Cells, cytokines, chemokines, and cancer stress: A biobehavioral study of patients with chronic lymphocytic leukemia

Andersen, Barbara L.; Goyal, Neha; Weiss, David M.; Westbrook, Travis D.; Maddocks, Kami J.; Byrd, John C.; Johnson, Amy J.

doi:10.1002/cncr.31538

Cited by 26 publications

(27 citation statements)

References 79 publications

(141 reference statements)

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“…IL-6 is a cytokine with a wide variety of functions and its expression is typically elevated as part of the immune response (19). The production of IL-6 is stimulated by foreign bodies, including bacteria, endotoxin and dust particles (20).…”

Section: Discussionmentioning

confidence: 99%

Decreased expression of microRNA‑30b promotes the development of pulpitis by upregulating the expression of interleukin‑6 receptor

Zhang

Yang

et al. 2019

Exp Ther Med

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Section: Discussionmentioning

confidence: 99%

Decreased expression of microRNA‑30b promotes the development of pulpitis by upregulating the expression of interleukin‑6 receptor

Zhang

Yang

et al. 2019

Exp Ther Med

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“…Aberrant secretion of cytokines to tumor site is one of the features of CAFs. It is acknowledged that cytokines serve as mediators in shaping tumor microenvironment and facilitating tumor progression . Previous studies have reported that C‐X‐C motif chemokine ligand 12 (CXCL12), interferon‐γ (IFN‐γ), CXCL9/10/11 and IL6 promoted PD‐L1 expression in cancer cells .…”

Section: Introductionmentioning

confidence: 99%

“…It is acknowledged that cytokines serve as mediators in shaping tumor microenvironment and facilitating tumor progression. 9,10 Previous studies have reported that C-X-C motif chemokine ligand 12 (CXCL12), interferon-γ (IFN-γ), CXCL9/10/11 and IL6 promoted PD-L1 expression in cancer cells. [11][12][13][14] In this regard, we postulated that CAFs-derived cytokines might promote PD-L1 expression.…”

Section: Introductionmentioning

confidence: 99%

Cancer‐associated fibroblasts promote PD‐L1 expression in mice cancer cells via secreting CXCL5

Zhou

Zhang

et al. 2019

Intl Journal of Cancer

153

131

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Cancer‐associated fibroblasts (CAFs) play a key role in orchestrating the tumor malignant biological properties within tumor microenvironment and evidences demonstrate that CAFs are a critical regulator of tumoral immunosuppression of the T cell response. However, the functions and regulation of CAFs in the expression of programmed death‐ligand 1 (PD‐L1) in melanoma and colorectal carcinoma (CRC) are not completely understood. Herein, by scrutinizing the expression of α‐SMA and PD‐L1 in melanoma and CRC tissues, we found that CAFs was positive correlated with PD‐L1 expression. Further analyses showed that CAFs promoted PD‐L1 expression in mice tumor cells. By detecting a majority of cytokines expression in normal mice fibroblasts and CAFs, we determined that CXCL5 was abnormal high expression in CAFs and the immunohistochemistry and in situ hybridization confirmed that were CAFs which were expressing CXCL5. In addition, CXCL5 promoted PD‐L1 expression in B16, CT26, A375 and HCT116. The silencing of CXCR2, the receptor of CXCL5, inhibited the PD‐L1 expression induced by CAFs in turn. Functionally, CXCL5 derived by CAFs promoted PD‐L1 expression in mice tumor cells through activating PI3K/AKT signaling. LY294002, the inhibitor of PI3K, confirmed that CXCL5 forested an immunosuppression microenvironment by promoting PD‐L1 expression via PI3K/AKT signaling. Meanwhile, the B16/CT26 xenograft tumor models were used and both CXCR2 and p‐AKT were found to be positively correlated with PD‐L1 in the xenograft tumor tissues. The immunosuppressive action of CAFs on tumor cells is probably reflective of them being a potential therapeutic biomarker for melanoma and CRC.

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“…Kini et al in their study reflected the link between pathological angiogenesis and tumor clone in CLL, which revealed a significant rise in the density of microvessels in bone marrow biopsies of the patients, suffering from CLL, compared with control sections [45]. In addition, interleukins 10 and 6, produced by B-lymphocytes in excess of the norm, participate in the angiogenesis stimulation in CLL [46,47]. Meta-analysis demonstrated that interleukin-10 expression predicted the worst progression-free survival in patients with hematological malignancies [48].…”

Section: Relationship Between Pathological Angiogenesis and Vegf Levelmentioning

confidence: 98%

Endothelial dysfunction in patients with lymphoproliferative disorders and its changes in the course of polychemotherapy

et al. 2020

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The article is dedicated to contemporary views on the change of endothelial function in the patients with lymphoproliferative disorders prior to, and in the process of, chemotherapeutic treatment. Considering that possibilities of standard examination do not always help identifying subclinical endothelial dysfunction, it is necessary to use specific methods, in particular, to determine the levels of endothelin-1 and vascular endothelial growth factor to monitor endothelial function. The objective of this review is to identify problems and prospects for recognizing early subclinical changes of endothelial function in the patients with lymphoproliferative disorders before and after chemotherapy. Assessing presence and severity of endothelial dysfunction may be useful for determining subclinical stages of cardiovascular damage, stratifying the risk of the patients with confirmed cardiovascular disease, and reducing the likelihood of cardio- and endotheliotoxic effects in patients long after chemotherapy. That is why early detection and immediate therapy of cardiovascular toxicity is currently the most important task in the patients with lymphoproliferative disorders, receiving chemotherapy.

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Cells, cytokines, chemokines, and cancer stress: A biobehavioral study of patients with chronic lymphocytic leukemia

Cited by 26 publications

References 79 publications

Decreased expression of microRNA‑30b promotes the development of pulpitis by upregulating the expression of interleukin‑6 receptor

Decreased expression of microRNA‑30b promotes the development of pulpitis by upregulating the expression of interleukin‑6 receptor

Cancer‐associated fibroblasts promote PD‐L1 expression in mice cancer cells via secreting CXCL5

Endothelial dysfunction in patients with lymphoproliferative disorders and its changes in the course of polychemotherapy

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