Cells-on-chip based transducer platform for probing toxicity of metal nanoparticles

Niazi, Javed H.; Pandey, Ashish; Gürbüz, Yaşar; Ozguz, V.; Qureshi, Anjum

doi:10.1016/j.snb.2016.03.105

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Figure 5a shows the sensor impedance decreases as the frequency increases, indicating how AC frequency affect the impedance, which is simlar to impedance measurements for bacteira detection and nano particle tocixity study in literature. 37,38 As we mesure the current gain at time doamin by giving a single pulse, the current singal is sampled at 2 ms, shown in supplementary S1 (available online at stacks.iop.org/JSS/9/055020/mmedia). At 2 ms, the current get steady and thus current signal taken here can be considerably regarded as in low requency region.…”

Section: Resultsmentioning

confidence: 99%

Highly Sensitive Lead Ion Detection in One Drop of Human Whole Blood Using Impedance-Modulated Field-Effect Transistors and a Portable Measurement Device

Wang

Hsieh

Sukesan

et al. 2020

ECS J. Solid State Sci. Technol.

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This study reports the development of a rapid heavy metal ion screening tool for whole blood samples. The test system consists of an ion selective membrane-based impedance modulated field effect transistor (FET) sensor and a portable sensor measurement unit. This study focuses on the direct detection of lead ions in whole blood, without extensive sample pre-treatments. The sensing methodology is based on impedance changes in the membrane due to the specific ionophore-target metal ion interaction in the presence of a strong electric field. The changes in impedance caused by heavy metal ions are amplified by the FET to obtain a highly sensitive lead ion detection, with very low detection limit (near 10−11 ∼ 10−10 M Pb2+). To reduce the complexity and enhance sensor performance, the whole blood samples are fractionated on chip without any external actuation/automation using simple gravitational blood cell separation. The test results in PBS, human serum and whole blood samples demonstrate high sensitivity and wide dynamic range of lead ion detection. The miniaturized extended gate FET sensor system is ideal for point of care and home-care diagnostics for heavy metal ion in blood.

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Section: Resultsmentioning

confidence: 99%

Highly Sensitive Lead Ion Detection in One Drop of Human Whole Blood Using Impedance-Modulated Field-Effect Transistors and a Portable Measurement Device

Wang

Hsieh

Sukesan

et al. 2020

ECS J. Solid State Sci. Technol.

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Recent advances in microfluidic 3D cellular scaffolds for drug assays

Chen

Liu

et al. 2017

TrAC Trends in Analytical Chemistry

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Evaluating nanomedicine with microfluidics

Ranganathan

2018

Nanotechnology

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Nanomedicines are engineered nanoscale structures that have an extensive range of application in the diagnosis and therapy of many diseases. Despite the rapid progress in and tremendous potential of nanomedicines, their clinical translational process is still slow, owing to the difficulty in understanding, evaluating, and predicting their behavior in complex living organisms. Microfluidic techniques offer a promising way to resolve these challenges. Carefully designed microfluidic chips enable in vivo microenvironment simulation and high-throughput analysis, thus providing robust platforms for nanomedicine evaluation. Here, we summarize the recent developments and achievements in microfluidic methods for nanomedicine evaluation, categorized into four sections based on their target systems: single cell, multicellular system, organ, and organism levels. Finally, we provide our perspectives on the challenges and future directions of microfluidics-based nanomedicine evaluation.

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Cells-on-chip based transducer platform for probing toxicity of metal nanoparticles

Cited by 3 publications

References 29 publications

Highly Sensitive Lead Ion Detection in One Drop of Human Whole Blood Using Impedance-Modulated Field-Effect Transistors and a Portable Measurement Device

Highly Sensitive Lead Ion Detection in One Drop of Human Whole Blood Using Impedance-Modulated Field-Effect Transistors and a Portable Measurement Device

Recent advances in microfluidic 3D cellular scaffolds for drug assays

Evaluating nanomedicine with microfluidics

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