Cells Involved in the Immune Response

Richter, M.; Rose, B.; Abdou, Nabih I.

doi:10.1159/000230280

Cited by 29 publications

(1 citation statement)

References 19 publications

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“…'-3 The antigen-reactive cell has been localized to the bone marrow. 4 By subjecting normal rabbits to varying doses of irradiation, coupled with cell transfer experiments, we have previously demonstrated that a dependent relationship exists between the capacity of the rabbit to synthesize humoral antibody and the presence of functionally active antigen-reactive cells in the bone marrow. 5 Evidence has also been presented strongly suggesting that these cells vacate the bone marrow after contact with the antigen, leaving behind antigen-reactive cells capable of transferring immunocompetence to a recipient 800 r irradiated rabbit with respect to all antigens except the one used to immunize the cell donor."…”

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confidence: 99%

Cells Involved in Cell-Mediated and Transplantation Immunity in the Rabbit, I. The Noninvolvement of the Bone Marrow Antigen Reactive Cell in the Transplant Rejection Reaction

Richter

Abdou

Midgley

1970

Proc. Natl. Acad. Sci. U.S.A.

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Abstract. Rabbits were subjected to 800 r total body irradiation to render them immunoincompetent with respect to the humoral immune response. These rabbits were, however, only slightly less capable of rejecting skin allografts than nonirradiated rabbits. Furthermore, the administration of normal or specifically "primed" bone marrow cells (bone marrow obtained from a rabbit injected one to two days previously with the spleen cells obtained from the prospective skin donor) did not enhance or inhibit the graft rejection reaction. It is concluded that the cells mediating the humoral immune response are different from those mediating the cellular immune response.Introduction. Previous investigations from this laboratory have established that at least two cell-types are required for the mediation of the humoral immune response in the rabbit, the antigen-reactive cell and the antibody-forming cell.'-3 The antigen-reactive cell has been localized to the bone marrow.4 By subjecting normal rabbits to varying doses of irradiation, coupled with cell transfer experiments, we have previously demonstrated that a dependent relationship exists between the capacity of the rabbit to synthesize humoral antibody and the presence of functionally active antigen-reactive cells in the bone marrow.5 Evidence has also been presented strongly suggesting that these cells vacate the bone marrow after contact with the antigen, leaving behind antigen-reactive cells capable of transferring immunocompetence to a recipient 800 r irradiated rabbit with respect to all antigens except the one used to immunize the cell donor." 2 Since the bone marrow can be depleted of antigen-reactive cells precommitted to interact with an antigen as complex as the lymphocyte,7 it was proposed to utilize the cell transfer system to determine the role of antigenreactive cells in transplant rejection reactions. As will be seen below, the bone marrow antigen-reactive cell does not play a role in the mediation of this reaction.

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confidence: 99%

Cells Involved in Cell-Mediated and Transplantation Immunity in the Rabbit, I. The Noninvolvement of the Bone Marrow Antigen Reactive Cell in the Transplant Rejection Reaction

Richter

Abdou

Midgley

1970

Proc. Natl. Acad. Sci. U.S.A.

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Adverse Effects of Topical Antiglaucoma Medication

Broadway¹

1994

Arch Ophthalmol

307

194

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Cells of the Immune System

Todd

2010

Encyclopedia of Life Sciences

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The immune system includes a range of cell types with different roles in defending the body against infection. Many of these cells arise in the bone marrow, circulate in the blood and can migrate into solid tissues. Immune responses involve interactions between some of these cells and/or their secreted products. B and T lymphocytes specifically react to microbial antigens: activated B lymphocytes secrete antigen‐binding antibodies, and subpopulations of T lymphocytes possess regulatory or cytotoxic functions. Natural killer cells are also cytotoxic cells of the lymphoid lineage, but they do not possess properties of antigen recognition. Different types of dendritic cells present antigens to T and B lymphocytes. Blood monocytes give rise to tissue macrophages that are phagocytes, as are circulating neutrophils, which are the most plentiful type of granulocyte. Other circulating granulocytes are eosinophils that secrete toxic mediators, and basophils that, in common with tissue mast cells, are important sources of inflammatory mediators. Other cells contribute to immune and inflammatory responses, including endothelial cells, erythrocytes and platelets. Key Concepts: A variety of cell types are important components of the immune system. B and T lymphocytes specifically recognise antigens and are responsible for adaptive (acquired) immunity. B lymphocytes recognise native (unprocessed) antigens via surface immunoglobulins and produce secreted immunoglobulins (antibodies). T lymphocytes recognise processed antigens (usually peptides) associated with MHC proteins expressed on the surface of antigen‐presenting cells. Different T lymphocyte subpopulations have helper, cytotoxic or regulatory functions. Natural killer (NK) cells are lymphoid cells that lack antigen‐specific receptors, but mediate cytotoxic activity against infected or malignant cells. Dendritic cells are potent antigen‐presenting cells involved in the activation of T lymphocytes, whereas follicular dendritic cells present antibody‐associated antigens to B lymphocytes. Monocytes are circulating blood cells that give rise to tissue macrophages with phagocytic and antigen presentation functions. Granulocytes circulate in the blood, migrate into tissues, and include phagocytic neutrophils and eosinophils that secrete toxic mediators, and basophils that release inflammatory mediators; mast cells are tissue cells with similar properties to basophils. A variety of other cell types contribute to the generation and regulation of immune and inflammatory responses, including endothelial cells, erythrocytes and platelets.

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Cells Involved in the Immune Response

Cited by 29 publications

References 19 publications

Cells Involved in Cell-Mediated and Transplantation Immunity in the Rabbit, I. The Noninvolvement of the Bone Marrow Antigen Reactive Cell in the Transplant Rejection Reaction

Cells Involved in Cell-Mediated and Transplantation Immunity in the Rabbit, I. The Noninvolvement of the Bone Marrow Antigen Reactive Cell in the Transplant Rejection Reaction

Adverse Effects of Topical Antiglaucoma Medication

Cells of the Immune System

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