green Light Irradiation

How Do Light and Temperature Affect Laboratory Investigations on Serum Bilirubin?

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